Epidemiology of Escherichia Coli K1 in Healthy and Diseased Newborns

Sarff, LarrieD; McCracken, G. H.; Schiffer, MarkS; Glode, MaryP; Robbins, J B; Ørskov, Ida; Ørskov, Frits

doi:10.1016/s0140-6736(75)92496-4

Cited by 290 publications

(216 citation statements)

References 22 publications

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“…Similar high frequencies of K 1-carrying strains have been found in Europe Mulder, van Alphen & Zanen, 1984). K1 strains are found frequently but with lower frequencies in faeces of infants and adults (Robbins et al 1974a;Sarff et al 1975;0rskov & Orskov, 1975). The most frequent 0 groups associated with K 1 among American strains were 07, 018, 01 and 06 (Robbins et al 1974a;McCracken et al 1974), and the same 0 groups are found in European strains from neonatal meningitis.…”

Section: Role Of Adhesion For Experimental Infectionsupporting

confidence: 57%

“…NEONATAL MENINGITIS: 0 AND K ANTIGEN E. coli is a major cause of neonatal meningitis, and E. coli meningitis has a high mortality rate and frequency of sequelae (Robbins et al 1974a;. Robbins et al (1974a), McCracken et al (1974) and Sarff et al (1975) showed that 840% of E. coli isolated all over the U.S.A. from patients with this disease carried the K 1 antigen. Similar high frequencies of K 1-carrying strains have been found in Europe Mulder, van Alphen & Zanen, 1984).…”

Section: Role Of Adhesion For Experimental Infectionmentioning

confidence: 99%

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Escherichia coliin extra-intestinal infections

Ørskov

1985

J. Hyg.

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220

161

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When Theodor Escherich (1885a, b) first describedEscherichia colihe looked on it as a saprophytic organism. Soon several investigators found that colibacteria could be isolated from intestinal infections and from many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicaemia, pulmonary infections, and many more. Uhlenhuth (1897) showed that coli strains from pathological processes were more pathogenic in animal experiments than strains isolated from the normal intestine. Smith (1927), who examined strains from white scours in calves, showed that spontaneous acapsular mutants could be obtained from certain colibacteria, and that such mutants were less virulent when injected intra-peritoneally into guinea-pigs.

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Section: Role Of Adhesion For Experimental Infectionsupporting

confidence: 57%

Section: Role Of Adhesion For Experimental Infectionmentioning

confidence: 99%

Escherichia coliin extra-intestinal infections

Ørskov

1985

J. Hyg.

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220

161

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“…Predisposition to E. coli NBM is critically dependent on vertical transmission of the causative agent from mother to infant at or soon after birth 11 . Maternally-derived E. coli K1 bacteria colonize the neonatal gastrointestinal (GI) tract [11][12][13] , which is sterile at birth but rapidly acquires a complex microbiota 14 . In colonized neonates, E. coli K1 bacteria have the capacity to translocate from the intestinal lumen into the systemic circulation before entering the CNS across the blood-brain or blood-cerebrospinal fluid barriers 9,15 .…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Model of Neuropathogenic <em>Escherichia coli</em> Infection in the Neonatal Rat

Dalgakiran

Witcomb

McCarthy

et al. 2014

JoVE

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Investigation of the interactions between animal host and bacterial pathogen is only meaningful if the infection model employed replicates the principal features of the natural infection. This protocol describes procedures for the establishment and evaluation of systemic infection due to neuropathogenic Escherichia coli K1 in the neonatal rat. Colonization of the gastrointestinal tract leads to dissemination of the pathogen along the gut-lymph-blood-brain course of infection and the model displays strong age dependency. A strain of E. coli O18:K1 with enhanced virulence for the neonatal rat produces exceptionally high rates of colonization, translocation to the blood compartment and invasion of the meninges following transit through the choroid plexus. As in the human host, penetration of the central nervous system is accompanied by local inflammation and an invariably lethal outcome. The model is of proven utility for studies of the mechanism of pathogenesis, for evaluation of therapeutic interventions and for assessment of bacterial virulence.

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“…After incubation at 37°C for 24 h, presence of a precipitation reaction zone surrounding the colonies indicated the presence of the K1 antigen. E. coli O7:KC1, E. coli O5:H4, A. hydrophila ATCC 7966 T , A. caviae ATCC 15468 T , and A. veronii biovar sobria ATCC 35624 T strains were used as controls (Sarff & McCraken 1975).…”

Section: Methodsmentioning

confidence: 99%

“…E. coli is serogically heterogeneous but has been classified based on its antigens, and specific serogroups can be associated with reproducible and certain clinical syndromes. These studies have been used to establish which strains are present in different countries (Sarff & McCraken 1975, Nataro & Kaper 1998. Although Aeromonas is associated with diseases in very young humans and in older inmunocompromised patients who often require antimicrobial therapy, reports about the susceptibility of these organisms to antimicrobial agents are limited in our country.…”

mentioning

confidence: 99%