Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990–2010: a systematic review and analysis

Chan, Kit Yee; Wu, Jing; Liu, Li; Τheodoratou, Evropi; Car, Josip; Middleton, Lefkos T.; Russ, Tom C.; Deary, Ian J.; Campbell, Harry; Wang, Wei; Rudan, Igor

doi:10.1016/s0140-6736(13)60221-4

Cited by 591 publications

(486 citation statements)

References 36 publications

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“…Recent studies suggest that changes have been occurring, with decreases in the agespecific incidence or prevalence in the United States, United Kingdom, Sweden, the Netherlands, France, and Canada, probably reflecting reduced exposure to risk factors or increased resilience to cognitive decline, but in others, for example, Japan and China this is not the case (Chan et al 2013;Okamura et al 2013). Identifying and modifying risk could translate to a huge benefit for societies, individuals, and health care systems.…”

Section: Prevention Of Dementia Recommendationsmentioning

confidence: 99%

The Lancet Commission on Dementia Prevention, Intervention, and Care: a call for action

Orgeta

Mukadam

Sommerlad

et al. 2018

Ir. j. psychol. Med.

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The purpose of this Editorial is to summarise the key recommendations of the Lancet Commission on Dementia Prevention, Intervention, and Care, reporting on the best available evidence to date on what we can do to prevent and intervene for dementia. We briefly describe the new life-course model of dementia prevention incorporating nine modifiable risk factors and their potential effect in reducing individuals' risk of dementia. We also summarise the recommendations of the report about which pharmacological, psychological, and social interventions are effective, and improve outcomes for people with dementia and their families. Recent developments highlight that there is good potential for the prevention of dementia. Progress in evidence-based approaches indicate the potential for dementia care to be of high-quality and widely accessible. Acting upon this knowledge now will reduce the global burden of dementia and improve the lives of people living with dementia and their families.

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Section: Prevention Of Dementia Recommendationsmentioning

confidence: 99%

The Lancet Commission on Dementia Prevention, Intervention, and Care: a call for action

Orgeta

Mukadam

Sommerlad

et al. 2018

Ir. j. psychol. Med.

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“…Aging is a key issue in China nowadays, given the serious challenge posed by AD (19). AD has a similar level of prevalence in China, Japan, the US, and Europe (Table 1) (9,20-23).…”

Section: The Chinese Government Has Implemented a Clinical Pathway Fomentioning

confidence: 99%

“…In addition, three clinical trials are being prevalence rates are roughly the same in these countries, China accounts for the major share of AD prevalence worldwide because of China's huge population. Chan et al estimated that there were 5.69 million people with AD (3.85-7.53) in 2010 (19).…”

Section: Government Emphasis On Cooperation With Multiple Partners Inmentioning

confidence: 99%

The Government's role in regulating, coordinating, and standardizing the response to Alzheimer's disease: Anticipated international cooperation in the area of intractable and rare diseases

Tang

Song

2016

IRDR

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“…In 2010, 58% of all demented people lived in low-cost countries, with their proportion anticipated to rise to 71% in 2050 [22]. According to recent data from China the incidence of dementia was 9.87/1000 person years and the median standardised mortality ratio was 1.94:1 [23]. With the disproportional growth of the elderly population, dementia has become a major public health and socio-economic problem that threatens to become the scourge of our century.…”

Section: Introductionmentioning

confidence: 99%

Neuropathology of Dementia Disorders

Jellinger¹

2014

J Alzheimers Dis Parkinsonism

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IntroductionDementia, encompassing deficits in several cognitive domains that are severe enough to interfere with daily functioning [1], in the new DSM V classification is classified within the broad category of major neurocognitive disorders, proposing specific criteria for the various etiologies [2]. Previously defined as the manifestation of deteriorating brain functions over time due to cell deaths in the brain caused by neurodegeneration or any other disease [3], according to recent research dementia is not primarily caused by neuronal cell death/loss, but by dysfunction and loss of synapses [4] in AD [5] and in α-synucleinopathies [6]. Other causes include cholinergic neuronal and axonal abnormalities [7,8], as well as pre-and postsynaptic cortical cholinergic deficits also occurring in early AD [9]. These changes due to disconnection of major nervous circuitries causing default networks [10][11][12][13] have been demonstrated in vivo in early AD [14], suggesting that disease progress is transmitted by neuronal pathways [15]. A prionlike spread of misfolded protein aggregates in the pathogenesis and progression of neurodegeneration is a hot spot of discussion [16][17][18][19][20][21].Both the prevalence and incidence of dementia increase exponentially with age. In 2010, 35.6 million people worldwide lived with dementia, with around 8 million new cases every year. Numbers are expected to double or triple every 5-10 years, to 135 millions in 2050, 16 millions in Europe. In 2010, 58% of all demented people lived in low-cost countries, with their proportion anticipated to rise to 71% in 2050 [22]. According to recent data from China the incidence of dementia was 9.87/1000 person years and the median standardised mortality ratio was 1.94:1 [23]. With the disproportional growth of the elderly population, dementia has become a major public health and socio-economic problem that threatens to become the scourge of our century. The total costs for dementia were US$ 604 billion in 2010 worldwide, up to 70% for social care alone [24], total payments for AD for 2013 were expected to be $ 203 billion in USA alone, not included contributions of unpaid caregivers [25]. Neuropathology of Dementia DisordersKurt A Jellinger* Institute of Clinical Neurobiology, Kenyongasse 18, A 1070, Vienna, Austria AbstractDementia, being not a specific disease but a syndrome characterized by deficits in several cognitive domains, is a major public health and socio-economic problem of our century. It is caused by dysfunction/loss of synapses and neurons inducing default neuronal networks. Despite updated concensus criteria for the clinical diagnosis of the major neurodegenerative disorders and new biomarkers, the diagnostic accuracy ranges from 65 to 96% (for Alzheimer's disease /AD), with a sensitivity versus other dementias of around 85.4% and a specificity of up to 77.7%. Pathologic assessment, using genetic and molecular biological methods, based on homogenous definitions, harmonized interlaboratory and assessment standards, can achiev...

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Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990–2010: a systematic review and analysis

Cited by 591 publications

References 36 publications

The Lancet Commission on Dementia Prevention, Intervention, and Care: a call for action

The Lancet Commission on Dementia Prevention, Intervention, and Care: a call for action

The Government's role in regulating, coordinating, and standardizing the response to Alzheimer's disease: Anticipated international cooperation in the area of intractable and rare diseases

Neuropathology of Dementia Disorders

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