Glomerular disease and acute kidney injury in Sudan: Demographics, histological diagnosis and outcome

El-hassan, El-hussein E A; Ghalib, Mohamed; Ibrahim, Azam I S; Phillips, Bethan; Phillips, Aled Owain

doi:10.7196/samj.2016.v106i7.10392

Cited by 2 publications

(5 citation statements)

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“…The included studies have a combined sample size of 6,494 individuals from 8 African countries (Egypt, Morocco, Sudan, Ivory Coast, Gambia, Senegal, Kenya, and South Africa). There were 1,354 participants (9 studies) from North Africa [ 27 - 30 , 32 , 33 , 37 , 39 , 43 ], 1,584 (4 studies) from West Africa [ 34 , 35 , 40 , 41 ], 193 (1 study) from East Africa [ 36 ], and 3,363 (3 studies) from Southern Africa [ 31 , 38 , 42 ]. Ten of the studies [ 29 , 32 , 34 - 38 , 40 , 42 , 43 ] included only adults, five reported data only in paediatrics [ 28 , 30 , 31 , 33 , 39 ], while two studies reported adult and paediatric data [ 27 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…There were 1,354 participants (9 studies) from North Africa [ 27 - 30 , 32 , 33 , 37 , 39 , 43 ], 1,584 (4 studies) from West Africa [ 34 , 35 , 40 , 41 ], 193 (1 study) from East Africa [ 36 ], and 3,363 (3 studies) from Southern Africa [ 31 , 38 , 42 ]. Ten of the studies [ 29 , 32 , 34 - 38 , 40 , 42 , 43 ] included only adults, five reported data only in paediatrics [ 28 , 30 , 31 , 33 , 39 ], while two studies reported adult and paediatric data [ 27 , 41 ]. The average age of the patients ranged from 5.2 to 44.8 years.…”

Section: Resultsmentioning

confidence: 99%

“…Nephrotic syndrome (61.5% [IQR 47.7 - 100%]), abnormal kidney function (11.2% [IQR 0.0 - 16.6%]), and nephritic syndrome, 1.0% (IQR 0 - 6.7%) were the most prevalent indications for performing kidney biopsy. Eleven (64.7%) studies were of high quality [ 29 - 31 , 35 - 39 , 41 - 43 ], and 6 (35.3%) were of medium quality [ 27 , 28 , 32 - 34 , 40 ]. Method of histopathological assessment was not reported in 4 studies (23.5%) [ 33 , 34 , 40 , 44 ] 2 studies (11.8%) only used LM [ 28 , 36 ] 7 studies (41.2%) only used LM and IHC/IF [ 27 , 29 , 32 , 35 , 37 , 39 , 43 ], while 4 studies (23.5%) reported use of LM, IHC/IF, and EM [ 30 , 31 , 38 , 42 ] for reporting histologies.…”

Section: Resultsmentioning

confidence: 99%

“…Eleven (64.7%) studies were of high quality [ 29 - 31 , 35 - 39 , 41 - 43 ], and 6 (35.3%) were of medium quality [ 27 , 28 , 32 - 34 , 40 ]. Method of histopathological assessment was not reported in 4 studies (23.5%) [ 33 , 34 , 40 , 44 ] 2 studies (11.8%) only used LM [ 28 , 36 ] 7 studies (41.2%) only used LM and IHC/IF [ 27 , 29 , 32 , 35 , 37 , 39 , 43 ], while 4 studies (23.5%) reported use of LM, IHC/IF, and EM [ 30 , 31 , 38 , 42 ] for reporting histologies. High-quality studies were from East Africa (n=1) [ 36 ], Southern Africa (n=3) [ 31 , 38 , 42 ], West Africa (n=2) [ 35 , 41 ] and North Africa (n=5) [ 29 , 30 , 37 , 39 , 43 ] ( Table 1 , Table 1 (suite) .…”

Section: Resultsmentioning

confidence: 99%

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Prevalence and distribution of primary glomerular diseases in Africa: a systematic review and meta-analysis of observational studies

Ekrikpo,

Obiagwu,

Udo

et al. 2023

Pan Afr Med J

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Glomerulonephritis (GN) is a predominant cause of kidney failure in Africa. The prevalence of primary GNs varies widely across Africa depending on the relative proportion of secondary GNs and genetic predispositions. We assessed the overall and sub-regional prevalence of primary GN and its histologic subtypes in Africa. We searched PubMed, EMBASE and African Journals Online for studies of biopsy-proven primary GNs across all age groups in Africa published between 2010 and 2022. Data for primary GNs [minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), mesangioproliferative GN (MesPGN), membranoproliferative GN (MPGN), post-infectious GN (PIGN), IgA Nephropathy (IgAN), and crescentic GN (CresGN)] were extracted. Pooled prevalence was determined using the random effects model. Seventeen eligible articles (n = 6,494 individuals) from 8 African countries met the inclusion criteria. The overall pooled prevalence of FSGS, MCD, MN, MPGN, MesPGN, PIGN, IgAN and CresGN was 26.10%, 22.40%, 8.40%, 6.40%, 6.40%, 2.60%, 2.60%, 1.40%, respectively. Only 4 studies (23.5%) used light microscopy (LM), immunofluorescence (IF), and electron microscopy (EM) for diagnosis. There were significant differences in the distribution of histologic subtypes in the paediatric compared to the adult population and across geographic sub-regions, with West Africa having a higher prevalence of FSGS. Overall, the dominance of FSGS across most regions and age groups has implications for disease diagnosis and ongoing care. Research efforts to understand the impact of this trend on kidney disease outcomes and efforts to improve kidney biopsy practice as a means of early disease detection are needed in Africa.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prevalence and distribution of primary glomerular diseases in Africa: a systematic review and meta-analysis of observational studies

Ekrikpo,

Obiagwu,

Udo

et al. 2023

Pan Afr Med J

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“…In Africa, the epidemiology of AKI is thought to be different due to the different rates of exposure to risk factors [8]. In Sudan, there is little published data about the burden and outcomes of AK [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%