Epidemiology of Staphylococcus aureus in Italy: First nationwide survey, 2012

Campanile, Floriana; Bongiorno, Dafne; Perez, Marianna; Mongelli, Gino; Sessa, Laura; Benvenuto, Sabrina; Gona, Floriana; Varaldo, Pietro E.; Stefani, Stefania

doi:10.1016/j.jgar.2015.06.006

Cited by 47 publications

(34 citation statements)

References 23 publications

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“…The results also mimicked the findings of a surveillance study conducted in 2005 in Kuwait hospitals [23] and two studies conducted in the USA and Canada [20,24] where skin and soft tissues were the major sources of MRSA isolates. In contrast to the findings of this study, lower respiratory tract samples were the major sources accounting for 40.6% of MRSA isolates obtained during an Italian national survey conducted in 2012 [25] . These findings highlight the geographical differences in the epidemiology of MRSA colonization and/or infection.…”

Section: Discussioncontrasting

confidence: 99%

“…The observation that all MRSA isolates were susceptible to linezolid is similar to reports from other countries that MRSA isolates were susceptible to linezolid [20,22,25] . In addition, the MIC distribution of the glycopeptide antibiotics showed that the majority ( ∼ 97%) of the isolates were susceptible to vancomycin and teicoplanin (MIC: ≤ 2 μg/ml), confirming that vancomycin and teicoplanin remain viable options for treating MRSA infections in Kuwait.…”

Section: Discussionsupporting

confidence: 87%

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Antibiotic Resistance Trends in Methicillin-Resistant Staphylococcus aureus Isolated in Kuwait Hospitals: 2011-2015

Udo

Boswihi²

2017

Med Princ Pract

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Objective: The aim of this study was to determine antibiotic resistance trends and carriage of staphylococcal cassette chromosome mec (SCCmec) genetic elements in methicillin-resistant Staphylococcus aureus (MRSA) isolated in Kuwait hospitals to ascertain whether they were healthcare associated (HA-MRSA) or community associated (CA-MRSA). Materials and Methods: In total, 6,922 MRSA isolates obtained from different clinical samples were tested for resistance toantibiotics, urease production, and carriage of SCCmec elements. Results: All MRSA isolates were susceptible to linezolid, vancomycin, and teicoplanin. However, some isolates were resistant to kanamycin (2,979; 43%), ciprofloxacin (2,955; 42.7%), erythromycin and clindamycin (2,935; 42.4%), fusidic acid (2,858; 41.2%), gentamicin (2,665; 38.5%), tetracycline (2,652; 38.3%), and trimethoprim (2,324; 33.5%). Whereas the prevalence of resistance to most antibiotics showed annual variations, those resistant to chloramphenicol and rifampicin increased from 2.6 and 0.1% to 9.6 and 1.6%, respectively, and high-level mupirocin resistance declined from 9.3% in 2011 to 3.6% in 2015. In total, 3,244 (53.9%) of the isolates carried SCCmec IV followed by SCCmec III (1,737; 28.8%) and SCCmec V (890; 14.8%). SCCmec I (21; 0.3%) and II (79; 0.8%) occurred sporadically. A total of 3,651 (60.7%) of the isolates belonged to the CA-MRSA genotype and 2,290 isolates (38.1%) were identified as HA-MRSA. Conclusion: This study demonstrates changes in antibiotic resistance patterns of MRSA over time and reinforces the value of surveillance in detecting such changes for the benefit of infection control and patient management.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 87%

Antibiotic Resistance Trends in Methicillin-Resistant Staphylococcus aureus Isolated in Kuwait Hospitals: 2011-2015

Udo

Boswihi²

2017

Med Princ Pract

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“…Rates of MRSA fluctuated between 34% and 41% between 2012 and 2014 and these results are comparable with those previously published by Stefani et al [7]. Similarly, an Italian study by Campanile et al in 2012 identified 35.8% of S. aureus isolates as MRSA [4]. The EARS-Net report shows that Italy was one of seven European countries to have percentages of MRSA >25%.…”

Section: Discussionsupporting

confidence: 86%

“…Following this, rates of methicillin-resistant Staphylococcus aureus (MRSA) have stabilized in some areas and have decreased in others [1]. Italy is no exception to this, with reports of decreasing rates of MRSA over recent years [4]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of the Activity of Tigecycline against Gram-Positive and Gram-Negative Organisms Collected from Italy between 2012 and 2014, as Part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.)

Stefani

Dowzicky

2016

Pharmaceuticals

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As part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T) we report the in vitro activity of tigecycline and its comparators against Gram-negative and Gram-positive organisms collected from Italian centers between 2012 and 2014. Minimum inhibitory concentrations were determined according to the broth microdilution methodology of the Clinical and Laboratory Standards Institute, and antimicrobial resistance was determined using the European Committee on Antimicrobial Susceptibility Testing interpretive criteria. Among the Enterobacteriaceae, 31% of Escherichia coli isolates, 22% of Klebsiella pneumoniae, and 1% of Klebsiella oxytoca were extended-spectrum β-lactamase producers (ESBLs). Resistance rates among ESBL-K. pneumoniae and ESBL-E. coli to meropenem were 24% and <1%, respectively. Thirty-seven percent of K. pneumoniae were multidrug resistant (MDR) strains. Resistance rates among isolates of Acinetobacter baumannii to amikacin, levofloxacin and meropenem were between 84% and 94%. Eighty percent of A. baumannii isolates were MDR strains. Methicillin-resistant Staphylococcus aureus (MRSA) accounted for 38% of S. aureus isolates. No isolates of MRSA were resistant to linezolid, tigecycline or vancomycin. Antimicrobial resistance remains a problem in Italy with increasing numbers of MDR organisms. Despite high levels, MRSA rates appear to be stabilising. Tigecycline retains its in vitro activity against the majority of organisms, including those with multidrug resistance.

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“…It is prone to raising multiple drug resistance. As found in 3-month epidemiological study to determine the prevalence and antibiotic resistance of S. aureus nosocomial infections in 52 centers throughout Italy in 2012, the prevalence of S. aureus among all nosocomial pathogens isolated in that period was 11.6% ( n = 2541), whilst the prevalence of methicillin-resistant S. aureus (MRSA) among the S. aureus was 35.8% ( n = 910) [38]. However, the collection S. aureus strain ATCC 25923 exhibited a high susceptibility to Cefazolin in vitro and was chosen as a model object for in vivo studies of efficiency of K. pinnata extracts which was compared with this antibiotic.…”

Section: Resultsmentioning

confidence: 99%

Bactericide, Immunomodulating, and Wound Healing Properties of TransgenicKalanchoe pinnataSynergize with Antimicrobial Peptide Cecropin P1 In Vivo

Лебедева

Захарченко

Трубникова

et al. 2017

Journal of Immunology Research

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Procedure of manufacturing K. pinnata water extracts containing cecropin P1 (CecP1) from the formerly described transgenic plants is established. It included incubation of leaves at +4°C for 7 days, mechanical homogenization of leaves using water as extraction solvent, and heating at +70°C for inactivating plant enzymes. Yield of CecP1 (after heating and sterilizing filtration) was 0.3% of total protein in the extract. The water extract of K. pinnata + CecP1 exhibits favorable effect on healing of wounds infected with S. aureus (equal to Cefazolin) and with a combination of S. aureus with P. aeruginosa (better than Cefazolin). Wild-type K. pinnata extract exhibited evident microbicide activity against S. aureus with P. aeruginosa but it was substantially strengthened in K. pinnata + CecP1 extract. K. pinnata extracts (both wild-type and transgenic) did not exhibit general toxicity and accelerated wound recovery. Due to immunomodulating activity, wild-type K. pinnata extract accelerated granulation of the wound bed and marginal epithelialization even better than K. pinnata + CecP1 extract. Immunomodulating and microbicide activity of K. pinnata synergizes with microbicide activity of CecP1 accelerating elimination of bacteria.

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Epidemiology of Staphylococcus aureus in Italy: First nationwide survey, 2012

Cited by 47 publications

References 23 publications

Antibiotic Resistance Trends in Methicillin-Resistant Staphylococcus aureus Isolated in Kuwait Hospitals: 2011-2015

Antibiotic Resistance Trends in Methicillin-Resistant Staphylococcus aureus Isolated in Kuwait Hospitals: 2011-2015

Assessment of the Activity of Tigecycline against Gram-Positive and Gram-Negative Organisms Collected from Italy between 2012 and 2014, as Part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.)

Bactericide, Immunomodulating, and Wound Healing Properties of TransgenicKalanchoe pinnataSynergize with Antimicrobial Peptide Cecropin P1 In Vivo

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