Epidemiology of hidradenitis suppurativa in Germany – an observational cohort study based on a multisource approach

Kirsten, Natalia; Petersen, J.; Hagenström, Kristina; Augustin, Matthias

doi:10.1111/jdv.15940

Cited by 50 publications

(70 citation statements)

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“…[4][5][6] The disease presents usually after puberty, typically in the second and third decade of life, with a slight female predominance. 1,[3][4][5] Prevalence of HS varies among different older studies from 0.00033 to 4%, [7][8][9] and a mean disease incidence of 6.0 per 100 000 person-years has been reported. 1 Recent large epidemiological analysis in Germany and the USA revealed a HS prevalence of 0.03% and 0.053%, respectively, 7,10 and an incidence of 0.03% in 2015 with highest rates among women and in the age group of 30-40 years.…”

Section: Introductionmentioning

confidence: 99%

“…1,[3][4][5] Prevalence of HS varies among different older studies from 0.00033 to 4%, [7][8][9] and a mean disease incidence of 6.0 per 100 000 person-years has been reported. 1 Recent large epidemiological analysis in Germany and the USA revealed a HS prevalence of 0.03% and 0.053%, respectively, 7,10 and an incidence of 0.03% in 2015 with highest rates among women and in the age group of 30-40 years. 7 In the German study, low numbers of children and adolescents with HS were documented.…”

Section: Introductionmentioning

confidence: 99%

“…1 Recent large epidemiological analysis in Germany and the USA revealed a HS prevalence of 0.03% and 0.053%, respectively, 7,10 and an incidence of 0.03% in 2015 with highest rates among women and in the age group of 30-40 years. 7 In the German study, low numbers of children and adolescents with HS were documented. Indeed, early-onset HS is relatively uncommon with an incidence of 2.7 per 100 000 person-years among a paediatric population according to another recent American study.…”

Section: Introductionmentioning

confidence: 99%

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Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature

Vaiopoulos

Nikolakis

Zouboulis

2020

Acad Dermatol Venereol

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Background Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle affecting apocrine glands‐rich areas of the body. The disease usually occurs after puberty leading to painful nodules, abscesses, tunnels and scarring. Although uncommonly, HS can also occur in children and adolescents. Objective Our objective was to describe the epidemiology, characteristics, predisposing factors and clinical course of HS in paediatric patients. Methods The retrospective cohort study included patients with HS, who have been diagnosed in Dessau Medical Center and reported development of HS during childhood or adolescence, fulfilled the diagnostic criteria for HS and had a follow‐up period of at least one year. A systematic review was conducted on MEDLINE, EMBASE and CENTRAL on 19 March 2020 using the terms ‘hidradenitis’ or ‘acne inversa’ together with the terms ‘children’, ‘paediatric’ and ‘adolescence’. Results Twenty paediatric patients [1 child (0.22%), 19 adolescents (4.25%)] were detected out of 447 patients evaluated (4.5%) with a male to female ratio of 1.86 : 1. The median age at diagnosis was 17 years [interquartile range (IQR) 16–18] and the median age at onset 15 years (IQR: 14–16.5). The majority of the patients suffered from moderate disease were overweight or obese and non‐smokers. The most common comorbid disorder was acne vulgaris. The systematic review revealed reports with data heterogeneity and lack of systematic documentation of specific demographic characteristics. Most paediatric patients were female, obese and non‐smokers, with considerable comorbid disorders. Conclusions Hidradenitis suppurativa in Germany may affect children and adolescents exhibiting a particular phenotype of mainly male non‐smokers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature

Vaiopoulos

Nikolakis

Zouboulis

2020

Acad Dermatol Venereol

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“…This may be also impacted by the fact that HS was not exclusively diagnosed by dermatologists, e.g., in case of HS diagnosis in the hospital. Prevalence of HS calculated from other German SHI data showed similar incidence and prevalence and estimated the rate of potential misdiagnosis of HS at 34.7% [49]. The analyzed HIC data do not allow assessment of the influence of ethnicity, the patient's profession, educational level, subtypes of HS, laboratory data, or the duration or severity of both diseases on the prevalence of different comorbidities.…”

Section: Discussionmentioning

confidence: 80%

Hidradenitis Suppurativa and Concurrent Psoriasis: Comparison of Epidemiology, Comorbidity Profiles, and Risk Factors

Pinter

Kokolakis

Rech

et al. 2020

Dermatol Ther (Heidelb)

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Introduction: Hidradenitis suppurativa (HS) is a chronic, debilitating, and inflammatory skin disease. The epidemiology of HS varies greatly, with an estimated prevalence ranging from 0.03% to 4% worldwide. Similar to psoriasis (PsO), HS also exhibits a systemic inflammatory nature with a spectrum of systemic comorbidities. A large health insurance claims (HICs) database is analyzed to determine the demography and epidemiology of HS, PsO, and HS with concurrent PsO (HS-PsO) patients. Furthermore, the comorbidity profiles, including the comorbidity risk of these patient populations, are analyzed. Methods: This is a noninterventional retrospective analysis of anonymized HICs data using a subset of the Institute of Applied Health Research Berlin (InGef) database. The primary outcome is the prevalence and incidence of HS, PsO, and HS-PsO. Secondary outcomes include comorbidity profiles and a comorbidity risk analysis. Results: The prevalence and incidence of HS were 0.0681% and 0.0101%, respectively. The prevalence of HS-PsO was 0.004% (6% of the total HS population). HS patients frequently suffered from arterial hypertension (45%), nicotine dependence (46%), obesity (41%), and depression (36%), which were more common in HS-PsO patients compared with HS alone. HS patients had an increased prevalence of metabolic, psychiatric, immune-mediated, and cardiovascular diseases, e.g., overweight/obesity [odds ratio (OR): 2.65, 95% confidence interval (CI) 2.37-2.96], depression (OR: 1.55, 95% CI 1.42-1.76), or seronegative rheumatoid arthritis (OR: 2.82, 95% CI 1.61-4.94) compared with Digital Features To view digital features for this article go to

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“…A literature search returned 932 potentially relevant studies of which 12 studies [19][20][21][22][23][24][25][26][27][28][29][30] were included in the meta-analysis ( Fig. 1, Table 1): three cohort and nine cross-sectional studies.…”

Section: Study Selectionmentioning

confidence: 99%

Incidence and Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-analysis

Gill

Gniadecki

2019

Preprint

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Background: Hidradenitis is a chronic relapsing follicular occlusive disease with a widely variable reported prevalence. The exact prevalence and incidence of HS is unknown. Objectives: To perform a systematic review and meta-analysis of the published literature to estimate the global incidence and prevalence of HS. Methods: Literature searches were performed on Medline, Embase, and Pubmed to identify studies reporting incidence and/or prevalence of HS. Pooled estimates of prevalence and incidence were calculated with a meta-analysis of proportions. Results: In total, 12 studies were included (Australia, Brazil, Denmark, France, Germany, Ireland, Israel, UK, USA) comprising a total population of 53,805,690. Eleven studies reported prevalence. The pooled proportion of individuals in the general population with HS was 0.36% (95% CI: 0.21, 0.56). Self-reported HS gave a higher prevalence estimate than clinician-diagnosed HS. HS is more prevalent in women. Average annual incidence of HS was 28.5 cases/100,000 (95% CI: 26.8, 30.1). Conclusions: We estimated the global prevalence of HS to be 0.36% with 3:2 female predominance and average annual incidence to be 28.5 cases/100,000

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Epidemiology of hidradenitis suppurativa in Germany – an observational cohort study based on a multisource approach

Cited by 50 publications

References 22 publications

Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature

Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature

Hidradenitis Suppurativa and Concurrent Psoriasis: Comparison of Epidemiology, Comorbidity Profiles, and Risk Factors

Incidence and Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-analysis

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