Epidemiology of primary hyperparathyroidism in Tayside, Scotland, UK

Yu, Ning; Donnan, Peter T.; Murphy, Michael J.; Leese, Graham

doi:10.1111/j.1365-2265.2008.03520.x

Cited by 175 publications

(133 citation statements)

References 22 publications

(77 reference statements)

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“…ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ, 6,2016 Таким образом, проект клинических рекомен-даций обсуждался среди специалистов профессор-ско-преподавательского состава, организаторов здравоохранения в области эндокринологии и прак-тических врачей, занимающихся проблемами ги-перпаратиреоза.…”

Section: описание метода валидизации рекомендацийunclassified

“…Соотношение мужчин и жен-щин -1:3. Ежегодная заболеваемость варьирует от 0,4-18,8 случаев на 10 000 человек в зависимости от качества диспансерного обслуживания [6][7][8][9][10][11][12].…”

Section: клинические рекомендацииunclassified

“…**-в некоторых семьях с FIHP были обнаружены мутации в генах MEN1, CASR или CDC73/HRPT2. ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ, 6,2016 жеперечисленных признаков (уровень доказатель-ности 2, класс рекомендаций В):…”

Section: другие про-явленияunclassified

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Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment

Dedov

Иванович²,

Мельниченко

et al. 2017

Probl Endokrinol (Mosk)

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Primary hyperparathyroidism (PHT) is the third most common endocrine disorder in men and women after diabetes mellitus and thyroid disease and one of the most frequent causes of osteoporosis and fractures among the secondary osteopathy. PHT refers to socially significant problems in connection with involvement in the pathological process of the majority of organs and system In recent years, the conception of epidemiology, clinic and tactics of management of patients with PHT has changed due to significant increase of morbidity at the expense of identification of mild forms of disease. The modern management concept tactics depends on clinical manifestations. Bearing in mind the importance of the problem under consideration, the working group was set up for the development of federal recommendations on the treatment of PHT based on the principles of evidence-based medicine. The experience accumulated by the domestic and international experts was summarized in the federal clinical guidelines on PHT.

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Section: описание метода валидизации рекомендацийunclassified

Section: клинические рекомендацииunclassified

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Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment

Dedov

Иванович²,

Мельниченко

et al. 2017

Probl Endokrinol (Mosk)

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“…Primary hyperparathyroidism (PHPT) is a common disease with a population prevalence traditionally estimated to be 0.1-0.4% (1,2,3), previously estimated to be 0.1-0.4% (2,4) and recently up to 0.7% (5,6). The diagnostic incidence has increased considerably after the introduction of multichannel biochemistry.…”

Section: Introductionmentioning

confidence: 99%

Renal stones and calcifications in patients with primary hyperparathyroidism: associations with biochemical variables

Starup-Linde

Waldhauer

Rolighed

et al. 2012

European Journal of Endocrinology

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Objective: To study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications. Design: Cross-sectional. Materials and methods: All patients (nZ177) undergoing diagnostic evaluation and surgery for PHPT at Aarhus University Hospital between 2007 and 2009. All patients underwent routine spiral CT scans of the abdomen to determine the presence or absence of renal calcifications. Results: A total of 45 patients (25.4%, 95% confidence intervals: 19.0-31.4%) had renal stones (15.3%) and/or renal calcifications (10.2%) on the CT scans. Compared with those without calcification (nZ132), the group with calcification had a significantly lower plasma creatinine level (67.0G25.1 vs 74.6G17.5 mmol/l, 2PZ0.03). Moreover, CaE was higher in PHPT patients with renal calcification than in PHPT patients without (0.91G0.28 vs 0.74G0.40 mmol/mmol, 2PZ0.02). The other measured or derived biochemical variables were similar in the two groups. No biochemical variable was predictive for renal calcifications in a multiple regression analysis. Conclusion: We found a high prevalence of renal calcifications among PHPT patients but no deterioration of renal function. The occurrence of calcifications was related to low plasma creatinine and a high urine calcium/creatinine ratio. However, biochemical markers in general were poor predictors for the risk of renal stones or nephrocalcinosis indicating that routine image diagnostics may be needed for the identification of these complications in order to establish indication for surgery and ensure proper treatment.

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“…Its prevalence is commonly estimated at 1 in 1000 (22). However, the most recent estimations in Europe, from Scandinavia (23,24,25) and Scotland (26), suggest that the prevalence is instead 1% in the general population, and 3-4% in post-menopausal women.…”

Section: ) Phpt Is Now a Very Frequently Recognized Disordermentioning

confidence: 99%

Is surgery necessary for ‘mild’ or ‘asymptomatic’ hyperparathyroidism?

Niederle¹,

Wémeau

2015

European Journal of Endocrinology

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A large majority of the currently diagnosed patients with hyperparathyroidism (PHPT) are mild or asymptomatic, mainly women after menopause. Following the debate held at the 16th European Congress of Endocrinology in Wroclaw (Poland) from May 3-7, 2014, arguments are here presented by a surgeon and a medical practitioner considering these situations rather have to profit from surgery, or simply from survey. For the trained endocrine surgeon, it is evident that parathyroidectomy confirms the diagnosis and undoubtedly reduces the discomfort felt by certain patients, prevents all risks of complications, removes patients and medical teams from the monitoring and represents a real individual financial benefit. On the other hand, the medical practitioner considers that mild or asymptomatic PHPT is commonly stable, and very rare are the subjects at risk of complications, particularly of fractures; prevention of vascular and metabolic disorders, nephrolithiasis and bone rarefaction justify regular physical exercise, a safe alimentation, a sufficient calcium and high water intake, the correction of the frequent deficit in vitamin D; finally has also to be considered the impossibility to refer to specialized (endocrine) surgeons, the enormous cohort of subjects more than 50 years with 'mild' or 'asymptomatic' PHPT. The surgeon and the medical practitioner agree to consider that in patients with 'mild' or 'asymptomatic' disease, there is no place for medical treatments, in particular calcimimetics and bisphophonates. Both agree that further studies are needed to clarify the long-term prognosis of operated and non-operated PHPT in term of fractures, cardiovascular risk and mortality. Individual and collective cost/benefit ratios of surgery or survey are also still imperfectly evaluated.

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Epidemiology of primary hyperparathyroidism in Tayside, Scotland, UK

Abstract: We observed a general increase in the prevalence of diagnosed PHPT in Tayside, Scotland. The incidence of diagnosis is greater in females than in males and increases with age. The annual incidence followed an apparent cyclic curve during the study period.

Cited by 175 publications

References 22 publications

Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment

Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment

Renal stones and calcifications in patients with primary hyperparathyroidism: associations with biochemical variables

Is surgery necessary for ‘mild’ or ‘asymptomatic’ hyperparathyroidism?

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