Epidemiology of human enterovirus 71 infections in France, 2000–2009

Schuffenecker, Isabelle; Mirand, Audrey; Antona, Denise; Henquell, Cécile; Chomel, Jean-Jacques; Archimbaud, Christine; Billaud, Geneviève; Peigue-Lafeuille, H.; Lina, Bruno; Bailly, Jean‐Luc

doi:10.1016/j.jcv.2010.09.019

Cited by 56 publications

(45 citation statements)

References 32 publications

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“…Phylogenetic analyses were carried out as previously described. 19 Bootscan analyses on the genomes of our EV71 and CA16 isolates were conducted as previously described. 20 …”

Section: Sequencing and Phylogenetic Analysismentioning

confidence: 99%

Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008–2011

Yin

et al. 2012

Journal of Clinical Virology

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“…Phylogenetic analyses were carried out as previously described. 19 Bootscan analyses on the genomes of our EV71 and CA16 isolates were conducted as previously described. 20 …”

Section: Sequencing and Phylogenetic Analysismentioning

confidence: 99%

Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008–2011

Yin

et al. 2012

Journal of Clinical Virology

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“…However, unlike other members of EV-A, EV71 infections are associated in a small proportion of subjects with a wide array of severe disease presentations, including aseptic meningitis, encephalitis, and acute flaccid paralysis (AFP) (reviewed in references 29 and 58). Severe and fatal EV71 infections are predominantly found in young children, with male patients outnumbering female patients (12,52). There has been a substantial increase in the frequency and severity of EV71 epidemics in recent years, particularly in the Asian Pacific region (5,13,58,65), prompting urgent, ongoing investigations of the virological and host factors contributing to the apparently increasing pathogenicity of the virus (5,11,58).…”

mentioning

confidence: 99%

The Association of Recombination Events in the Founding and Emergence of Subgenogroup Evolutionary Lineages of Human Enterovirus 71

Leitch

Cabrerizo

Cardosa

et al. 2012

J Virol

109

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Enterovirus 71 (EV71) is responsible for frequent large-scale outbreaks of hand, foot, and mouth disease worldwide and represent a major etiological agent of severe, sometimes fatal neurological disease. EV71 variants have been classified into three genogroups (GgA, GgB, and GgC), and the latter two are further subdivided into subgenogroups B1 to B5 and C1 to C5. To investigate the dual roles of recombination and evolution in the epidemiology and transmission of EV71 worldwide, we performed a largescale genetic analysis of isolates (n ‫؍‬ 308) collected from 19 countries worldwide over a 40-year period. A series of recombination events occurred over this period, which have been identified through incongruities in sequence grouping between the VP1 and 3Dpol regions. Eleven 3Dpol clades were identified, each specific to EV71 and associated with specific subgenogroups but interspersed phylogenetically with clades of coxsackievirus A16 and other EV species A serotypes. The likelihood of recombination increased with VP1 sequence divergence; mean half-lives for EV71 recombinant forms (RFs) of 6 and 9 years for GgB and GgC overlapped with those observed for the EV-B serotypes, echovirus 9 (E9), E30, and E11, respectively (1.3 to 9.8 years). Furthermore, within genogroups, sporadic recombination events occurred, such as the linkage of two B4 variants to RF-W instead of RF-A and of two C4 variants to RF-H. Intriguingly, recombination events occurred as a founding event of most subgenogroups immediately preceding their lineage expansion and global emergence. The possibility that recombination contributed to their subsequent spread through improved fitness requires further biological and immunological characterization.

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“…EV-A71 infections have been detected in Europe, including in Denmark, France, Spain and the Netherlands, and although the incidence of EV-A71 infections is low, occasional lethal cases have already been reported [56][57][58][59]. Interestingly, German researchers recently described a case of paediatric encephalitis caused by a novel EV-A71 genotype that likely arose from a recombination event [60].…”

Section: Enterovirus 71 and Coxsackievirus A16mentioning

confidence: 99%

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

Anastasina

Domanska

Palm

et al. 2017

Journal of General Virology

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Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s. In this review we focus on enterovirus 71, coxsackievirus A16, enterovirus 68 and human parechovirus 3, which have recently drawn attention because of their links to severe neurological diseases. We discuss the clinical relevance of these viruses and the primary role of humoral immunity in controlling them, and summarize current knowledge on the neutralization of such viruses by antibodies.

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Epidemiology of human enterovirus 71 infections in France, 2000–2009

Cited by 56 publications

References 32 publications

Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008–2011

Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008–2011

The Association of Recombination Events in the Founding and Emergence of Subgenogroup Evolutionary Lineages of Human Enterovirus 71

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

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