Epidemiology of acute otitis media among young children: A multiple database study in Taiwan

Ting, Pei Ju; Lin, Ching Heng; Huang, Fang; Lin, Ming Tsan; Hwang, Kao Pin; Huang, Yhu Chering; Chiu, Cheng Hsun; Lin, Tzou Yien; Chen, Po Yen

doi:10.1016/j.jmii.2012.06.007

Cited by 19 publications

(16 citation statements)

References 31 publications

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“…Overall, this study showed that the air quality was at a moderate pollution level in Lanzhou, which is similar with the research of Hu et al [14]. Meanwhile, we also found that there were more male ASOM patients than female ASOM patients, and male patients were 1.16 times as many as female patients, this is consistent with the literature report [15]. Which may be related to the higher incidence of acute respiratory infections in male patients, or to the sex ratio of infants born in China.…”

Section: Associations Between Air Pollutants and Meteorological Variasupporting

confidence: 92%

Analysis of the Association between environmental-meteorological factors and Acute Suppurative Otitis Media: Further Epidemiological Evidence from Lanzhou, Northwestern China

Wang¹,

Xu²,

Tian³

et al. 2020

Preprint

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Objective To investigate the possible associations, lag effects and pathogenic characteristics of urban air quality on acute suppurative otitis media (ASOM）in Lanzhou, a city in Northwestern China. Methods SPSS software was used to analyze Spearman correlation between ambient environment-meteorological factors and the daily number of patient ASOM visits. The GAM of time series was used to analyze the exposure -response curve, and R software was used to calculate RR.Using above results to discuss the relationship of air pollutions , meteorological factors and morbidity of ASOM. Results The number of patients with ASOM in 2014, 2015 and 2016 were 916, 875 and 1023 respectively. There was no significant difference in three years (P=0.85). The annual visits peaked in December, the lowest in August, followed by February, Summer was less than the other three seasons. The morbidity of ASOM had a largest peak within 14 years old (53.84%), and the number of male patients 1514 (53.6%) is 1.16 times that of female patients 1309 (46.4%). Spearman correlation analysis showed that the correlation between air pollutions and environmental variables. As for single-day lag effects , there were positive correlations between PM 2.5 , PM 10 , CO, NO 2 , SO 2 and the daily number of ASOM visits, but the correlation between O 3 and ASOM did not pass the significance test . As for multi-day lag effects, PM 2.5 , PM 10 , CO, NO 2 had lagging effects on the daily number of ASOM visits, but the correlation between SO 2 and O 3 did not pass the significant test. There was a positive correlation between ATM and the daily number of patient ASOM visits, and negative correlation between T and the daily number of patient ASOM visits ,while the correlation between W, RH and ASOM was weak. Conclusions The incidence of ASOM has obvious age and seasonal characteristics. There may be some correlation between environmental-meteorological factors and the incidence of ASOM. Therefore, it is of great significance to strengthen environmental control and public health strategy in order to reduce and prevent the occurrence of ASOM diseases.

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Section: Associations Between Air Pollutants and Meteorological Variasupporting

confidence: 92%

Analysis of the Association between environmental-meteorological factors and Acute Suppurative Otitis Media: Further Epidemiological Evidence from Lanzhou, Northwestern China

Wang¹,

Xu²,

Tian³

et al. 2020

Preprint

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“…Similarly, otorrhea, otalgia, tinnitus and itching were more prevalent in humid seasons than other ones. An unanticipated finding of this study was that there was no significant relationship between OM and season ( p =0.55) among children, while previous studies have reported a strong relationship (Ting, et al,17) Rovers, et al,28) Castagno and Lavinsky,15) and Salah, et al16)). This result may be due to the small number of children in the study.…”

Section: Discussioncontrasting

confidence: 65%

“…A retrospective study on 340 infants below 2 years old with recurrent acute otitis media (RAOM), conducted by Cairo University Hospital from May 2011 to April 2012 indicated that winter is an important factor that may cause RAOM 16). In 2012, Ting, et al,17) carried out a multiple database study in Taiwan and reported acute otitis media (AOM) as a prevalent OM among children in spring. A higher resolution rate in summer and a lower resolution rate in autumn were reported by Gordon, et al18) prospective study in New York.…”

Section: Introductionmentioning

confidence: 99%

Conductive and Mixed Hearing Losses: A Comparison between Summer and Autumn

Nickbakht

Borzoo

2014

Korean J Audiol

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Background and ObjectivesConductive hearing loss is common among children and adults. This study aims at comparing the results of conductive hearing loss in summer and autumn.Subjects and MethodsPuretone audiometry and tympanometry tests were done for all patients who referred to the Iranian-based audiology center of Imam Khomeini Hospital in Ahvaz. Data on the patients with conductive or mixed hearing loss were analyzed. The impacts of season, age, and etiology of the disease were analyzed on the patients who visited the audiology clinic due to the conductive hearing loss in summer and autumn.ResultsOne hundred and fifty nine patients in summer and 123 patients in autumn had conductive or mixed hearing loss. Their age ranged from four to 82 years, with the average age of 35. The percentage of the patients, with acute otitis media and chronic otitis media (COM), who visited this clinic, was significantly higher than those with middle ear problems. COM and mastoid surgeries rate was higher in summer than autumn among adults.ConclusionsThere is no relationship between season and middle ear diseases between children and juveniles, but COM and mastoid problems are more common in summer among adults visiting this clinic. Most of the patients had mild conductive hearing loss and bilateral middle ear impairments.

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“…Inflammatory response has been reported to be of great importance in otitis media formation. Otitis media is characterized by inflammation ( 6 ). The formation of otitis media, epithelial cells play a vital role in defending numorous stresses, including pro-inflammatory cytokine secretion ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media

Chen

2018

Int J Mol Med

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Otitis media is one of the most common bacterial infections in children, contributing to hearing loss. A vital bacterial pathogen leading to otitis media development is the nontypeable Haemophilus influenzae (NTHi). Inflammation response is reported as an important characristic for otitis media. Chemokine CXC receptor 4 (CXCR4) is a 352-amino acid seven-span transmembrane G-protein coupled receptor, essential for inflammatory response. However, the possible molecular mechanism indicating the alteration of CXCR4 modulated by NTHi is poorly known. In the present study, NTHi enhanced CXCR4 expression through phosphorylation of IKKα and p38, which relied on nuclear factor-κB (NF-κB) translocation in vitro as well as in the middle ear of mice in vivo. Previously, quercetin, a natural production mainly isolated from rutin, has shown anti-inflammatory effects. Here, we report that quercetin suppressed NTHi-induced CXCR4 expression levels in vitro and in vivo. Quercetin blocked CXCR4 activation through direct IKKβ phosphorylation inhibition, as well as of p38 MAPK restraining. Hence, identification of quercetin may be a potential therapeutic strategy for treating otitis media induced by NTHi through inflammation suppression.

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Epidemiology of acute otitis media among young children: A multiple database study in Taiwan

Cited by 19 publications

References 31 publications

Analysis of the Association between environmental-meteorological factors and Acute Suppurative Otitis Media: Further Epidemiological Evidence from Lanzhou, Northwestern China

Analysis of the Association between environmental-meteorological factors and Acute Suppurative Otitis Media: Further Epidemiological Evidence from Lanzhou, Northwestern China

Conductive and Mixed Hearing Losses: A Comparison between Summer and Autumn

Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media

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