Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting

Abstract

BackgroundUp-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality trends for hospitalized patients with sepsis in a European setting, while avoiding selection bias in relation to different complexity hospitals.MethodsA large retrospective analysis of a 5-year period (2008–2012) was conducted of hospital discharge records obtained from the Catalan Health System (CatSalut) Minimum Basic Data Set for Acute-Care Hospitals (a mandatory population-based register of admissions to all public and private acute-care hospitals in Catalonia). Patients hospitalized with sepsis were detected on the basis of ICD-9-CM codes used to identify acute organ dysfunction and infectious processes.ResultsOf 4,761,726 discharges from all acute-care hospitals in Catalonia, 82,300 cases (1.72%) had sepsis diagnoses. Annual incidence was 212.7 per 100,000 inhabitants/year, rising from 167.2 in 2008 to 261.8 in 2012. Length of hospital stay fell from 18.4 to 15.3 days (p < .00001), representing a relative reduction of 17%. Hospital mortality fell from 23.7 to 19.7% (p < .0001), representing a relative reduction of 16.9%. These differences were confirmed in the multivariate analysis (adjusted for age group, sex, comorbidities, ICU admission, emergency admission, organ dysfunction, number of organ failures, sepsis source and bacteraemia).ConclusionsSepsis incidence has risen in recent years, whereas mortality has fallen. Our findings confirm reports for other parts of the world, in the context of scarce administrative data on sepsis in Europe.Electronic supplementary materialThe online version of this article (doi:10.1186/s13613-017-0241-1) contains supplementary material, which is available to authorized users.

Lipidomic profile and candidate biomarkers in septic patients

“…A large observational study in a European setting revealed an estimated mean sepsis incidence of 212.7 cases per 100,000 inhabitants with an annual incidence increase of 7.3%. In Brazil, sepsis incidence was 36.3 per 1000 patient-days and sepsis mortality was 55.7% [12].…”

Prolonged length of stay in the emergency department and increased risk of hospital mortality in patients with sepsis requiring ICU admission

“…A substantial number of patients with sepsis require intensive care unit (ICU) admission for close monitoring and supportive therapy 1. Close monitoring of conditions such as unstable vitals and circulatory haemodynamics, oxygen supply and demand, and respiratory dysfunction are key components in the successful treatment of severe sepsis and septic shock.…”

Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device

“…Fast spreading bacterial infections induce acute infections, critical illnesses as meningitis, as well as life-threatening conditions as sepsis. 1,2 In particular, sepsis with a mortality rate of 30% [3][4][5][6][7] requires fast and accurate diagnosis as the survival chances decreases by 7-8% for every hour that the infection remains untreated. [8][9][10] Rapid, sensitive and quantifiable bacterial detection from patient blood is thus a clinical demand.…”