Epidemiology of Frequently Occurring Skin Diseases in Italian Children from 2006 to 2012: A Retrospective, Population‐Based Study

Cantarutti, Anna; Donà, Daniele; Visentin, Federica; Borgia, Eleonora; Scamarcia, Antonio; Cantarutti, Luigi; Peruzzi, Elena; Egan, Colin Gerard; Villa, Marco; Giaquinto, Carlo

doi:10.1111/pde.12568

Cited by 47 publications

(49 citation statements)

References 22 publications

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“…The frequency of CSU in cSLE is within the expected range reported in other populations of children and adolescents (0.1-3%) [31,33] . There are, however, no systematic studies regarding the prevalence of CSU in the Brazilian pediatric population.…”

Section: Discussionsupporting

confidence: 54%

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Ferriani

Silva

Pereira

et al. 2015

Int Arch Allergy Immunol

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Background: Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives of this study were to assess CSU in a large cSLE population, in order to evaluate the demographic data, clinical manifestations, disease activity/damage, laboratory abnormalities and treatment. Methods: A retrospective multicenter cohort study (Brazilian cSLE group) was performed in 10 Pediatric Rheumatology services and included 852 cSLE patients. CSU was diagnosed according to the guidelines of the European Academy of Allergy and Clinical Immunology, the Global Allergy and Asthma European Network, the European Dermatology Forum and the World Allergy Organization. Patients with CSU (evaluated at urticaria diagnosis) and patients without CSU (evaluated at the last visit) were assessed for lupus clinical/laboratory features and treatment. Results: CSU was observed in 10/852 cSLE patients (1.17%). The median of cSLE duration at urticaria diagnosis was 0 (-3 to 5) years. Comparison of cSLE patients with and without CSU revealed a greater frequency of constitutional symptoms (40 vs. 8%, p = 0.006), reticuloendothelial system involvement (30 vs. 3%, p = 0.003), mucocutaneous (90 vs. 28%, p < 0.0001) and musculoskeletal manifestations (50 vs. 6%, p < 0.0001) and methylprednisolone pulse therapy use (60 vs. 9%, p < 0.0001) in the former group. The frequency of immunosuppressive treatment was lower in patients with CSU (p = 0.018). The median SLE Disease Activity Index 2000 (12 vs. 2, p < 0.0001) and erythrocyte sedimentation rate (40 vs. 19 mm/1st hour, p = 0.024), was higher in patients with CSU. Conclusions: To our knowledge, this is the first study with evidence that CSU may be linked to cSLE. We also demonstrated that this particular skin manifestation occurs predominantly at disease onset and is associated with lupus moderate/high disease activity without major organ involvement.

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Section: Discussionsupporting

confidence: 54%

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Ferriani

Silva

Pereira

et al. 2015

Int Arch Allergy Immunol

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“…We have to point out that Italian prevalence of atopic eczema is lower than those reported in Northern countries. 42 Another interesting point is the higher prevalence of smokers in cases vs. controls (36.4% in T1 vs. 20% respectively) that was already reported in other studies 43 and probably related to the inflammatory effects of smoking that causes cytokines release and oxidative stress. Association between smoking and hand eczema was stronger in workers with hand eczema.…”

Section: Discussionmentioning

confidence: 70%

“…Much more actions on primary prevention must be done in Italy to discourage people with severe disease to start jobs at high risk for hand eczema. We have to point out that Italian prevalence of atopic eczema is lower than those reported in Northern countries …”

Section: Discussionmentioning

confidence: 74%

Effectiveness of a secondary prevention protocol for occupational contact dermatitis

Mauro

Giusti

Bovenzi

et al. 2016

Acad Dermatol Venereol

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“…Four studies 23 balanced and the size of the individual boxes for each study in the forest plots is therefore not substantially different.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta‐analysis

Fricke

Ávila-Valle

Keller

et al. 2019

Allergy

262

190

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Background and objectives Urticaria is a frequent skin condition, but reliable prevalence estimates from population studies particularly of the chronic form are scarce. The objective of this study was to systematically evaluate and summarize the prevalence of chronic urticaria by evaluating population‐based studies worldwide. Methods We performed a systematic search in PUBMED and EMBASE for population‐based studies of cross‐sectional or cohort design and studies based on health insurance/system databases. Risk of bias was assessed using a specific tool for prevalence studies. For meta‐analysis, we used a random effects model. Results Eighteen studies were included in the systematic evaluation and 11 in the meta‐analysis including data from over 86 000 000 participants. Risk of bias was mainly moderate, whereas the statistical heterogeneity (I2) between the studies was high. Asian studies combined showed a higher point prevalence of chronic urticaria (1.4%, 95%‐CI 0.5‐2.9) than those from Europe (0.5%, 0.2‐1.0) and Northern American (0.1%, 0.1‐0.1). Women were slightly more affected than men, whereas in children < 15 years we did not find a sex‐specific difference in the prevalence. The four studies that examined time trends indicated an increasing prevalence of chronic urticaria over time. Conclusions On a global level, the prevalence of chronic urticaria showed considerable regional differences. There is a need to obtain more sex‐specific population‐based and standardized international data particularly for children and adolescents, different chronic urticaria subtypes and potential risk and protective factors.

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Epidemiology of Frequently Occurring Skin Diseases in Italian Children from 2006 to 2012: A Retrospective, Population‐Based Study

Abstract: This study provides comprehensive evidence of the increasing prevalence and incidence of PSDs across Italy. Additional causality studies to address this important clinical and psychosocial problem are recommended.

Cited by 47 publications

References 22 publications

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Effectiveness of a secondary prevention protocol for occupational contact dermatitis

Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta‐analysis

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