Epidemiology of recurrent seizure disorders and epilepsy in cats under primary veterinary care in the United Kingdom

O'Neill, D G; Phillipps, Stephanie; Egan, Jordon; Brodbelt, David; Church, David; Volk, Holger A.

doi:10.1111/jvim.15881

Cited by 18 publications

(25 citation statements)

References 51 publications

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“…First, dogs referred for further investigation of epileptic seizures may have more refractory disease proving more difficult to control in the primary care setting; secondly, the time and expertise available for the management of chronic conditions such as epilepsy in referral practice does not reflect that in general practice. Studies that have utilised health records from primary-care veterinary practices have mainly evaluated the prevalence and risk factors of epileptic seizures in both dogs and cats (Erlen et al 2018, O'Neill et al 2020. Less emphasis has been placed on the clinical approach to epileptic seizures by primary care clinicians.…”

Section: Introductionmentioning

confidence: 99%

Approach to initial management of canine generalised epileptic seizures in primary‐care veterinary practices in the United Kingdom

Green

Lowrie

Singleton

et al. 2022

J of Small Animal Practice

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To investigate how primary care clinicians in the UK approach initial management of canine generalised epileptic seizures, including factors potentially associated with prescription and choice of anti-seizure drugs.Materials and MethOds: Electronic health records concerning 3,150,713 consultations (917,373 dogs) were collected from 224 veterinary practices by the Small Animal Veterinary Surveillance Network.Free-text clinical narratives were reviewed to identify those consistent with generalised epileptic seizure activity, including only those recording the first presentation for seizures. Dogs older than 6 years

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Section: Introductionmentioning

confidence: 99%

Approach to initial management of canine generalised epileptic seizures in primary‐care veterinary practices in the United Kingdom

Green

Lowrie

Singleton

et al. 2022

J of Small Animal Practice

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“…[20][21][22][23][24]26,27 A 2020 study by O'Neill et al found that 0.15% of BSH cats and 0.16% of the total number of cats presenting to primary veterinary care over 1 year showed recurrent epileptic seizures and no convincing evidence for a high prevalence of recurrent epileptic seizures in any cat breed, but the small number of purebred cats with epilepsy might have influenced their results. 25 Although not an aim of this study, pedigree data available through SVERAK confirmed that two cats in the PIE group were closely related; both had generalised epileptic seizures. Further studies, including pedigree data with a larger number of affected cases, are needed to evaluate genetic epilepsy in cats.…”

Section: Discussionmentioning

confidence: 59%

Epilepsy in British Shorthair cats in Sweden

Tenger¹,

Meervenne

Varjonen³

et al. 2021

Journal of Feline Medicine and Surgery

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Objectives The primary objective of this study was to investigate the prevalence of epileptic seizures and of presumed idiopathic epilepsy (PIE, describing epilepsy of unknown origin) in a cohort of British Shorthair (BSH) cats in Sweden. The secondary objective was to describe epileptic seizure characteristics and outcome for cats with PIE. Methods Owners of BSH cats born between 2006 and 2016 and registered with SVERAK (the Swedish Cat Clubs’ National Association) were invited to reply to a questionnaire about their cat’s general health. Owners who indicated that their cat had experienced epileptic seizures were invited to participate in an in-depth telephone interview about the epileptic seizures. The clinical characteristics of epileptic seizures in BSH cats were determined from the results of the interview. Results In this population comprising 1645 BSH cats (representing 28% of registered BSHs), the prevalence of epileptic seizures was 0.9% and for PIE it was 0.7%. BSH cats with PIE presented with infrequent but consistent epileptic seizures. Twenty-seven percent of BSH cats with epileptic seizures had cluster seizures but none presented with status epilepticus. None of the BSH cats was treated with antiepileptic drugs, and none of the owners reported epileptic seizure remission in their cat. Conclusions and relevance The prevalence of PIE in this population of BSH cats was 0.7%. The prevalence of epileptic seizures was 0.9%. In general, PIE in the BSH cat displayed a relatively benign phenotype where progression of epileptic seizures was uncommon.

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“…Given the large area of forebrain affected in this case, it seems surprising that the clinical response to anti‐seizure medication was so positive. Observation of feline seizures by owners may be poor compared to that of dogs 40,41 ; however, this is less likely to be a significant feature in this case as the cat was indoor only. The good response in this case supports the possible benefits of pursuing treatment despite severe imaging changes in similar patients.…”

Section: Discussionmentioning

confidence: 79%

Late‐onset seizures in a domestic shorthaired cat with global brain ischaemia and cortical laminar necrosis

Phillipps

Schiborra

Nagendran

2022

Vet Record Case Reports

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The most common cause of global brain ischaemia in veterinary species is anaesthesiarelated cardiovascular dysfunction. Both early-and late-onset seizures secondary to ischaemia are well recognised in human medicine, but late-onset seizures have not been reported in veterinary species. A 2-year-old, female, neutered, domestic shorthaired cat with a history of blindness since ovariohysterectomy 10 months previously was presented for investigation of suspected seizure activity over the previous month. Neurological examination localised to generalised diffuse forebrain pathology. Magnetic resonance imaging was consistent with global brain ischaemia and suggestive of cortical laminar necrosis. The clinical history and imaging findings were consistent with historical perioperative cerebral hypoxia. Treatment with phenobarbitone resulted in excellent control of seizures. Anaesthesia accidents can occur during short, 'routine' procedures in apparently clinically healthy animals and may have severe long-term effects for patients. This report suggests that late-onset seizures can occur as a result of global brain ischaemia in veterinary species.

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Epidemiology of recurrent seizure disorders and epilepsy in cats under primary veterinary care in the United Kingdom

Cited by 18 publications

References 51 publications

Approach to initial management of canine generalised epileptic seizures in primary‐care veterinary practices in the United Kingdom

Approach to initial management of canine generalised epileptic seizures in primary‐care veterinary practices in the United Kingdom

Epilepsy in British Shorthair cats in Sweden

Late‐onset seizures in a domestic shorthaired cat with global brain ischaemia and cortical laminar necrosis

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