Epidemiology of Spotted Fever Group and Typhus Group Rickettsial Infection in the Amazon Basin of Peru

Forshey, Brett M.; Stewart, Allison J.; Morrison, Amy C.; Gálvez, Hugo; Rocha, Claudio; Astete, Helvio; Eza, Dominique; Chen, Hua Wei; Chao, Chien Chung; Bentzel, David E; Ching, Wei Mei; Kochel, Tadeusz J.

doi:10.4269/ajtmh.2010.09-0355

Cited by 37 publications

(44 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Evidence of the spotted fever group (SFG) rickettsial infections have been documented from diverse areas of Peru (Schoeler et al 2005, Forshey et al 2010, including a 2002 outbreak in Sapillica, Piura, Peru. Serological evidence from villagers during that outbreak showed that the prevalence of immunoglobulin M (IgM) antibody to SFG rickettsiae ranged from 10% to 19% among the human population (Blair et al 2004a).…”

Section: Introductionmentioning

confidence: 99%

Detection ofRickettsia parkerifrom within Piura, Peru, and the First Reported Presence ofCandidatusRickettsia andeanae in the TickRhipicephalus sanguineus

Flores-Mendoza

Florin

Felices

et al. 2013

Vector-Borne and Zoonotic Diseases

View full text Add to dashboard Cite

Domestic farm animals (n = 145) were sampled for the presence of ectoparasites in northwestern Peru during March, 2008. Ninety domestic animals (62%) were positive for the presence of an ectoparasite(s) and produced a total collection of the following: 728 ticks [Amblyomma maculatum, Anocentor nitens, Rhipicephalus (Boophilus) microplus, Rhipicephalus sanguineus, and Otobius megnini], 12 lice (Haematopinus suis), and 3 fleas (Ctenocephalides felis). A Rickettsia genus-specific qPCR assay was performed on nucleic acid preparations of the collected ectoparasites that resulted in 5% (37/743, 35 ticks and 2 fleas) of the ectoparasites positive for the presence of Rickettsia. DNA from the positive individual ticks was tested with 2 other qPCR assays for the presence of the ompB gene in Candidatus Rickettsia andeanae or Rickettsia parkeri. Candidatus R. andeanae was found in 25 A. maculatum ticks and in two Rh. sanguineus ticks, whereas R. parkeri was detected in 6 A. maculatum ticks. Two A. maculatum were co-infected with both Candidatus R. andeanae and R. parkeri. Rickettsia felis was detected in 2 fleas, Ctenocephalides felis, by multilocus sequence typing of the 17-kD antigen and ompA genes. These findings expand the geographic range of R. parkeri to include Peru as well as expand the natural arthropod vector of Candidatus R. andeanae to include Rhipicephalus sanguineus.

show abstract

Section: Introductionmentioning

confidence: 99%

Detection ofRickettsia parkerifrom within Piura, Peru, and the First Reported Presence ofCandidatusRickettsia andeanae in the TickRhipicephalus sanguineus

Flores-Mendoza

Florin

Felices

et al. 2013

Vector-Borne and Zoonotic Diseases

View full text Add to dashboard Cite

show abstract

“…On the other hand, higher seroprevalence values have been reported from other countries. A seroprevalence of 10.3% for the typhus group was reported from the Peruvian Amazon Basin (Forshey et al 2010). A study in Spain showed a seroprevalence against R. typhi and R. felis of 3.8-18% and 3.2-6.5%, respectively (Bernabeu-Wittel et al 2006, Nogueras et al 2006, Bolañ os-Rivero et al 2011.…”

mentioning

confidence: 96%

Flea-Borne Rickettsioses in the North of Caldas Province, Colombia

Hidalgo

Montoya

Martínez

et al. 2013

Vector-Borne and Zoonotic Diseases

View full text Add to dashboard Cite

Rickettsia typhi and R. felis are the etiological agents of murine typhus and flea-borne spotted fever, respectively. Both are emerging acute febrile zoonotic diseases for which fleas are vectors; they also have similar clinical characteristics and global distribution. In 2005, we identified the circulation of murine typhus in 6 towns within the mountainous coffee-growing area north of Caldas, Colombia. We now report the specific seroprevalence against R. typhi and R. felis, and associated risk factors in 7 towns of this province. The combined seroprevalence against the 2 flea-borne rickettsioses is the highest yet reported in the literature: 71.7% (17.8% for R. felis, 25.2% for R. typhi, and 28.7% for both). We also report a prospective analysis of 26 patients with a febrile illness compatible with rickettsioses, including murine typhus; 9 of these patients had a rickettsiosis. This supports our sero-epidemiological results and highlights the diagnostic complexity of febrile syndromes in this region.

show abstract

“…17 In addition, the 17kD sequences obtained in this study were identical with Rickettsia sp. RF2125, which was detected in fleas obtained from the United States, 18 Peru, 19 and Uruguay. 20 Although existing data suggest a worldwide distribution of Rickettsia sp.…”

mentioning

confidence: 99%

Molecular Detection of Rickettsia felis, Bartonella henselae, and B. clarridgeiae in Fleas from Domestic Dogs and Cats in Malaysia

Mokhtar¹,

Tay²

2011

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

The presence of Rickettsia felis, Bartonella henselae and B. clarridgeiae in 209 fleas (Ctenocephalides felis) obtained from domestic cats and dogs in several locations in Malaysia was investigated in this study. Using a polymerase chain reaction specific for the citrate synthase (gltA) and 17-kD antigenic protein (17kD) genes of rickettsiae, we detected R. felis DNA in 6 (2.9%) fleas. For detection of bartonellae, amplification of the heme-binding protein (pap31) and riboflavin synthase (ribC) genes identified B. henselae and B. clarridgeiae DNA in 24 (11.5%) and 40 (19.1%) fleas, respectively. The DNA of B. henselae and B. clarridgeiae was detected in 10 (4.8%) fleas. Two B. henselae genogroups (Marseille and Houston-1) were detected in this study; genogroup Marseille (genotype Fizz) was found more often in the fleas. The findings in this study suggest fleas as potential vectors of rickettsioses and cat-scratch disease in this country.

show abstract

Epidemiology of Spotted Fever Group and Typhus Group Rickettsial Infection in the Amazon Basin of Peru

Cited by 37 publications

References 38 publications

Detection ofRickettsia parkerifrom within Piura, Peru, and the First Reported Presence ofCandidatusRickettsia andeanae in the TickRhipicephalus sanguineus

Detection ofRickettsia parkerifrom within Piura, Peru, and the First Reported Presence ofCandidatusRickettsia andeanae in the TickRhipicephalus sanguineus

Flea-Borne Rickettsioses in the North of Caldas Province, Colombia

Molecular Detection of Rickettsia felis, Bartonella henselae, and B. clarridgeiae in Fleas from Domestic Dogs and Cats in Malaysia

Contact Info

Product

Resources

About