Epidemiology of rotavirus infection among young children with acute diarrhoea in Burkina Faso

Bonkoungou, Isidore Juste O.; Sanou, Idrissa; Bon, Fabienne; Benon, Benoit; Coulibaly, Sheick Oumar; Haukka, Kaisa; Traoré, Alfred S.; Barro, Nicolas

doi:10.1186/1471-2431-10-94

Cited by 46 publications

(63 citation statements)

References 22 publications

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“…The present work is a continuation of a previous study on rotavirus epidemiology in Burkina Faso [Bonkoungou et al, 2010], which revealed that rotavirus accounted for 33.8% of diarrheal episodes. Genotyping of human rotavirus strains revealed a great diversity of G and P genotypes circulating in urban Burkina Faso.…”

Section: Discussionmentioning

confidence: 51%

“…Rotavirus occurs mostly during the period from December to March, corresponding to the dry season and relatively cool and cold nights, as has been reported in Burkina Faso and elsewhere in West Africa Rodrigues et al, 2007;Akran et al, 2010;Bonkoungou et al, 2010]. During the study period, rotavirus strains varied from one season to another: the most common strains G2P [6] and G9P [8] were identified during the first rotavirus season and G1P[8] during both rotavirus seasons (Fig.…”

Section: Discussionmentioning

confidence: 86%

“…The present work is a continuation of a previous study on rotavirus epidemiology in Burkina Faso, in which group A rotavirus prevalence was found to be 33.8% [Bonkoungou et al, 2010]. The objective of this study was to determine the diversity of G and P genotypes of the rotavirus strains circulating among children with acute diarrhea in Burkina Faso during two consecutive rotavirus seasons from 2008 to 2010.…”

Section: Introductionmentioning

confidence: 85%

“…Rotavirus positive samples used for the present study were those in which group A rotavirus was detected in a previous study, for which full details of the sampling and testing procedures as well as clinical and sociodemographic information of the children are published [Bonkoungou et al, 2010]. Briefly, 447 children under the age of 5 years, who had diarrhea and/or were admitted to the Centre Médical avec Antenne Chirugicale ( …”

Section: Rotavirus Positive Samplesmentioning

confidence: 99%

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Genotype diversity of group A rotavirus strains in children with acute diarrhea in urban Burkina Faso, 2008–2010

Bonkoungou¹,

Damanka²,

Sanou³

et al. 2011

Journal of Medical Virology

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In this study, the diversity of G and P genotypes of rotavirus strains in Burkinabe children were examined. Between November 2008 and February 2010, 447 stool samples were collected from children <5 years of age with acute diarrhea visiting hospital in Ouagadougou. Group A rotavirus was previously detected in 151/447 (33.8%) of the samples tested by an immunochromatographic test and these samples were now tested further for rotavirus G and P genotypes by RT‐PCR. Of these, the rotavirus type genes were amplified by RT‐PCR for 140/151 (92.7%) samples and G and P genotypes were successfully determined for 81 (57.9%) and 130 (92.9%) samples, respectively. The most prevalent G genotypes were G1, 34/140 (24.3%), and G9, 21/140 (15%), while the predominant P genotypes were P[6], 56/140 (40%), and P[8], 54/140 (38.6%). Among the single infections, 63/140 (45%), the predominant G/P combinations were: G1P[8] (33%), G9P[8] (29%), and G2P[6] (14%). The unusual strains G1P[9] (3%), G12P[6] (3%), G10P[6] (2%), and G2P[8] (2%) were also detected. In a high number of strains 61/140 (43.6%), the G genotype could not be determined and mixed infections were determined in 17/140 (12.1%) of strains identified. This study highlights the high diversity and presence of unusual rotavirus strains in children in Burkina Faso. J. Med. Virol. 83:1485–1490, 2011. © 2011 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 85%

Section: Rotavirus Positive Samplesmentioning

confidence: 99%

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Genotype diversity of group A rotavirus strains in children with acute diarrhea in urban Burkina Faso, 2008–2010

Bonkoungou¹,

Damanka²,

Sanou³

et al. 2011

Journal of Medical Virology

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“…Here we report on a viral metagenomic analysis of feces of children from Burkina Faso with acute diarrhea (12) allowing the characterization of their enteric viruses, including the genetic characterization of novel parvoviruses from a previously unrecognized genus (12,13).…”

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confidence: 99%

Acute Diarrhea in West African Children: Diverse Enteric Viruses and a Novel Parvovirus Genus

Phan

Bonkoungou

et al. 2012

J Virol

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139

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g Parvoviruses cause a variety of mild to severe symptoms or asymptomatic infections in humans and animals. During a viral metagenomic analysis of feces from children with acute diarrhea in Burkina Faso, we identified in decreasing prevalence nucleic acids from anelloviruses, dependoviruses, sapoviruses, enteroviruses, bocaviruses, noroviruses, adenoviruses, parechoviruses, rotaviruses, cosavirus, astroviruses, and hepatitis B virus. Sequences from a highly divergent parvovirus, provisionally called bufavirus, were also detected whose NS1 and VP1 proteins showed <39% and <31% identities to those of previously known parvoviruses. Four percent of the fecal samples were PCR positive for this new parvovirus, including a related bufavirus species showing only 72% identity in VP1. The high degree of genetic divergence of these related genomes from those of other parvoviruses indicates the presence of a proposed new Parvoviridae genus containing at least two species. Studies of the tropism and pathogenicity of these novel parvoviruses will be facilitated by the availability of their genome sequences.

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Molecular epidemiology of rotavirus and norovirus in Ile‐Ife, Nigeria: High prevalence of G12P[8] rotavirus strains and detection of a rare norovirus genotype

Japhet

Adesina

Famurewa

et al. 2012

Journal of Medical Virology

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Rotavirus (RV) and norovirus (NoV) are considered the most common causes of viral gastroenteritis in children. In this study, the prevalence of RV and NoV infection in 55 children with diarrhea from the rural community Akinlalu in Southwestern Nigeria was investigated using real‐time PCR assays. The RV and NoV strains were genotyped by PCR and/or sequencing. RV and NoV infections occurred with a prevalence of 34.5% and 25.5% respectively, with predominance in children <1 year. Most infections occurred during the dry season with increasing prevalence of RV as the dry season progressed (October–January). Infections with RV VP6 subgroup (SG) II were more prevalent (27.3%) than SGI (7.3%). Similarly, NoV genogroup II infections were more common (23.6%) than genogroup I (1.8%). Five children out of 55 (9.1%) were co‐infected with both RV and NoV. Notably, G12P[8] was the predominant RV strain (36.8%, n = 7), observed for the first time in Nigeria. The VP7 gene of the G12 strains clustered within lineage III, sharing high nucleotide identity with each other (>99%) indicating introduction in Nigeria from a single donor. Furthermore, a putative novel genotype within genogroup I NoV was detected, which till date has only been reported once in humans. To conclude, a high prevalence of the emerging G12P[8] RV strain was observed for the first time in Nigeria, as well as a putative novel NoV genotype in humans. These results provide new information which can be important for future vaccine evaluations and possible introduction in Nigeria. J. Med. Virol. 84:1489–1496, 2012. © 2012 Wiley Periodicals, Inc.

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Epidemiology of rotavirus infection among young children with acute diarrhoea in Burkina Faso

Cited by 46 publications

References 22 publications

Genotype diversity of group A rotavirus strains in children with acute diarrhea in urban Burkina Faso, 2008–2010

Genotype diversity of group A rotavirus strains in children with acute diarrhea in urban Burkina Faso, 2008–2010

Acute Diarrhea in West African Children: Diverse Enteric Viruses and a Novel Parvovirus Genus

Molecular epidemiology of rotavirus and norovirus in Ile‐Ife, Nigeria: High prevalence of G12P[8] rotavirus strains and detection of a rare norovirus genotype

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