Most research on the pandemic today assumes that this situation is stressful and requires coping. The aim was to study subjective well-being in the situation of the pandemic and its relationship to coping and anxiety about coronavirus. 409 people filled Satisfaction With Life Scale, Scale of Positive And Negative Experiences, situational version of COPE, checklists assessing anxiety of infection and anxiety of the negative consequences of the pandemic. The comparison groups were three samples of 98, 66 and 293 people who filled Satisfaction With Life Scale and Scale of Positive And Negative Experiences in 2017 and 2019. There was a lower level of positive emotions among respondents in a situation of self-isolation, but the same level of satisfaction with life and negative emotions. Anxiety about the pandemic is related to higher negative emotions only. Emotionally oriented coping strategies and mental disengagement are associated with a higher level of pandemic anxiety. Problem-oriented and active coping strategies are weakly associated with lower anxiety that could be explained by the lack of ready effective methods of resolving this new and uncertain situation. Anxiety associated with current, acute and imminent risk (such as risk of infection), concentration on emotions and acceptance may not be dysfunctional strategies, as they are not associated with deterioration in overall well-being. On the contrary, attempts to cope with anxiety regarding negative consequences of a pandemic by mental disengagement, substance use and denial are associated with a lower level of satisfaction with life.
Pathways of Personality Development: Following Lev Vygotsky's Guidelines the other. Being very enthusiastic about Marxism, as the methodological foundation for the new post-crisis psychology, Vygotsky shared Marx's idea that the human essence lies in social relations, "brought inside and transformed into personality functions, representing the dynamic parts of its structure" [Vygotsky 1984a: 224]. The concept of higher psychological functions, introduced by Vygotsky, expressed this idea in the most articulate form. It was as
Previously transgenic Kalanchoe pinnata plants producing an antimicrobial peptide cecropin P1 (CecP1) have been reported. Now we report biological testing K. pinnata extracts containing CecP1 as a candidate drug for treatment of wounds infected with Candida albicans. The drug constitutes the whole juice from K. pinnata leaves (not ethanol extract) sterilized with nanofiltration. A microbicide activity of CecP1 against an animal fungal pathogen in vivo was demonstrated for the first time. However, a favorable therapeutic effect of the transgenic K. pinnata extract was attributed to a synergism between the fungicide activity of CecP1 and wound healing (antiscar), revascularizing, and immunomodulating effect of natural biologically active components of K. pinnata. A commercial fungicide preparation clotrimazole eliminated C. albicans cells within infected wounds in rats with efficiency comparable to CecP1-enriched K. pinnata extract. But in contrast to K. pinnata extract, clotrimazole did not exhibit neither wound healing activity nor remodeling of the scar matrix. Taken together, our results allow assumption that CecP1-enriched K. pinnata extracts should be considered as a candidate drug for treatment of dermatomycoses, wounds infected with fungi, and bedsores.
The article presents an analytical review of literature on publication metrics as a tool of performance management in academia. Issues of quantitative research assessment are investigated in the light of modern views of motivation, in particular through the lens of self-determination theory (SDT). The article provides an insight into empirical studies on the effects of intrinsic and extrinsic motivation on publication productivity, research quality and subjective wellbeing. Accumulated international experience in performance management is used as a basis for developing recommendations on how to improve academic governance.
Procedure of manufacturing K. pinnata water extracts containing cecropin P1 (CecP1) from the formerly described transgenic plants is established. It included incubation of leaves at +4°C for 7 days, mechanical homogenization of leaves using water as extraction solvent, and heating at +70°C for inactivating plant enzymes. Yield of CecP1 (after heating and sterilizing filtration) was 0.3% of total protein in the extract. The water extract of K. pinnata + CecP1 exhibits favorable effect on healing of wounds infected with S. aureus (equal to Cefazolin) and with a combination of S. aureus with P. aeruginosa (better than Cefazolin). Wild-type K. pinnata extract exhibited evident microbicide activity against S. aureus with P. aeruginosa but it was substantially strengthened in K. pinnata + CecP1 extract. K. pinnata extracts (both wild-type and transgenic) did not exhibit general toxicity and accelerated wound recovery. Due to immunomodulating activity, wild-type K. pinnata extract accelerated granulation of the wound bed and marginal epithelialization even better than K. pinnata + CecP1 extract. Immunomodulating and microbicide activity of K. pinnata synergizes with microbicide activity of CecP1 accelerating elimination of bacteria.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.