Epidemiology, natural history, and risk factors: Panel report from the Ninth International Research Conference on Otitis Media

Daly, Kathleen A.; Hoffman, Howard J.; Kværner, Kari J.; Kvestad, Ellen; Casselbrant, Margaretha L.; Homøe, Preben; Rovers, Maroeska M.

doi:10.1016/j.ijporl.2009.09.006

Cited by 106 publications

(91 citation statements)

References 70 publications

(87 reference statements)

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“…Many epidemiological studies have shown that male children are more likely to be affected with COME/ROM than females (Auinger et al 2003;Damoiseaux et al 2006;Daly et al 2010). Despite evidence of a gender bias, analysis of the X chromosome from our GWAS data did not result in any significant loci associated with COME/ROM.…”

Section: Discussioncontrasting

confidence: 62%

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A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2

Allen

Chen

Weeks

et al. 2013

JARO

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Chronic otitis media with effusion (COME) and recurrent otitis media (ROM) have been shown to be heritable, but candidate gene and linkage studies to date have been equivocal. Our aim was to identify genetic susceptibility factors using a genome-wide association study (GWAS). We genotyped 602 subjects from 143 families with 373 COME/ROM subjects using the Illumina Human CNV370-Duo DNA Bead Chip (324,748 SNPs). We carried out the GWAS scan and imputed SNPs at the regions with the most significant associations. Replication genotyping in an independent family-based sample was conducted for 53 SNPs: the 41 most significant SNPs with PG10 −4 and 12 imputed SNPs with PG10 −4 on chromosome 15 (near the strongest signal). We replicated the association of rs10497394 (GWAS discovery P= 1.30×10 −5 ) on chromosome 2 in the independent otitis media population (P=4.7×10 −5 ; meta-analysis P= 1.52×10 −8 ). Three additional SNPs had replication PvaluesG0.10. Two were on chromosome 15q26.1 including rs1110060, the strongest association with COME/ROM in the primary GWAS (P=3.4×10 −7 ) in KIF7 intron 7 (P=0.072), and rs10775247, a nonsynonymous SNP in TICRR exon 2 (P=0.075). The third SNP rs386057 was on chromosome 5 in TPPP intron 1 (P=0.045). We have performed the first GWAS of COME/ROM and have identified a SNP rs10497394 on chromosome 2 is significantly associated with COME/ROM susceptibility. This SNP is within a 537 kb intergenic region, bordered by CDCA7 and SP3. The genomic and functional significance of this newly identified locus in COME/ROM pathogenesis requires additional investigation.

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Section: Discussioncontrasting

confidence: 62%

“…Every year, over 10 million children in the United States are treated for otitis media (OM), the inflam-mation of the middle ear (Gunasekera et al 2007;Daly et al 2010). OM is a leading reason for physician visits during childhood and represents a major component of the pediatric health care burden (Grevers 2010).…”

Section: Introductionmentioning

confidence: 99%

A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2

Allen

Chen

Weeks

et al. 2013

JARO

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“…[1] Estimates suggest that 80% of children will have at least one episode of acute otitis media (AOM) before 3 years of age. [2] A global incidence study reported an AOM incidence rate of 10.9%.…”

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confidence: 99%

“…[3] The epidemiology of otitis media, and reasons for regional differences in incidence and prevalence are complex, with risk factors involving multiple host-related factors (age, gender, race, allergy, immune competence specifically related to HIV status, malnutrition, craniofacial abnormalities, genetic predisposition) and environmental factors (upper respiratory infection, seasonality, daycare, presence of siblings, tobacco smoke exposure, breastfeeding, socioeconomic status). [1,3,4,6] HIV-positive children are more prone to, and more severely affected by, otitis media than immunocompetent children. [7] An estimated 3 million of the 3.3 million children worldwide who are HIV-positive (0 -14 years of age) live in SSA.…”

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confidence: 99%

“…Paediatric otitis media at a primary healthcare clinic in South Africa L Biagio, 1 MComMPath; D W Swanepoel, [1][2][3] PhD; C Laurent, 1,4 MD, PhD; T Lundberg, 5 MD used previously to diagnose middle-ear pathology. Otomicroscopy, however, offers greater diagnostic sensitivity and specificity than either otoscopy or pneumatic otoscopy, [13] and is therefore likely to provide a more accurate diagnosis, and classification, of otitis media.…”

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confidence: 99%

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Paediatric otitis media at a primary healthcare clinic in South Africa

et al. 2014

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Background.No published studies on the prevalence of paediatric otitis media at primary healthcare clinics (PHCs) in South Africa (SA) are available. Objective. To examine the point prevalence of otitis media in a paediatric population in a PHC in Johannesburg, SA, using otomicroscopy. Methods. A sample of 140 children aged 2 -16 years (mean 6.4; 44.1% females) were recruited from patients attending the PHC. Otomicroscopy was completed for each of the participants' ears by a specialist otologist using a surgical microscope. Results. Cerumen removal was necessary in 36.0% of participants (23.5% of ears). Otitis media with effusion was the most frequent diagnosis (16.5%). Chronic suppurative otitis media (CSOM) was diagnosed in 6.6% of children and was the most common type of otitis media in participants aged 6 -15 years. Acute otitis media was only diagnosed in the younger 2 -5-year age group (1.7%). Otitis media was significantly more prevalent among younger (31.4%) than older children (16.7%). Conclusion. CSOM prevalence, as classified by the World Health Organization, was high. Consequently diagnosis, treatment and subsequent referral protocols may need to be reviewed to prevent CSOM complications.

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Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion

Samuels

Yan

Khampang

et al. 2017

JAMA Otolaryngol Head Neck Surg

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Epidemiology, natural history, and risk factors: Panel report from the Ninth International Research Conference on Otitis Media

Cited by 106 publications

References 70 publications

A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2

A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2

Paediatric otitis media at a primary healthcare clinic in South Africa

Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion

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