Epidemiology of drug-induced liver injury in a University Hospital from Colombia: Updated RUCAM being used for prospective causality assessment

Cano-Paniagua, Alejandra; Amariles, Pedro; Angulo, Nancy; Restrepo-Garay, Margarita

doi:10.1016/j.aohep.2018.11.008

Cited by 21 publications

(23 citation statements)

References 41 publications

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“…In the current analysis, authors from 31 countries worldwide reported on cases of idiosyncratic DILI caused by multiple drugs published from 1993 up to mid 2020 and applied in all cases RUCAM to assess causality ( Table 1 ) [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , …”

Section: Worldwide Publications Of Rucam Based Idiosyncratic Dilimentioning

confidence: 99%

Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis

Teschke

Danan²

2020

Medicines

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Background: A large number of idiosyncratic drug induced liver injury (iDILI) and herb induced liver injury(HILI) cases of variable quality has been published but some are a matter of concern if the cases were not evaluated for causality using a robust causality assessment method (CAM) such as RUCAM (Roussel Uclaf Causality Assessment Method) as diagnostiinjuryc algorithm. The purpose of this analysis was to evaluate the worldwide use of RUCAM in iDILI and HILI cases. Methods: The PubMed database (1993–30 June 2020) was searched for articles by using the following key terms: Roussel Uclaf Causality Assessment Method; RUCAM; Idiosyncratic drug induced liver injury; iDILI; Herb induced liver injury; HILI. Results: Considering reports published worldwide since 1993, our analysis showed the use of RUCAM for causality assessment in 95,885 cases of liver injury including 81,856 cases of idiosyncratic DILI and 14,029 cases of HILI. Among the top countries providing RUCAM based DILI cases were, in decreasing order, China, the US, Germany, Korea, and Italy, with China, Korea, Germany, India, and the US as the top countries for HILI. Conclusion: Since 1993 RUCAM is certainly the most widely used method to assess causality in IDILI and HILI. This should encourage practitioner, experts, and regulatory agencies to use it in order to reinforce their diagnosis and to take sound decisions.

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Section: Worldwide Publications Of Rucam Based Idiosyncratic Dilimentioning

confidence: 99%

Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis

Teschke

Danan²

2020

Medicines

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“…The true incidence of DILI is difficult to determine due to its lack of standardized diagnostic criteria, delay in diagnosis and unpredictable nature, but the population incidence is likely on the rise. DILI represents a serious clinical problem and potentially fatal course (Hayashi & Chalasani, 2015;Cano-Paniagua et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing

Zhang

Wang

Shen

et al. 2020

PeerJ

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Background Anthracycline-induced liver injury (AILI) is one of the serious complications of anthracycline-based adjuvant chemotherapy for postoperative breast cancer patients. Exosomal miRNAs, as signaling molecules in intercellular communication, play the essential roles in drug-induced liver injury (DILI). However, the expression profiles of them in patients with AILI remains unknown. Methods Seven post-chemotherapy patients were recruited in this study. After isolated plasma-derived exosomes, small RNA sequencing revealed exosomal miRNA profiles and differentially expressed miRNAs (DE-miRNAs) were identified between the liver injury group and non-liver injury group. miRTarBase and miRDB were used to predict the potential target genes of DE-miRNAs. DILI-related genes were downloaded from the CTD Database. The intersection of predicted genes and DILI-related genes were identified as the AILI-related target genes of the DE-miRNAs. GO annotation and KEGG pathway enrichment analysis were performed by the DAVID database. Furthermore, the protein-protein interaction (PPI) network was established by the STRING database and essential exosomal miRNAs were identified via Cytoscape software. Results A total of 30 DE-miRNAs and 79 AILI-related target genes were identified. AILI-related target genes of the DE-miRNAs are significantly enriched in NOD-like receptor signaling pathway, the HIF-1 signaling pathway, and the FoxO signaling pathway. Then, the hub genes were screened and we discovered that IL-6 and SOD2 are the most critical genes that may be involved in the development of AILI through the activation of immune response and the occurrence of oxidative stress, respectively. In addition, we found that miR-1-3p could potentially regulate most of the hub genes in the miRNA-hub gene network. Conclusion We explored the potential functions of DE-miRNAs and suggested exosomal miR-1-3p might be the essential exosomal miRNA in the pathogenesis of AILI. Moreover, our study provided an experimental basis for experimental verification to reveal the actual function and mechanism of miRNAs in AILI.

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“…Quanto aos critérios utilizados para a caracterização da DILI (Tabela 2), observamos que não houve concenso, apesar de que todos os artigos consideraram o valor da enzima hepática alanina aminotransferase (ALT que vem do inglês alanine aminotransferase) elevado. Sete artigos (Meier et al, 2005;Xu et al, 2012;Woo et al, 2015;Fang et al, 2018;Cano-Paniagua et al, 2019;Worland et al, 2020) utilizaram o algorítmo de causalidade de RUCAM…”

Section: Relato De Casounclassified

“…Entre os relatos de medicamentos encontrados, associados a DILI (Tabela 3), os de ocorrência mais frequente, de acordo com a classificação ATC, foram: 85% (23) na classe J, 37% (10) na classe M, 33,3% (9) na classe N, e 33,3% (9) na classe C. Encontrou-se também, em menor número, relatos de ocorrência de DILI com medicamentos antineoplásicos (Grupo L), antitrombóticos (Grupo B) e que atuam no trato alimentar e metabolismo (Grupo A). BAGHERI, H. et al, 2000.;MONTERO, A. R. et al, 2005;XU, H.M. et al, 2012;LEE, T. et al, 2013;DOUROS, A. et al, WOO, H. J. et al, 2015;2015;EL KAHI, C. et al, 2018;FANG, W. C. et al, 2018;CANO-PANIAGUA, A. et al, BAGHERI, H. et al, 2000;MONTERO, A. R. et al, 2005;XU, H. M.et al, 2012;DOUROS, A. et al, 2015;WOO, H. J. et al, 2015;ISA, S. E. et al, 2016;SALOOJEE, A. et al, 2017;FANG, W. C. et al, 2018;WORLAND, T. et H. et al, 2000;MEIER, Y. at al., 2005;EL KAHI, C. et al, 2018; BAGHERI, H. et al, 2000;MONTERO, A. R. et al, 2005;XU, H. M. et al, 2012;DOUROS, A. et al, 2015;FANG, W. C. et al, 2018 5 Fonte: Gonçalves, et al (2021).…”

Section: Relato De Casounclassified

Injúria Hepática Induzida por Medicamentos em Pacientes Hospitalizados

Gonçalves

Louro

Pedroso

et al. 2021

RSD

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Objetivo: Realizar uma revisão da literatura para identificar quais os medicamentos que mais causam injúria hepática induzida por medicamentos (DILI – que vem do inglês Drug Induced Liver Injury) em pacientes hospitlalizados. Metodologia: Foi realizada uma revisão da literatura por meio de busca sistemática de artigos sobre DILI em pacientes hospitalizados. Esta pesquisa seguiu a recomendação PRISMA-P (Principais Itens para Relatar Revisões Sistemáticas e Meta- Análises) e foram pesquisadas as seguintes bases de dados eletrônicas: PubMed, Web of Science, Scopus e Lilacs. Resultados: Inicialmente foi identificado um total de 454 artigos e após revisão do texto completo, foram selecionados 27 artigos. Todos os artigos selecionados consideraram o valor da enzima hepática alanina aminotransferase elevado para a caracterização da DILI. Foi identificado relatos de uma grande variedade de medicamentos, como prováveis causas de DILI, em pacientes hospitalizados. Conclusão: Os relatos de medicamentos associados a DILI, de acordo com a classificação ATC, foram: 85% (23) de fármacos do grupo J, 37% (10) do grupo M, 33,3% (9) do grupo N, e 33,3% (9) do grupo C. O grupo J, que abrange fármacos anti-infecciosos, foi o que teve maior número de relatos, sendo 47,8% (11) de antibióticos, 47,8% (11) de antituberculostáticos e 34,7 % (8) de antifúngicos. Destes, destacaram -se os Beta-lactâmicos, em especial a Amoxacilina-Clavulanto, Rifampicina, Isoniazida, Pirazinamida e Fluconazol.

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Epidemiology of drug-induced liver injury in a University Hospital from Colombia: Updated RUCAM being used for prospective causality assessment

Cited by 21 publications

References 41 publications

Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis

Worldwide Use of RUCAM for Causality Assessment in 81,856 Idiosyncratic DILI and 14,029 HILI Cases Published 1993–Mid 2020: A Comprehensive Analysis

Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing

Injúria Hepática Induzida por Medicamentos em Pacientes Hospitalizados

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