Epidemiology of Acute Kidney Injury in Africa

Naicker, Saraladevi; Aboud, O.I.; Gharbi, Mohamed Benghanem

doi:10.1016/j.semnephrol.2008.04.003

Cited by 107 publications

(104 citation statements)

References 10 publications

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“…In reviewing the causes of AKI in the developing world, we find the high mortality rates may be due to AKI as a result of these diseases [5] . This is in stark contrast to AKI in the developed world, where trauma, industrial accidents, drugs, cardiogenic and septic shock, as well as renal transplant rejection are the more common causes [6] .…”

Section: Aimmentioning

confidence: 99%

Peritoneal Dialysis as a Mode of Treatment for Acute Kidney Injury in Sub-Saharan Africa

et al. 2013

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pital in Kumasi, Ghana, 28 patients have been treated with PD for AKI so far. Half of them were treated successfully and were discharged having fully recovered kidney function. Seven patients (25%) were determined to have end-stage renal disease, whereas 7 others (25%) died during hospitalization. In these cases, late presentation for dialysis may have contributed to the inability to recover. Conclusion: For individuals and governments alike, who are concerned about the cost of providing or paying for dialysis, using PD to treat AKI is an effective and simpler modality compared to HD and can be performed without the need for machinery or electricity, making it an ideal choice in a low-resource setting.

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Section: Aimmentioning

confidence: 99%

Peritoneal Dialysis as a Mode of Treatment for Acute Kidney Injury in Sub-Saharan Africa

et al. 2013

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“…[13] In rural areas it is proposed that AKI is usually community-acquired affecting younger and previously healthy individuals in which AKI is associated with diarrhoeal disease, infectious diseases, animal venoms, septic abortions, dyes and natural medicines. [14] Although there are a handful of studies describing the association between glomerular disease and CKD in Africa, [15][16][17] in contrast very little data exist on the nature of AKI. Specifically, to our knowledge, no studies have characterised glomerular disease in AKI in this geographical context.…”

Section: Discussionmentioning

confidence: 99%

Glomerular disease and acute kidney injury in Sudan: Demographics, histological diagnosis and outcome

El-hassan¹,

Ghalib

Ibrahim³

et al. 2016

S Afr Med J

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“…A large sample size was a criterion for study inclusion, which likely excluded reports of community-acquired AKI originating from developing countries, especially in children, that involved small numbers of patients. Although 85 % of the world's younger population lives in low-and middle-income countries (LMICs), systematic prospective studies from those regions are limited by problems with communication between centers and absence of mechanisms to collect accurate data [96,97,[101][102][103][104].…”

Section: Global Study On Aki-role Of International Organizationsmentioning

confidence: 99%

Epidemiology of acute kidney injury in children worldwide, including developing countries

2016

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In this review we summarize the world-wide epidemiology of acute kidney injury (AKI) in children with special emphasis on low-income countries, notably those of the sub-Saharan continent. We discuss definitions and classification systems used in pediatric AKI literature. At present, despite some shortcomings, traditional Pediatric Risk Injury Failure Loss and End Stage Kidney Disease (pRIFLE) and Kidney Disease Improving Global Outcomes (KDIGO) systems are the most clinically useful. Alternative definitions, such as monitoring serum cystatin or novel urinary biomarkers, including cell cycle inhibitors, require more long-term studies in heterogenous pediatric AKI populations before they can be recommended in routine clinical practice. A potentially interesting future application of some novel biomarkers could be incorporation into the "renal angina index", a concept recently introduced in pediatric nephrology. The most reliable epidemiological data on AKI in children come from high-outcome countries and are frequently focused on critically ill pediatric intensive care unit populations. In these patients AKI is often secondary to other systemic illnesses or their treatment. Based on a recent literature search performed within the framework of the "AKI 0by25" project of the International Society of Nephrology, we discuss the scarce and often inaccurate data on AKI epidemiology in low-income countries, notably those on the African continent. The last section reflects on some of the many barriers to improvement of overall health care in low-income populations. Although preventive strategies for AKI in low-income countries should essentially be the same as those in high-income countries, we believe any intervention for earlier detection and better treatment of AKI must address all health determinants, including educational, cultural, socio-economic and environmental factors, specific for these deprived areas.

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Epidemiology of Acute Kidney Injury in Africa

Cited by 107 publications

References 10 publications

Peritoneal Dialysis as a Mode of Treatment for Acute Kidney Injury in Sub-Saharan Africa

Peritoneal Dialysis as a Mode of Treatment for Acute Kidney Injury in Sub-Saharan Africa

Glomerular disease and acute kidney injury in Sudan: Demographics, histological diagnosis and outcome

Epidemiology of acute kidney injury in children worldwide, including developing countries

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