Epidemiology of Humanpapilloma virus infection among women in Fujian, China

Abstract

BackgroundHuman papillomavirus (HPV) infection is the main etiological factor for the development of cervical cancer. Here we assessed the prevalence and distribution of HPV genotypes in Fujian population.MethodsA total of 8678 women aging from 17 to 84 years olds were recruited from the Fujian Medical University Union Hospital in Fujian Province. Every woman had a face-to-face interview. Cervical samples were collected from each participant and HPV screening was conducted using microarray hybridization.ResultsOur study showed that the HPV prevalence in Fujian province was 38.3%. Among the positive individuals, 70.6% were detected for single HPV infection, 29.4% for multiple HPV infections. Further analysis showed that the prevalence of HPV infection significantly increased from 2009 to 2015. The four most common high risk human papillomavirus (HR-HPV) genotypes were HPV16 (8.5%), HPV52 (7.9%), HPV58 (6.2%), HPV 53 (3.5%), collectively accounting for 60.5% of all detected HPV infection. Age subgroup analysis showed two peaks for the frequencies of overall and multiple HPV infections, one for the group of women under 25 years old, and the other for the group over 55 years old.ConclusionsHPV infection is becoming serious in Fujian province, which indicates the imperative to implement a HPV vaccination and screening program for this region.

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

“…The HPV infection rate varies markedly in China due to its large population and territory. Our results showed that the prevalent detection of any HPV subtypes among gynecological outpatients in Guangdong was 20.16%, which was higher than HPV prevalence in Hubei (17.68%) and lower than that in Fujian (38.3%) and Zhejiang (22.3%) . Considering the same laboratory method (Chaozhou Hybribio Limited Corporation, Chaozhou, China) in HPV detection among these studies, the diversity in HPV prevalence might mainly be attributed to geographical variation.…”

“…For example, in Zhejiang province, the main genotypes of HR HPV were HPV16, 52, 58, 53, and 18 . In Fujian province, the main genotypes of HR HPV were HPV16, 52, 58, 53, and 33 . In Hubei province, the main genotypes of HR HPV were HPV 52, 16, 58, 39, and 51 .…”

“…Then, the HPV infection rate declines as age increases and stabilized among women aged 25 to 44 years. This may account for their mature immunity to HPV with the ability to prevent or clear HPV infections . What's more, women aged 25 to 44 years are more frequent to attend the clinic because they are in the reproductive age, which makes them more health‐savvy.…”

“…For participants detected with multiple HPV genotypes, HPV positivity was calculated for individual HPV genotypes. In the calculation of HPV positivity in a given year, for each woman, we only included the result from her first test in that particular year to avoid the problem about repeated HPV detection in the same year . Then, we calculated prevalent HPV detection by dividing the number of HPV positive cases by the total number of individuals tested for HPV.…”

Prevalence and distribution of human papillomavirus genotypes among women with high‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China

“…However, in different countries and regions, the distribution of HPV genotypes in cervical cancer and precancerous lesion varies was different . Many studies proved that the genotype distribution of HPV differed in the various provinces of China . The most frequent hr‐HPV genotypes were HPV 16 and HPV 58, HPV 52 and HPV 16, HPV 16 and HPV 18, and HPV 16 and HPV 52 in Shanxi, Sichuan, Jiangxi, and Fujian province, respectively.…”