Epidemiology of multiple sclerosis in western Herzegovina

Klupka-Šarić, Inge; Ristić, Smiljana; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut; Materljan, Eris; Jurišić, Tonka; Mamić, Dražena Martinović; Burina, Adnan; Šulentić, Vlatko

doi:10.1016/j.clineuro.2007.07.014

Cited by 17 publications

(18 citation statements)

References 14 publications

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“…Fourteen of the studies included in this review were from South East Europe, covering the former Yugoslavia [130,131], Croatia [132-134], Slovenia [134], Bosnia and Herzegovina [135,136], Bulgaria [16,137], Romania [11], Greece [138,139], and Greek- and Turkish-speaking communities in Cyprus [23,24]. …”

Section: Resultsmentioning

confidence: 99%

Incidence and prevalence of multiple sclerosis in Europe: a systematic review

et al. 2013

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BackgroundMultiple sclerosis (MS) is the most common cause of neurological disability in young adults worldwide and approximately half of those affected are in Europe. The assessment of differential incidence and prevalence across populations can reveal spatial, temporal and demographic patterns which are important for identifying genetic and environmental factors contributing to MS. However, study methodologies vary and the quality of the methods can influence the estimates. This study aimed to systematically review European studies of incidence and prevalence of MS and to provide a quantitative assessment of their methodological quality.MethodsA comprehensive literature search was performed to obtain all original population-based studies of MS incidence and prevalence in European populations conducted and published between January 1985 and January 2011. Only peer-reviewed full-text articles published in English or French were included. All abstracts were screened for eligibility and two trained reviewers abstracted the data and graded the quality of each study using a tool specifically designed for this study.ResultsThere were 123 studies that met the inclusion criteria. The study estimates were highly heterogeneous, even within regions or countries. Quality was generally higher in the more recent studies, which also tended to use current diagnostic criteria. Prevalence and incidence estimates tended to be higher in the more recent studies and were higher in the Nordic countries and in northern regions of the British Isles. With rare exceptions, prevalence and incidence estimates were higher in women with ratios as high as 3:1. Few studies examined ethnicity. Epidemiological data at the national level was uncommon and there were marked geographical disparities in available data, with large areas of Europe unrepresented and other regions well-represented in the literature. Only 37% of the studies provided standardized estimates.ConclusionsDespite the breadth of the literature on the epidemiology of MS in Europe, inter-study comparisons are hampered by the lack of standardization. Further research should focus on regions not yet studied and the evaluation of ethnic differences in MS prevalence and incidence. National-level studies using current diagnostic criteria, validated case definitions and similar age- and sex-standardization would allow better geographical comparisons.

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Section: Resultsmentioning

confidence: 99%

Incidence and prevalence of multiple sclerosis in Europe: a systematic review

et al. 2013

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“…Hence, in Europe a significant increase of MS prevalence is seen between the degrees 45 and 65 of latitude towards the north, in North America at 38 degrees, Russia 50 degrees (13). Geographical extension of MS in Kosovo is in 43 degrees of latitude, and when compared to the above mentioned research it is slightly lower than the limits of latitude distribution of the disease in Europe and countries in the region as is Serbia (14) Croatia (9), Bosnia and Herzegovina (7,8), and Slovenia (6). Even though the same distribution goes for the south too, the other half of the globe has not been yet studied to detail.…”

Section: Discussionmentioning

confidence: 59%

“…This prevalence is approximate when compared to the MS prevalence in the countries of the region, example Albania (15), Slovenia (6), Serbia (14) , Bosnia and Herzegovina (7,8) , Croatia (9) , while it is considerately lower than countries with higher prevalence, such as Scandinavian countries, Norway (16,17) and those of Central Europe, such as Germany (18), France (19, 20). …”

Section: Discussionmentioning

confidence: 90%

“…In Shumadia, in 2006, the prevalence of MS was 64.9/100.000 (5). Some studies regarding the prevalence of MS in Croatia and Slovenia, especially at the territory of Gorski Kotor and Kocevia the prevalence of MS was high 150/100.000 (6), Bosnia and Herzegovina (7, 8), in all other regions is reported fare more low prevalence of MS for example in Croatia region the prevalence of MS for the period 1962-2000 was around 25-53/100.000 (9) while for Bosnia and Herzegovina it was some 31-49.6/100.000 (7, 8). …”

Section: Introductionmentioning

confidence: 99%

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Epidemiological Characteristics and Functional Disability of Multiple Sclerosis Patients in Kosovo

Zeqiraj

Kruja

Kabashi

et al. 2014

Med Arh

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Background and objectives:Multiple Sclerosis (MS) is a chronic recurrent neurological disease that affects the Central Nervous System. This study aims to determine epidemiological factors that affect the appearance of MS, such as: incidence, prevalence, mortality, case appearance in accordance with the disease phase RRMS, SPMS, PPMS, gender, age, age group, and EDSS.Materials and methods:Deals with analyzing diagnosed and treated patients in the Clinic of Neurology in Prishtina during the period of 2003-2012. The research was conducted through a questionnaire applied in the diagnosed cases of MS. Information on patients was gathered from: history of illness, discharge reports and other relevant documents on MS illness. Clinical and epidemiological-descriptive study methods were used. The acquired results are shown through tables, graphics. Statistical processing was conducted with Microsoft Office Excel.Results:From the total number of doubtful hospitalized cases of demyelinization (644) in the Clinic of Neurology in Prishtina, 412 cases (64%) were diagnosed with MS. For the period of 2003–2012 the prevalence of MS has been 19.6 of patients in 100,000 inhabitants. MS incidence rate was 0.95 of patients in 100,000 inhabitants. MS mortality rate was 0.14 of deceased in 100,000 inhabitants. The ratio female – male is 2.3:1. A larger number of patients fall within the age group of 30-39 years-old. Clinical form trends: RRSM 72.3%, SPSM 22.6%, PPSM 5.1%. The rate of EDSS 78.3% (0–3.5), 14.9% (4–6.5), 6.8% (7–9).

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“…Apart from this exception, other recent studies from Croatia showed a range of rates from 25 to 53 per 100,000 in the time period of 1969-2000 [11] . Results of the study from two cantons in Bosnia and Herzegovina (in the period from 1996 to 2006, using the criteria of McDonald [6] , published in local scientific literature) revealed that the crude prevalence of MS was 31.0/100,000, with the highest one in the municipality of Posusje (49,6/100,000) and the lowest one in the municipalities of Neum and Ravno (no recorded cases) [12] . The same investigators previously reported an MS prevalence of 27/100,000 in western Hercegovina, on prevalence day, 31 December 2003 [13] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Multiple Sclerosis in the Serbian District Sumadija

et al. 2011

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Background: The aim of this study was to estimate the prevalence of multiple sclerosis (MS) in the district of Sumadija (central part of Serbia). Methods: All persons suffering from MS, with permanent residence in the region, were recruited. Prevalence was calculated on December 31, 2006, according to a standard procedure. Results: On December 31, 2006, one hundred ninety-four patients (72 males and 122 females) were found to have MS. We found a crude MS prevalence of 64.9/100,000 (49.3/100,000 for males and 79.9/ 100,000 for females). The highest prevalence rates were registered in the age group of 30–39 years for females and 40–49 years for males, although the age-specific rates were higher in females in all age groups. The mean age at onset was 34.2 ± 9.3 years. The average duration of MS was 8.9 ± 6.2 years. The median EDSS score was 3.9 ± 2.0. The course of MS was relapsing-remitting in 63.9% of patients, secondary progressive in 32.5%, and primary progressive in 3.6%. At MS onset, motor symptoms were present in 70.1% of patients, sensory in 40.7%, cerebellar in 21.1%, brainstem in 15.5%, visual in 22.2%, and bowel/bladder disturbances in 22.2%. Conclusions: Our results demonstrate that the MS prevalence registered in the Serbian district Sumadija is similar to that of other surrounding areas in Southeastern Europe.

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Epidemiology of multiple sclerosis in western Herzegovina

Cited by 17 publications

References 14 publications

Incidence and prevalence of multiple sclerosis in Europe: a systematic review

Incidence and prevalence of multiple sclerosis in Europe: a systematic review

Epidemiological Characteristics and Functional Disability of Multiple Sclerosis Patients in Kosovo

Prevalence of Multiple Sclerosis in the Serbian District Sumadija

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