Epidemiology of classic Kaposi's sarcoma in the Israeli Jewish population between 1960 and 1998

Guttman‐Yassky, Emma; Barchana, Micha; Yukelson, A.; Linn, Shai; Friedman‐Birnbaum, Rachel; Bergman, Reuven; Sarid, Ronit; Silbermann, Michael

doi:10.1038/sj.bjc.6601313

Cited by 28 publications

(25 citation statements)

References 20 publications

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“…64 In Israel, rates of classic KS of 2.07 in men and 0.75 in women per 100,000 were calculated. 105 Interestingly, the highest rates were in men of North African lineage, correlating with high levels of antieHHV-8 antibodies. Amazingly, the HHV-8 infection rate among elderly New York City residents showed a seroprevalence of 8.6%, similar among religious groups and not differing by sex or regions of birth.…”

Section: Classic Ksmentioning

confidence: 99%

Kaposi sarcoma: A continuing conundrum

Schwartz

Micali

Nasca

et al. 2008

Journal of the American Academy of Dermatology

202

212

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Section: Classic Ksmentioning

confidence: 99%

Kaposi sarcoma: A continuing conundrum

Schwartz

Micali

Nasca

et al. 2008

Journal of the American Academy of Dermatology

202

212

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“…The regions with the highest incidence are Africa, where KS represents 3% to 9% of all cancer cases [31], Mediterranean and Eastern European areas, with specific geographic foci in Italy, Greece, and Israel [4,5]. …”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran

Jalilvand

Shoja

Mokhtari‐Azad

et al. 2011

Infect Agents Cancer

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Seroepidemiological surveys show that the prevalence of human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects the local incidence of classic and endemic KS, being widespread in sub-Saharan Africa and Mediterranean countries and uncommon in the USA and Northern Europe. In the Middle East only few populations, such as Ashkenazi and Sephardic groups in Israel, have been adequately evaluated for HHV-8 seroprevalence. Among Iranian population a striking higher seroprevalence of HHV8 has been reported among haemodialysis (16.9%), renal transplant recipients (25%) and HIV (45.7%) patients compared to blood donors (2%). Kaposi's sarcoma (KS) is the rarest cancer in Iran, with an annual age-standardized incidence varying from 0.10 to 0.17 per 100,000 in males and from 0.06 to 0.08 per 100,000 in females. KS, however, is one of the most important malignancies in Iranian renal transplanted patients affecting up to 2.4% of organ recipients. The epidemiology of HHV8 and KS in Iran needs further evaluation. While the high prevalence of HHV-8 antibodies in HIV positive and haemodialysis individuals may be attributed to high-risk sexual behavior and polytransfusions, respectively, unknown determinants may be responsible for high seroprevalence of HHV8 and high incidence of KS in solid organ recipients. A global survey on HHV8 seroprevalence in Iran is mandatory to define co-factors associated with HHV8 infection and KS risk in the general Iranian population and in specific patient groups.

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“…This study found a relatively higher incidence rate among the immigrants from Europe and North America as compared with the general population. However, in Israel, the prevalence of HHV-8 infection [16] and the incidence rate of KS [17] are elevated among immigrants from Morocco and lower among immigrants from North America and Europe. Moreover, IPAH incidence rates in Israel are similar to those reported in the United States and in Europe, while KS incidence rates and HHV-8 prevalence are relatively higher in Israel [18].…”

Section: Discussionmentioning

confidence: 99%

Absence of Human Herpesvirus 8 DNA Sequences in Lung Biopsies from Israeli Patients with Pulmonary Arterial Hypertension

et al. 2006

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Background:Pulmonary hypertension is a severe pulmonary vascular disease leading to rapid deterioration and death. Histological and clinical evidence suggests that smooth muscle proliferation is part of the pathogenesis of the disease. Human herpesvirus 8 (HHV-8) is a γ-herpesvirus that is implicated in malignancies and in Kaposi’s sarcoma. Recently, the association of HHV-8 with idiopathic pulmonary arterial hypertension (PAH) has been found. Objective: The aim of this study was to investigate the presence of HHV-8 in the lung tissue of Israeli patients with PAH. Method: The presence of HHV-8 sequences was investigated by polymerase chain reaction examination in 6 biopsies of patients with pulmonary hypertension. Three patients had idiopathic pulmonary hypertension, 2 patients pulmonary venoocclusive disease, and 1 patient pulmonary hypertension associated with mixed connective tissue disease. Result: We did not find any association between HHV-8 and PAH in these Israeli patients, as all the samples were negative for polymerase chain reaction. Conclusion: Our findings, together with the epidemiological data of HHV-8 prevalence and incidence rates of Kaposi’s sarcoma and PAH in Israel, provide further evidence which argues against an association between HHV-8 infection and PAH.

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Epidemiology of classic Kaposi's sarcoma in the Israeli Jewish population between 1960 and 1998

Cited by 28 publications

References 20 publications

Kaposi sarcoma: A continuing conundrum

Kaposi sarcoma: A continuing conundrum

Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran

Absence of Human Herpesvirus 8 DNA Sequences in Lung Biopsies from Israeli Patients with Pulmonary Arterial Hypertension

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