Epidemiology of Helicobacter pylori: acquisition, transmission, population prevalence and disease-to-infection ratio

Feldman, Roger A.; Eccersley, A. J. P.; Hardie, J. M.

doi:10.1093/oxfordjournals.bmb.a011678

Cited by 84 publications

(61 citation statements)

References 86 publications

(32 reference statements)

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“…This study has found comparable prevalence of H.pylori infection among dyspeptic patients as previously reported in Africa 7,8,14,15 . As compared to other studies in Africa 6,16 the observed prevalence in the current study is lower and this could be explained by geographical variation as documented previously 17,18 . Moreover; the sensitivity of the method used may explain such a difference.…”

Section: Prevalence and Factors Associated With Hpylori Infectionscontrasting

confidence: 56%

Sero-prevalence and associated factors of <i>Helicobacter pylori</i> infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Jaka¹,

Mushi

Mirambo

et al. 2016

Afr H. Sci.

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Background: Prevalence of H.pylori infection varies greatly between populations in different countries. This study was conducted to determine the magnitude of H.pylori among adult patients with dyspepsia attending the gastroenterology unit at Bugando medical centre. Methods: A cross sectional study involving 202 dyspeptic patients was conducted between June and July 2014. A Standardized data collection tool was used to collect socio-demographic characteristics. H.pylori antibodies were detected using rapid immunochromatographic tests according to manufacturer's instructions. Results: The median age of study population was 42 (IQR: 33-54). Females 105 (51.9%) formed majority of the population studied. Of 202 participants; 119 (58.9%) were from rural areas. Seroprevalence of H.pylori infection was found to be 79/202 (39.1%, 95% CI: 32.3 -45.7). As the age increased the risk of having H.pylori infection also increased (OR: 1.02 95% CI: 1-1.04, P=0.02). On multivariate logistic regression analysis untreated drinking water was found to predict H.pylori seropositivity (OR: 2.33, CI: 1.09-4.96, p=0.028). Conclusion:The seroprevalence of H.pylori among dyspeptic patients is high in this setting. Therefore the community in Mwanza should be educated on the use of safe drinking water in order to minimize H. pylori infections.

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Section: Prevalence and Factors Associated With Hpylori Infectionscontrasting

confidence: 56%

Sero-prevalence and associated factors of <i>Helicobacter pylori</i> infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Jaka¹,

Mushi

Mirambo

et al. 2016

Afr H. Sci.

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“…Despite current understanding of the pathophysiology and virulence determinants of this important gastric pathogen, its mode of transmission and infectious dose remain uncertain [4]. Person-to-person spread is the most probable mode of transmission, as no environmental or zoonotic reservoirs have been established.…”

Section: Introductionmentioning

confidence: 99%

Quantitative culture of Helicobacter pylori from gastric juice: the potential for transmission

Young¹,

Akyön²,

Rampton

et al. 2000

Journal of Medical Microbiology

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“…Enzymelinked immunosorbent assay (ELISA) detects various classes of antibodies to H pylori, indicating current or past infection. Because H pylori infection is not known to spontaneously resolve, a positive serologic test suggests active infection in patients who have not undergone eradication therapy [22] . Although H pylori is not an invasive bacterium, it actively stimulates the immune system in its host by releasing lipopolysaccharides and immunogenic proteins.…”

Section: Discussionmentioning

confidence: 99%

Analysis of immune responses againstH pyloriin rabbits

Islam

Khalil²,

Ahsan³

et al. 2007

WJG

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AIM: To investigate the immunogenicity of H pylori proteins, to evaluate the production rate of anti H pylori IgG antibodies in relation to time and to demonstrate the fidelity of newly optimized in-house enzymelinked immunosorbent assay (ELISA) technique as an alternative for H pylori infection assay. METHODS:In the present study, 100 μg of formalinfixed H pylori whole cell antigens was injected into an experimental animal (New Zealand white female rabbit) intramuscularly on d 0, 16, 27 and 36. The first two doses were injected with adjuvants. On d 0, a serum sample was collected from the rabbit before immunization and this pre-immunized serum was used as a negative control for the whole study. To evaluate the immunogenic responses of the injected antigen, serum samples were collected from the rabbit at regular intervals up to d 42. The sera were analyzed using inhouse ELISA and Western blot techniques. RESULTS:The production of anti H pylori IgG antibodies in the rabbit in response to the injected antigen increased almost exponentially up to d 14 and after that it was maintained at the same level until the last day (d 42). By analyzing the immune profiles of immunized sera, 11 proteins were identified to be immunogenic, among them 2 (approximately 100 kDa and 85 kDa) were most prominent. CONCLUSION:Analysis of the immune responses against pathogenic microorganisms like H pylori is necessary for the development of various diagnostic and preventive approaches. The results of this experiment reveal that the formalin-fixed H pylori whole cell antigens injected into the rabbit are highly immunogenic. These prominent proteins (approximately 100 kDa and 85 kDa) might have higher immunogenic effects among humans infected with H pylori and some of these immunogenic proteins can be included in diagnostic approaches based on serology and also for vaccine formulation. The inhouse ELISA is a promising alternative compared to invasive techniques.

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Epidemiology of Helicobacter pylori: acquisition, transmission, population prevalence and disease-to-infection ratio

Cited by 84 publications

References 86 publications

Sero-prevalence and associated factors of <i>Helicobacter pylori</i> infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Sero-prevalence and associated factors of <i>Helicobacter pylori</i> infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Quantitative culture of Helicobacter pylori from gastric juice: the potential for transmission

Analysis of immune responses againstH pyloriin rabbits

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