Epidemiology of breast cancer in women based on diagnosis data from oncologists and senologists in Algeria

Smaili, F.; Boudjella, Abdelkader El Hakim; Dib, Adlane; Braikia, S; Zidane, Habib; Reggad, R; Bendib, A.; Abdelouahab, A; Bereksi-Reguig, F.; Yekrou, D.; Bentouati, A; Filali, T.; Chirouf, A.; Djehal, Nardjes; Mahfouf, Hassen; Mechiat, F; Tadjerouni, H; Sedkaoui, C.; Hikem, M; Amber, A; Bouzid, K.; Ladjeroud, Amel; Ghomari, S; Aris, H; Saidi, S.; Larhbali, R; Saidi, MA; Haddouche, Amal; Kedar, M; Bounedjar, A.; Talha, Sheikh M.; Benbrahim, Wassila; Ammari, Amer; A, Boushaba; Rabah, Ali A.; Ameziane, Najim; Benabdallah, F; Djedi, H.; Kouadri, N; Bensalem, A.; Djeghim, S; Oukkal, Mohammed; Hadjam, Farida; Larbaoui, B.; Rekai, K.; Azzouz, Nassim; Badaoui, Abdenor; Abid, Muhammad Bilal; Abada, M.; Moussei, A.; Benmehidi, F; Benzidane, N; Boualga, K.; Mesli, Samy

doi:10.1016/j.ctarc.2020.100220

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Breast cancer is the most common type of cancer among women worldwide. It is estimated that ~1.4 million women are diagnosed with breast cancer every year, and 458,000 women succumb to the disease, making it the second most frequently diagnosed type of cancer worldwide ( 1 ). The incidence of early-onset breast cancer in America is 10.3% of all new female breast cancer cases in 2012–2016 and has markedly increased among young women aged 18–45 years ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A

et al. 2022

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Breast cancer is one of the most common malignant tumors in women. Cell division cycle-associated 5 (CDCA5) is closely associated with the behavior of various cancer types. The aim of the present study was to explore the effect of CDCA5 on breast cancer. Western blot analysis and reverse transcription-quantitative PCR were used to detect the expression level of CDCA5 in human normal mammary cells and human breast cancer cell lines. To determine its function in MDA-MB-231 cells, CDCA5 was silenced in MDA-MB-231 cells by transient short hairpin RNA transfection. Cell Counting Kit-8 and clonogenicity assays were used to evaluate cell proliferation. Wound healing and Transwell assays were used to detect cell invasion and migration. Western blot analysis was used to detect the protein expressions of Ki67 and PCNA associated with proliferation, MMP2 and MMP9 associated with migration. CDCA5 was found to be markedly increased in breast cancer cell lines. CDCA5 knockdown was able to suppress cell proliferation, invasion and migration. CDCA5 inhibition downregulated PDS5 cohesin-associated factor A (PDS5A) expression in breast cancer cells. PDS5A overexpression was found to reverse the effect of CDCA5 inhibition on breast cancer cell proliferation and migration. CDCA5 knockdown was shown to suppress the malignant progression of breast cancer cells by regulating PDS5A. The present findings may provide new potential targets for breast cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A

et al. 2022

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“…Breast cancer in Ethiopia has consistently been shown to be associated with advanced stage at diagnosis [ 4 , 7 , 11 ]. Concordant reports have been published from other low-income countries [ 12 – 14 ]. Even in a study like ours where only patients with loco-regional disease were included, the proportion of early local stage like stage I is still extremely small.…”

Section: Discussionmentioning

confidence: 61%

Experience with modified radical mastectomy in a low-income country: a multi-center prospective observational study

et al. 2021

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Background Modified radical mastectomy is the procedure of choice in centers with little to no radiotherapy services. Studying the in-hospital outcome and complications associated with the procedure is important in low-income countries. Methods This is a multi-center prospective observational study involving all patients operated with modified radical mastectomy with curative intent. Results A total of 87 patients were studied with 10.3% of which were male and 54% were between the age of 30–49 years. Clinical stage IIB and IIIA were reported in 33 (37.9%) and 25 (28.7%) respectively and 62.1% had clinically positive lymph nodes at presentation. All of the studied patients underwent curative surgery, with an average lymph node dissection of 10.2 ± 0.83. Seroma rate was 17.2% and was significantly associated with diabetes (AOR: 6.2 (CI 1.5–8.7)) and neoadjuvant chemotherapy (AOR: 8.9 (CI 1.2–14.2)). Surgical site infection occurred in 14.9% and was significantly associated with Retroviral infections (AOR: 4.2 (CI 2.1–5.8)) and neoadjuvant chemotherapy (AOR: 1.8 (CI 1.3–3.9)). No in-hospital mortality occurred during the course of the study. Conclusion Seroma rate was lower than published studies while surgical site infections rate was higher. Neoadjuvant chemotherapy was associated with increase in seroma and surgical site infection rates. Additionally, diabetes increased the rate of seroma. Surgical site infections were higher in patients with retroviral infections.

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“…Similarly, in previous Algerian studies, median age at diagnosis was 47 years. In another Algerian series, two peak incidences were described: One at the fifth decade and the other in the age group of 70–74 years 25,26 . A comprehensive literature review of reports of BC in Arab countries reported a median age of 44.5 years 27 .…”

Section: Discussionmentioning

confidence: 98%

Pathologically confirmed women's breast cancer: A descriptive study of Tunisian and Algerian series

et al. 2023

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BackgroundBreast cancer (BC) is the most frequent malignancy among women in Tunisia and Algeria. Clinical and pathological characteristics of this cancer among these populations are not widely reported. The aim of the study was to report clinical and pathological characteristics of women's BC in a Tunisian and Algerian series.MethodsPathologically confirmed 1089 BCs were gathered in the pathology departments of three Northern Tunisian hospitals: Tunis military, Charles Nicolle and Jendouba and in the pathology department of Alger Douera hospital between January 2015 and December 2020. Clinical and pathological findings of the two series: age, tumor size, histological type, grading according to Scarff‐Bloom Richardson grading system, lymph node status at the time of diagnosis in axillary lymphadenectomy specimens and the immunohistochemical expression of estrogen and progesterone receptors (ER/PR), HER2 and Ki‐67, were collected from the pathological reports.ResultsThe median age at diagnosis was 50 and 48 years in Tunisian and Algerian series, respectively (p = 0.016). The diagnosis of BC was made on surgical specimens (lumpectomy or mastectomy) in 373/491 (76%) cases of the Tunisian series and in 225/598 (37.6%) cases of the Algerian one. Median tumor size was 2.8 cm and 2.5 cm in Algerian and Tunisian series, respectively (p = 0.252). Invasive BCs not otherwise specified was observed in 440/481 (91.5%) BCs in Tunisian series and in 519/586 (88.6%) BCs in Algerian series. Axillary lymph node positive tumors were observed in 64.6% and 58.8% of Tunisian and Algerian women, respectively (p = 0.926). BCs were ER positive in 311/385 (80.8%) and 486/571 (85.1%) cases and HER2 positive in 86/283 (30.4%) and 60/385 (15.6%) cases of Tunisian and Algerian series, respectively.ConclusionsIn Tunisia and Algeria, BC has poor prognostic factors with large tumor sizes and high rates of lymph nodes involvement at diagnosis.

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Epidemiology of breast cancer in women based on diagnosis data from oncologists and senologists in Algeria

Cited by 8 publications

References 7 publications

Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A

Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A

Experience with modified radical mastectomy in a low-income country: a multi-center prospective observational study

Pathologically confirmed women's breast cancer: A descriptive study of Tunisian and Algerian series

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