Epidemiology of primary glomerular diseases in a French region. Variations according to period and age

Simon, Pierre; Ramée, M. P.; Autuly, Valérie; Laruelle, Éric; Charasse, Christophe; Cam, G.; Ang, K.S.

doi:10.1038/ki.1994.384

Cited by 158 publications

(123 citation statements)

References 12 publications

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“…Idiopathic MCGN is the most common biopsy finding in Cape Town [21] and in other areas of SA the second most common, [22] although it is declining in incidence in developed countries. [23] Known associations with MCGN did not explain the link between methamphetamine use and MCGN. All the biopsies that showed MCGN had IgM and C3 deposits, supporting chronic antigenaemia as a possible cause.…”

Section: Fig 1 Light Microscopic Features Of Kidney Changes Seen Inmentioning

confidence: 99%

Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users

Jones

Rayner

2015

S Afr Med J

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Background. Methamphetamine abuse has risen dramatically in South Africa. The chronic effects of abuse on the kidneys and blood pressure have not been documented. This study reviewed patients referred for evaluation of kidney disease and/or hypertension, who had been abusing methamphetamines. Methods. The records of patients referred to the renal unit between 2005 and 2013 who had been using methamphetamines were retrospectively reviewed. Patient demographics, biophysical parameters, blood pressure, renal function, renal ultrasound and biopsy findings, complications of chronic kidney disease and comorbidities were recorded. Results. Forty-seven patients were included in the study. Their mean age was 29 years. Hypertension was present in 42 (89.4%) of patients, with malignant hypertension in 21 (44.7%). Forty-five (95.7%) had chronic kidney disease (CKD), and 26 (55.3%) had end-stage renal disease. Renal biopsies were performed in 24 patients. Twelve (50.0%) of the biopsies showed hypertensive changes and 14 (58.3%) mesangiocapillary glomerulonephritis type 1, with deposition of IgM and C3 complement. Conclusion. Methamphetamine use is associated with severe hypertension, mesangiocapillary glomerulonephritis and CKD.

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Section: Fig 1 Light Microscopic Features Of Kidney Changes Seen Inmentioning

confidence: 99%

Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users

Jones

Rayner

2015

S Afr Med J

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“…12,13 Recently, an increasing number of studies demonstrate that the spectrum of biopsy-proven renal diseases has changed over the past three decades in other counties 7,11,[13][14][15][16][17][18][19][20][21][22][23] and in northern and southern China. 4,8,24,25 Nephrotic syndrome (NS) is reported to be the main indication for renal biopsy in other countries 10,12,14,22 and northern China, 4,24,26 except Japan, 6 where the leading indication is asymptomatic proteinuria and/or hematuria.…”

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confidence: 99%

Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Ning

Shi

et al. 2016

Renal Failure

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The purpose of this study is to investigate the changing spectrum and clinicopathologic correlation of biopsy-proven renal diseases in central China. We retrospectively analyzed data of 4931 patients who underwent renal biopsy in ten hospitals between September 1994 and December 2014. Among them, 81.55% were primary glomerular diseases (GD), and 13.02% were secondary GD. IgA nephropathy (IgAN) was the most common primary GD (43.45%), followed by focal glomerulonephritis (16.79%), mesangial proliferative glomerulonephritis (MsPGN, 14.35%), and membranous nephropathy (MN, 13.28%). IgAN was leading primary GD in patients under 60 years old, while MN was the leading one over 60 years old. The most frequent secondary GD was lupus nephritis (LN) (47.35%). The prevalence of IgAN, MN and minimal change disease was found to increase significantly (p < 0.001, p < 0.001, and p < 0.01, respectively), while that of MsPGN, membranoproliferative glomerulonephritis and LN decreased significantly (p < 0.001, p < 0.001, and p < 0.05, respectively). The main indication for renal biopsy was proteinuria and hematuria (49.03%), followed by nephrotic syndrome (NS, 20.36%). IgAN was the most common cause in patients with proteinuria and hematuria, chronic-progressive kidney injury, hematuria and acute kidney injury; and MN was the leading cause of NS. Primary GD remained the predominant renal disease in central China. IgAN and LN were the most prevalent histopathologic lesions of primary and secondary GD, respectively. The spectrum of biopsy-proven renal disease had a great change in the past two decades. Proteinuria and hematuria was the main indication for renal biopsy. ARTICLE HISTORY

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“…F ocal and segmental glomerulosclerosis (FSGS) is one of the most common causes of primary glomerular disease that terminates in renal failure (1,2). In most series, its 10-yr survival is in the 40 to 60% range (3)(4)(5)(6)(7).…”

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Focal and Segmental Glomerulosclerosis

Troyanov

Wall

Miller

et al. 2005

Journal of the American Society of Nephrology

242

211

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Focal and segmental glomerulosclerosis (FSGS) is one of the most common primary glomerular diseases to terminate in ESRD.A complete remission (CR) confers an excellent long-term prognosis, but the quantitative benefits of partial remissions (PR) have not been defined. This study evaluated the rate of renal function decline (slope of creatinine clearance) and renal survival in nephrotic FSGS patients with CR, PR, or no remission. It also examined relapse rate from remission and its impact on outcome. Multivariate analysis included clinical and laboratory data at presentation and over follow-up, BP control, the agents used, and immunosuppressive therapy. The study cohort was 281 nephrotic FSGS patients who had a minimum of 12 mo of observation and were identified from the Toronto Glomerulonephritis Registry. Over a median follow-up of 65 mo, 55 experienced a CR, 117 had a PR, and 109 had no remission. A PR was independently predictive of slope and survival from renal failure by multivariate analysis (adjusted time-dependent hazard ratio, 0.48; 95% confidence interval, 0.24 to 0.96; P ‫؍‬ 0.04). Immunosuppression with high-dose prednisone was associated with a higher rate of PR and CR. Relapse from PR was frequent (56%) and associated with a more rapid rate of renal function decline and worse renal survival compared with relapse-free partial remitters. Only female gender and the nadir of proteinuria during remission were associated with a sustained remission. A PR in proteinuria and its maintenance are important therapeutic targets in FSGS, with implications for both slowing progression rate and improving renal survival.J (FSGS) is one of the most common causes of primary glomerular disease that terminates in renal failure (1,2). In most series, its 10-yr survival is in the 40 to 60% range (3-7).Severity of proteinuria at onset and during follow-up have been associated with a poor outcome in several series (3-8).Although there is strong evidence that nephrotic patients who experience a complete remission (CR) have a very favorable prognosis (9 -11), the long-term outcome in adults with only a reduction in proteinuria has seldom been reported (11,12). Despite the lack of evidence of its value as a valid surrogate for improved renal survival in FSGS, it is often reported as a positive finding in clinical studies (11)(12)(13)(14).This study addresses the long-term implications of a partial remission (PR) in nephrotic FSGS patients. It compares the rate of renal function decline, relapse, renal failure, and treatment effects among patients with a PR, CR, and no remission (NR). Materials and MethodsAll FSGS patients from the Toronto Glomerulonephritis Registry were considered for this study. This database began in 1974 and includes all biopsy-proven cases of glomerulonephritis from the Toronto area. Patient information at onset is compiled using a standard form, and registrars perform a periodic prospective assessment of the patients' clinical status, medications, and laboratory results (15). We reviewed all previous m...

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Epidemiology of primary glomerular diseases in a French region. Variations according to period and age

Cited by 158 publications

References 12 publications

Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users

Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users

Analysis of 4931 renal biopsy data in central China from 1994 to 2014

Focal and Segmental Glomerulosclerosis

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