Epidemiology of gallbladder cancer in the Unites States: a population-based study

Abstract

Background: Gallbladder cancer (GBC) is the most common neoplasm of the biliary tract with the lowest rates of survival. Most GBCs are adenocarcinomas that arise from the epithelial lining of the gallbladder. There are limited data in the literature regarding the epidemiology of GBC. Using a large database, we aim to describe the epidemiology using a US population database. Methods: A multi-institutional database (Explorys Inc., Cleveland, OH, USA) was surveyed. A cohort of patients with a primary malignant neoplasm of gallbladder between 1999-2019 was identified. The prevalence rate was calculated and age-, race-, and sex-based distributions were described. Multivariate analysis was done to evaluate underlying associations. Results: Of the 56,197,690 individuals in the database, 4,790 individuals with GBC were identified with a prevalence rate of 8.5 per 100,000. Asian race has the highest prevalence of GBC (13.6/100,000). Patients with GBC were also more likely to be smokers, have a history of alcohol abuse, obesity, diabetes, cholelithiasis, chronic cholecystitis, primary sclerosing cholangitis (PSC), and chronic viral hepatitis. Conclusions: This is one of the largest US population studies to date evaluating the epidemiology of GBC. The 20-year period prevalence rate of GBC was 8.5 per 100,000. Patients with GBC were more likely to be elderly, females, obese, diabetic, and have chronic hepatobiliary disorders.

Causal effect of autoimmune liver diseases on cancer: Meta‐analyses of cohort studies and Mendelian randomization study

“…These results consisted of a recently published study and previous studies. 2,[20][21][22][23] and cancer risk, and the results also suggested a 21-fold and 42-fold increased risk of hepatobiliary cancers in patients with AIH and PBC respectively. 20 In addition, sensitivity analyses suggested that the results were stable (AIH: RR = 12, PBC: RR = 14).…”

“…In this study, patients with AiLD were mainly reported to be associated with hepatobiliary cancers, and we found a 22‐fold higher risk of hepatobiliary cancers in these patients (AIH: RR = 12, PBC: RR = 16, PSC: RR = 139). These results consisted of a recently published study and previous studies 2,20–23 . It is noteworthy that the recent study published in JAMA Oncology investigated the relationship between immune‐mediated diseases (including AIH and PBC) and cancer risk, and the results also suggested a 21‐fold and 42‐fold increased risk of hepatobiliary cancers in patients with AIH and PBC respectively 20 .…”

Target nursing care on anxiety and depression in patients with gallbladder cancer during perioperative period

“…Globally, GBC is a rare, but aggressive malignancy of the biliary tract. [1][2][3][4][5] Epidemiological studies reported that its incidence and prevalence increase annually. [30][31][32] Thus, the management of this fatal disease is urgent.…”

“…Gallbladder cancer (GBC) is the most common distinct subset of biliary tract cancer worldwide. [1][2][3] It is a rare but highly lethal malignant disease with a worldwide incidence of 2 per 100,000 persons. [4][5][6][7] In addition, its incidence is relatively high, with a significant geographic variation.…”

Examination of the characteristics of long-term survivors among patients with gallbladder cancer with liver metastasis who underwent surgical treatment: a retrospective multicenter study (ACRoS1406)

“…Gallbladder cancer (GBC) is the most common biliary malignancy and the sixth most common gastrointestinal malignancy, with a prevalence rate ranging from 8.5 cases per 100,000 population in the United States (US) to 13.6 cases per 100,000 in Asian populations [ 1 ]. GBC occurs relatively often in certain geographic locations, such as Chile, North India, South Korea, Japan, and New Mexico (US) [ 2 ].…”