Epidemiology of Large Bowel Carcinoid Tumors in the USA: A Population-Based National Study

Lal, Pooja; Saleh, Mohannad Abou; Khoudari, George; Gad, Mohamed M.; Mansoor, Emad; Isenberg, Gerard; Cooper, Gregory S.

doi:10.1007/s10620-019-05725-0

Cited by 14 publications

(5 citation statements)

References 31 publications

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“…Use of the Explorys platform has been validated in hematology, 25 cardiology, 26 and gastroenterology. 27 Multiple studies have been done in IBD population using Explorys, and the results of the prevalence and the demographic characteristics were similar to previous findings, suggesting a representative sampling. 26,28 Explorys is a Health Insurance Portability and Accountability Act-compliant platform using de-identified EMR data, and studies arising from Explorys platform were deemed exempt by the University Hospitals Institutional Review Board.…”

Section: Study Design and Data Sourcesupporting

confidence: 82%

Rates of Intestinal Resection and Colectomy in Inflammatory Bowel Disease Patients After Initiation of Biologics: A Cohort Study

Khoudari¹,

Mansoor

Click

et al. 2022

Clinical Gastroenterology and Hepatology

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Section: Study Design and Data Sourcesupporting

confidence: 82%

Rates of Intestinal Resection and Colectomy in Inflammatory Bowel Disease Patients After Initiation of Biologics: A Cohort Study

Khoudari¹,

Mansoor

Click

et al. 2022

Clinical Gastroenterology and Hepatology

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“…Similarly, in a large retrospective study from US-based population database of electronic medical records of 62,817,650 individuals from 26 major healthcare institutions, 4530 of them were reported to have a large colonic carcinoid diagnosis and, in several cases, a personal history of CD or ulcerative colitis. For these subjects an increased risk to develop large bowel carcinoid was observed: OR 6.93 (95% CI 5.55-8.64, p < 0.0001) and OR 6.45 (95% CI 5.24-7.95, p < 0.0001), respectively [171]. Sciola et al reported a prevalence for IBD of 4.8% in a series of 83 GEP NENs.…”

Section: Ibd and Nensmentioning

confidence: 93%

From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?

Mantovani

Dicitore

Barrea

et al. 2020

Rev Endocr Metab Disord

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Gut microbiota is represented by different microorganisms that colonize the intestinal tract, mostly the large intestine, such as bacteria, fungi, archaea and viruses. The gut microbial balance has a key role in several functions. It modulates the host’s metabolism, maintains the gut barrier integrity, participates in the xenobiotics and drug metabolism, and acts as protection against gastro-intestinal pathogens through the host’s immune system modulation. The impaired gut microbiota, called dysbiosis, may be the result of an imbalance in this equilibrium and is linked with different diseases, including cancer. While most of the studies have focused on the association between microbiota and gastrointestinal adenocarcinomas, very little is known about gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs). In this review, we provide an overview concerning the complex interplay between gut microbiota and GEP NENs, focusing on the potential role in tumorigenesis and progression in these tumors.

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“…In addition, SNOMED-CT allows for more concepts to be coded per clinical document compared to ICD making it more accurate in terms of documenting diagnoses and pertinent patient information. It is important to highlight that Explorys has been validated previously as a database (59) and in different specialties including gastroenterology (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)60,61).…”

Section: Discussionmentioning

confidence: 99%

“…To keep patients' information confidentiality, Explorys rounds cell counts to the nearest 10. Explorys database has been validated previously in multiple fields including surgery and gastroenterology (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Databasementioning

confidence: 99%

Epidemiology of gallbladder cancer in the Unites States: a population-based study

Alkhayyat¹,

Saleh²,

Qapaja³

et al. 2021

Chin Clin Oncol

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Background: Gallbladder cancer (GBC) is the most common neoplasm of the biliary tract with the lowest rates of survival. Most GBCs are adenocarcinomas that arise from the epithelial lining of the gallbladder. There are limited data in the literature regarding the epidemiology of GBC. Using a large database, we aim to describe the epidemiology using a US population database. Methods: A multi-institutional database (Explorys Inc., Cleveland, OH, USA) was surveyed. A cohort of patients with a primary malignant neoplasm of gallbladder between 1999-2019 was identified. The prevalence rate was calculated and age-, race-, and sex-based distributions were described. Multivariate analysis was done to evaluate underlying associations. Results: Of the 56,197,690 individuals in the database, 4,790 individuals with GBC were identified with a prevalence rate of 8.5 per 100,000. Asian race has the highest prevalence of GBC (13.6/100,000). Patients with GBC were also more likely to be smokers, have a history of alcohol abuse, obesity, diabetes, cholelithiasis, chronic cholecystitis, primary sclerosing cholangitis (PSC), and chronic viral hepatitis. Conclusions: This is one of the largest US population studies to date evaluating the epidemiology of GBC. The 20-year period prevalence rate of GBC was 8.5 per 100,000. Patients with GBC were more likely to be elderly, females, obese, diabetic, and have chronic hepatobiliary disorders.

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Epidemiology of Large Bowel Carcinoid Tumors in the USA: A Population-Based National Study

Cited by 14 publications

References 31 publications

Rates of Intestinal Resection and Colectomy in Inflammatory Bowel Disease Patients After Initiation of Biologics: A Cohort Study

Rates of Intestinal Resection and Colectomy in Inflammatory Bowel Disease Patients After Initiation of Biologics: A Cohort Study

From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?

Epidemiology of gallbladder cancer in the Unites States: a population-based study

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