“…Therefore, the pathogenesis of this nonallergic AEDS [called intrinsic atopic dermatitis by Wu¨thrich, (67)] seems to be different from the disease known as classical allergic form of AEDS (extrinsic atopic dermatitis). According to Schmid-Grendelmeier, Wu¨thrich et al (68), diagnostic criteria should run as follows: (i) a clinical phenotype AEDS, fulfilling the diagnostic criteria of Hanifin and Rajka (69) (ii) low total serum-IgE levels (< 200 kU/l) in combination with negative in-vitro IgE-screening for aeroallergens and food allergens (e.g., negative SX1-RAST and SX-5 RAST) as well as negative prick test results for standard aero-and food-allergens (iii) absence of other atopic diseases such as allergic rhinoconjunctivitis or allergic bronchial asthma. Hence, patients may initially be considered having a nonallergic AEDS, but during the allergologic workup they may need to be reclassified as allergic AECS and vice versa.…”