Epidemiology of pertussis in adolescents and adults in Turkey

Karagul, A.; Öğünç, Dilara; Midilli, Kenan; Öngüt, Gözde; Baysan, Betil Özhak; Dönmez, Levent; Dağlar, Duygu; Kuşkucu, Mert Ahmet; Bingöl, Ayşen; Özbudak, Ömer; Çolak, Dilek; Günseren, Filiz

doi:10.1017/s0950268814003483

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…Infants may also contract diseases from adolescents who have not been vaccinated. In a study involving 214 adolescents with prolonged cough, 7% of the participants had pertussis positivity [19]. Also, seroprevalence studies have shown that immunisations over the course of acellular pertussis were terminated within a mean of 5 years [20].…”

Section: Discussionmentioning

confidence: 99%

Social contact patterns of infants in deciding vaccination strategy: a prospective, cross-sectional, single-centre study

et al. 2018

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Social contact between individuals is believed to be a fundamental cause in the transmission of many respiratory tract infections. Because they have not yet been fully vaccinated, infants are at high risk for contracting whooping cough, influenza and their serious complications. Therefore, determining infant social contact patterns is an important step in protecting them from respiratory tract infection. This study included 1200 healthy infants (<12 months of age). Social contact diaries were used to estimate the frequency and nature of the infants' social contacts. This survey also gathered information regarding the infants' respiratory symptoms and their frequency of attendance at crowded places over a period of 1 week. The diary return rate was 83.8% (N = 1006), and there was a total of 4706 contacts reported for these infants. The median daily contact number per capita was 4 (range 1-18). The median number of contacts with adolescents was 0 (range 0-7). Of the infants, 50.3% had contact with non-household individuals. The mothers had the longest contacts with their babies. Contacts with school children, frequency of attendance at crowded places and age were determined to be significant effective factors for reporting respiratory symptoms. Results suggest that school-age siblings and the mothers should be primarily vaccinated, and parents should keep their babies away from crowded places for protecting their infants.

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Section: Discussionmentioning

confidence: 99%

Social contact patterns of infants in deciding vaccination strategy: a prospective, cross-sectional, single-centre study

et al. 2018

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“…However, the prevalence of pertussis has been found to be increased in adolescents and adults with prolonged cough in many LMICs. 46,100,101 Asymptomatic pertussis infections are also common in school children aged 7-15 y old, as showed in a recent Chinese study. 102 Similar to the findings in developed countries, 103 although reported incidences are mostly <1/100 000, true incidences estimated by seroprevalence studies are much higher, especially in adolescents and adults populations.…”

Section: Immune Persistence After Vaccination With Wpsmentioning

confidence: 77%

Immune persistence after pertussis vaccination

Chen

2017

Human Vaccines & Immunotherapeutics

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Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs due to variation in vaccine content, schedule and coverage. Protection following acellular pertussis vaccines has been suggested to wane faster than whole cell pertussis vaccines. However, long-term immune persistence of whole cell pertussis vaccines may be confounded by a progressive acquisition of natural immunity. The World Health Organization has recommended that a switch from whole cell to acellular pertussis vaccines for primary immunization in infants should only be considered if additional periodic boosters or maternal immunization can be ensured and sustained in the national immunization schedules. In this review, we present data on immune persistence after different pertussis vaccinations and compare the findings from countries with different vaccination strategies. Future aspects in serological studies are briefly discussed.

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“…The mean prevalence of pertussis was found to be 3% (0% to 6.2%) in adults with cough duration between 2 to 4 weeks in a European multicentre study [ 11 ]. In a study evaluating 214 adolescent and adult patients with cough duration of more than 2 weeks, pertussis PCR was found to be positive in 15 (7%) subjects [ 12 ]. Another study evaluating pertussis seroprevalence in adults, 52 (9.7%) of 538 patients with cough duration for more than 2 weeks suggested that their B. pertussis antibody levels were compatible with acute or recent infection [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Pertussis prevalence among adult patients with acute cough

İLBAY¹,

TANRIÖVER²,

ZARAKOL³

et al. 2022

Turkish Journal of Medical Sciences

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Background/aim Bordetella pertussis infection remains an important health problem in adults due to the increasing prevalence in recent years. Pertussis in adults can be easily overlooked or misdiagnosed. We aimed to determine the prevalence of pertussis in adult patients with acute cough and the clinical features of the pertussis cases. Materials and methods Internal Medicine and Pulmonology inpatient wards and outpatient clinics were screened between March 2017 and June 2018. Patients with cough duration between 1 week and 1 month were enrolled. Those who were on antibiotics for more than 5 days were excluded. A total of 115 patients were enrolled. Nasopharyngeal swabs were taken and real-time polymerase chain reaction analyses were done. Results According to the pertussis case definition, 47.8% of the patients were diagnosed with probable pertussis. We found the prevalence of pertussis as 3.5% in our cohort. All of the patients with pertussis had a history of paroxysmal cough with a mean duration of 20 days. Conclusions These results show that pertussis continues to be a health problem for adults and may present with acute cough. The growing number of adult pertussis cases suggest that vaccination of children is inadequate to prevent pertussis and the concept of ‘lifelong vaccination’ should be strengthened.

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Epidemiology of pertussis in adolescents and adults in Turkey

Cited by 13 publications

References 19 publications

Social contact patterns of infants in deciding vaccination strategy: a prospective, cross-sectional, single-centre study

Social contact patterns of infants in deciding vaccination strategy: a prospective, cross-sectional, single-centre study

Immune persistence after pertussis vaccination

Pertussis prevalence among adult patients with acute cough

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