Epidemiology of Hepatitis B Virus in the Middle East

Gençdal, Genco; Yurdaydın, Cihan

doi:10.1007/978-3-030-78737-0_5

Cited by 3 publications

(3 citation statements)

References 48 publications

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“…The first explanation is regarding the differences in antiviral treatment between the two countries. In Turkey, the national hepatitis B vaccination program was launched in 1998 and the endemic positive rates have decreased since then 26 . Thus, there have been 25 years of neonatal HBV vaccination.…”

Section: Discussionmentioning

confidence: 99%

Comparison of patients with hepatitis B virus‐associated hepatocellular carcinoma: Data from two hospitals from Turkey and China

Carr,

Rui,

Ince

et al. 2023

Portal Hypertension & Cirrhosis

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AimsThere are many studies on the incidence of hepatitis B virus (HBV)‐associated hepatocellular carcinoma (HCC), but very little is known about the HCC features in different populations. The study aimed to compare characteristics in two cohorts of patients with HBV‐associated hepatocellular carcinoma from Turkey and China.MethodsData on patients with HBV‐associated HCC diagnosed by imaging or liver biopsy were retrospectively collected from Shandong Provincial Hospital (n = 578) and Inonu University Hospital (n = 359) between January 2002 and December 2020, and the liver function and HCC characteristics were compared. Continuous variables were compared using Student's t‐test or Mann–Whitney U test and categorical variables were compared using the χ² test or Fisher's exact test.ResultsThe patients in the Turkish cohort had significantly worse Child‐Pugh scores (Child‐Pugh A: 38.3% vs. 87.9%; Child‐Pugh B: 40.3% vs. 11.1%; Child‐Pugh C: 21.4% vs. 1.0%; p < 0.001) and significantly higher levels of aspartate aminotransferase (66.5 [38.0−126.0] vs. 36.0 [27.0−50.0] IU/L; p < 0.001), alanine aminotransferase (47.5 [30.0−87.3] vs. 33.0 [24.0−45.0] IU/L; p < 0.001), total bilirubin (20.8 [13.7−39.3] vs. 17.9 [13.8−24.0] mg/dL; p < 0.001), and lower albumin levels (32.0 [26.0−39.0] vs. 40.0 [36.1−43.8] g/L; p < 0.001) than patients in Chinese cohort. The tumor characteristics showed the Barcelona Clinic Liver Cancer (BCLC) score (BCLC 1: 5.1% vs. 71.8%; BCLC 2: 48.7% vs. 24.4%; BCLC 3: 24.4% vs. 3.8%; BCLC 4: 21.8% vs. 0; all p < 0.001), maximum tumor diameter (5.0 [3.0−9.0] vs. 3.5 [2.5−6.0] cm; p < 0.001), alpha‐fetoprotein values (27.7 vs. 13.2 ng/mL; p < 0.001), and percentage of patients with portal vein tumor thrombus (33% vs. 6.1%; p < 0.001) were all significantly worse in the Turkish cohort compared with Chinese cohort.ConclusionsHBV‐associated HCC from the Turkish cohort had worse liver function and more aggressive clinical characteristics than patients from the Chinese cohort.

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Section: Discussionmentioning

confidence: 99%

Comparison of patients with hepatitis B virus‐associated hepatocellular carcinoma: Data from two hospitals from Turkey and China

Carr,

Rui,

Ince

et al. 2023

Portal Hypertension & Cirrhosis

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“…This can be attributed to factors such as political instability and inadequate healthcare infrastructure that have disrupted effective vaccination campaigns in some of these regions. 7 Given the potential challenges in gathering precise epidemiological data, the assessment of HBV prevalence among blood donors has emerged as an attractive approach in these areas due to the considerable number of individuals involved. 8 A comprehensive review study conducted in 2016 yielded valuable insights into the prevalence of HBV among blood donors across the Middle East.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Hepatitis B in Saudi Arabia from 2006 to 2021

Alghamdi,

Alghamdi

et al. 2023

HMER

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Background: This study describes the epidemiological pattern of acute hepatitis B virus (HBV) infection in Saudi Arabia from 2006 to 2021. It explores case frequency and the crude incidence rate (CIR) by year of diagnosis, age group, region, gender, and nationality of patients. Methods: Retrospective data on acute hepatitis B cases diagnosed across 20 regions of Saudi Arabia during January 2006 to December 2021 were obtained from the Saudi Ministry of Health's Statistical Yearbook. Statistical analyses were conducted using SPSS version 20.0, employing both parametric and non-parametric tests.

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“…In the WHO's Eastern Mediterranean Region, it is estimated that 60 million people are infected with HBV [2]. Several hepatitis prevalence studies were conducted in Middle Eastern countries including Jordan [3][4][5]. In Jordan estimated population of the Kingdom by Administrative Divisions at end-year of 2021 was reported to be eleven million fifty-seven thousand [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hepatitis B knowledge, practices, and beliefs among the Jordanian population: A cross-sectional study

et al. 2022

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This study aimed to assess the knowledge, practices, and beliefs among the Jordanian population regarding hepatitis B virus (HBV) infection. A cross-sectional questionnaire was designed and used to recruit participants from October 5th through December 12th. Statistical analysis was conducted using SPSS. Descriptive statistical analysis was used to analyse the sociodemographic data, the Shapiro-Wilk test was used to assess the normality, Cronbach’s α was used to evaluate the reliability of the questionnaire and Point-biserial correlation was used to figure out whether there is an association between Score of knowledge and the dichotomous variables. A random sample of 432 participated in the study. The majority were females (n = 310, 71.8%), the mean age was 21 (42.0%) years,416 (96.3%) were urban inhabitants and most of them (n = 351, 81.3%) had bachelor’s degree. School/university (n = 280, 64.8%) were reported as a major source of information followed by TV/internet/social media 276 (63.9%). The total mean (± SD) of knowledge score regarding HBV infection symptoms, transmission modes and treatment was found 12.28 ± 3.2. Participants’ knowledge regarding symptoms including nausea, vomiting and loss of appetite was 73 (16.9%). More than 80% had good knowledge regarding the complications of HBV infection. Only 100 participant reported vaccination (23.1%) against the virus. Poor knowledge and low vaccination rate against HBV were found thus implementing comprehensive educational program for people highlighting the importance of vaccination against the virus is crucial.

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Epidemiology of Hepatitis B Virus in the Middle East

Cited by 3 publications

References 48 publications

Comparison of patients with hepatitis B virus‐associated hepatocellular carcinoma: Data from two hospitals from Turkey and China

Comparison of patients with hepatitis B virus‐associated hepatocellular carcinoma: Data from two hospitals from Turkey and China

Epidemiology of Hepatitis B in Saudi Arabia from 2006 to 2021

Evaluation of hepatitis B knowledge, practices, and beliefs among the Jordanian population: A cross-sectional study

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