Epidemiology of acute cerebrovascular disease before the age of 55 in the Stockholm County 1973-77: I. Incidence and mortality rates.

Mettinger, K.L.; Söderström, C.E.; Allander, Erik

doi:10.1161/01.str.15.5.795

Cited by 36 publications

(13 citation statements)

References 36 publications

(8 reference statements)

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“…4,5,10 Furthermore, we found a trend (Pϭ0.059) toward higher incidence among women aged Ͻ30 years than among men, whereas men significantly outnumbered women in older age groups, which is compatible with the findings of Lidegaard et al 4 in Denmark.…”

Section: Discussionsupporting

confidence: 91%

Incidence and Short-Term Outcome of Cerebral Infarction in Young Adults in Western Norway

Næss

Nyland

Thomassen

et al. 2002

Stroke

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Background and Purpose-We sought to determine the incidence and short-term outcome of people aged 15 to 49 years with first-ever cerebral infarction in 1988 -1997 in Hordaland County, Norway. Methods-Cases were found from computer search of hospital registries and detailed review of patient records. Stroke subtype was classified according to the major intracranial artery affected. Short-term outcome was evaluated by the modified Rankin Scale (mRS). Results-A total of 96 women and 136 men met the inclusion criteria. The average annual incidence was 11.4/100 000.Women outnumbered men among those aged Ͻ30 years (Pϭ0.059); men predominated among those aged Ն30 years (Pϭ0.004). A total of 148 patients had anterior circulation infarction (64%), and 84 had posterior circulation infarction (36%) (PϽ0.001). Patients with posterior circulation infarction had better mRS score at discharge (Pϭ0.005). Eighty percent had favorable outcome (mRS score Յ2). The 30-day case fatality rate was 3.4%. The recurrence rate in hospital was 2.2%. Key Words: cerebral infarction Ⅲ incidence Ⅲ outcome Ⅲ young adults T he incidence of ischemic stroke increases with age, but the incidence among young adults is not negligible. We sought to determine the average annual incidence rate of first-ever cerebral infarction, classify stroke subtypes, and evaluate the short-term outcome of people aged 15 to 49 years in a well-defined population. To our knowledge, this is the first population-based report on short-term functional outcome of cerebral infarction in young adults. Conclusions-The Subjects and Methods PatientsAll patients aged 15 to 49 years with first-ever cerebral infarction during 1988 -1997 living in Hordaland County, Norway, for at least 5 years before the stroke occurred were included. Cases were found by computer search from hospital registries at each of the 5 acute care hospitals in the county. The searching criteria were patients admitted to either an inpatient or an outpatient department and discharged with a diagnosis of primary or secondary stroke: categories 430 to 438 of the International Classification of Diseases, Ninth Revision.Cerebral infarction was defined in accordance with the BaltimoreWashington Cooperative Young Stroke Study Criteria. 1 This definition includes patients who have neurological deficits lasting Ͼ24 hours because of ischemic lesions and patients with transient ischemic attacks in whom CT or MRI shows infarctions related to the clinical findings. We excluded patients with cerebral infarction associated with other intracranial diseases such as subarachnoid hemorrhage, sinus venous thrombosis, or severe head trauma. Case selection and classification were based on the examination of the neurologist in charge of treatment and follow-up of the patient as well as critical review of patient records.Stroke subtypes were categorized according to the intracranial artery involved on the basis of the neurological deficits and CT or MRI findings.Neurological deficits on admission and discharge were categorized into no...

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Section: Discussionsupporting

confidence: 91%

Incidence and Short-Term Outcome of Cerebral Infarction in Young Adults in Western Norway

Næss

Nyland

Thomassen

et al. 2002

Stroke

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“…13 A recent Swedish survey based on data from hospital admissions, suggests an incidence as low as 4/100000/year under the age 55. 6 The authors assume that nearly all TLA cases are referred for specialist evaluation, a view which is clearly open for debate. In comparison, The Rochester Study, 3 also based on medical records, gives an incidence of 16/100000/year in the 45-54 year group.…”

Section: Discussionmentioning

confidence: 99%

Transient cerebral ischemic attacks in the young and middle aged. A population study.

Johnson¹,

Skre²

1986

Stroke

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SUMMARY During an investigation of coronary risk factors, a population 20 to 54 years old in Troms0, Northern Norway was screened for transient ischemic cerebral attacks. Three simple screening questions were used. Sixteen thousand six hundred and twenty-one subjects participated in the study. Among the responders, a sample of 501 were evaluated neurologicaliy and 10 men and 16 women identified as TIA cases. Mean age for men was 41.3 years, for women 33 years. Five women (mean age 24.4) had the events during pregnancy, pointing to pregnancy as a period of risk. Five-year incidence was found to be 2.5. per 1000. Clinical expressions and ratio carotid to vertebral-basilar TLA hardly differed from that found hi materials of older patients. All 26 remained stroke-free during a mean observation period of 55 months. Known risk factors like hypertension, carotid stenosis and cardiac disease were found in only a few. Five women had low blood pressure. It is suggested that TLA in younger age groups may constitute a separate entity where, among other, haemodynamk factors and pregnancy play a role.

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“…Other population-based TIA incidence rates range from 18 per 100,000 persons per year from 1987 to 1988 in Novosibirsk, Russia [9] to 37 per 100,000 persons per year from 1970-1973 in Estonia [10]. Data from Sweden, England, France, and Japan have also been within this range [11][12][13][14]. The higher rates in the Rochester study may reflect distinct methods of case ascertainment because incidence rates for ischemic stroke are comparable.…”

Section: Prevalence and Incidencementioning

confidence: 92%

Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy

2011

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Stroke is the fourth killer and number one cause of adult disability in the United States. The estimated direct and indirect costs of stroke care in this country are $68.9 billion for 2009. The prevalence of stroke and its cost will undoubtedly rise as the aging population increases. In addition, stroke incidence and mortality are increasing in less developed countries in which the lifestyles and population restructuring are rapidly changing. More population-based research to assess incidence, risk factors, and outcomes are needed in these countries. Epidemiologic studies can help identify groups of individuals or regions at higher risk for stroke. They can also help us better understand the natural history of certain conditions and therefore push the direction of therapeutic investigations. Furthermore, the study of trends across different time periods and different populations can help investigators evaluate the effects of stroke care programs and treatment options.

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Epidemiology of acute cerebrovascular disease before the age of 55 in the Stockholm County 1973-77: I. Incidence and mortality rates.

Cited by 36 publications

References 36 publications

Incidence and Short-Term Outcome of Cerebral Infarction in Young Adults in Western Norway

Incidence and Short-Term Outcome of Cerebral Infarction in Young Adults in Western Norway

Transient cerebral ischemic attacks in the young and middle aged. A population study.

Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy

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