Epidemiology, clinical characteristics, and treatment of severe fever with thrombocytopenia syndrome

Li, Jia-Chen; Zhao, Jing; Li, Hao; Fang, Li‐Qun

doi:10.1016/j.imj.2021.10.001

Cited by 30 publications

(20 citation statements)

References 95 publications

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“…Most SFTS patients are elderly with the median age of 63 years and immune function decreases with the increase of age, which is associated with the severity and mortality of the disease 20 . In addition, SFTSV infection can also damage the immune function of SFTS patients through changing the distribution of lymphocytic sub-populations 7 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of predictors for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome

Song

Zhao

Wang

et al. 2023

Sci Rep

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Patients with severe fever with thrombocytopenia syndrome (SFTS) had been confirmed to have immune dysfunction and were prone to invasive pulmonary aspergillosis (IPA), which was directly related to the increased mortality. The aim of this study was to investigate the predictors for IPA in SFTS patients, and the results were expected to be helpful for early identification of IPA and initiation of anti-fungal therapy. The study was performed to review laboratory confirmed SFTS patients in two tertiary hospitals in Shandong province (Qilu Hospital of Shandong University and Shandong Public Health Clinical Center) from April 2021 to August 2022. The enrolled patients were further divided into IPA group and non-IPA group. Demographic characteristics, clinical manifestations and laboratory parameters between IPA group and non-IPA group patients were analyzed and compared to identify the independent predictors for IPA by univariate analysis and multivariable logistic regression analysis. Sensitivity and specificity of independent predictors were evaluated by receiver operating characteristic (ROC) curve analysis. In total, 67 SFTS patients were enrolled with an average age of 64.7 (± 8.4) years old. The incidence of IPA was 32.8% (22/67). Mortality of patients in IPA group was 27.3% (6/22), which was significantly higher than that in non-IPA group. Results of univariate analysis showed that uncontrolled diabetes, central nervous system symptoms, platelet < 40 × 109/L, CD4+ T cell < 300/μL and CD8+ T cell < 400/μL were risk factors for development of IPA. These factors were further analyzed by multivariable logistic regression analysis and the results indicated that uncontrolled diabetes, platelet < 40 × 109/L, CD4+ T cell < 300/μL and CD8+ T cell < 400/μL could be recognized as independent predictors for IPA in SFTS patients. In conclusion, IPA is a serious complication for SFTS patients and increases mortality. It is necessary to early identify predictors of IPA for improving survival of SFTS patients.

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Section: Discussionmentioning

confidence: 99%

Investigation of predictors for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome

Song

Zhao

Wang

et al. 2023

Sci Rep

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“…Interestingly, both Suffolk County, NY and Monmouth County, NJ have had detections of invasive H. longicornis combined with abundant A. americanum populations. H. longicornis is a known capable vector of Dabiebandavirus (Li et al 2022), a close relative of HRTV, and can transmit HRTV transovarially (Raney et al 2022). It has also been found infected with BRBV in Virginia (Cumbie et al 2022) although vector competence is unconfirmed.…”

Section: Discussionmentioning

confidence: 99%

Lone star ticks (Acari: Ixodidae) infected with Bourbon virus in New Jersey, USA

Egizi

Wagner

Jordan

et al. 2023

Journal of Medical Entomology

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Lone star ticks (Amblyomma americanum L.) are expanding within the northeast United States, a region historically focused on Ixodes scapularis-transmitted diseases. In Monmouth County, NJ, the shift has been dramatic, and lone star ticks now vastly outnumber blacklegged ticks. As a result, there is an enhanced need to focus on the potential health risks of A. americanum-transmitted pathogens, such as the emerging Heartland (HRTV) and Bourbon (BRBV) viruses. We screened 1,205 nymphal lone star ticks for HRTV and BRBV using RT-qPCR assays and detected BRBV in 3 ticks collected in Monmouth County, NJ, in 2021. Additionally, we sequenced a complete BRBV genome from a single infected specimen, finding 99.4% identity with human pathogenic isolates from the eastern-central United States. Our results have important public health implications for a region only recently becoming aware of public health risks posed by lone star ticks. Of note, we report successful detection of viral RNA in samples that were stored and intended for DNA preservation, for example, kept in ethanol at room temperature, which may reduce barriers for public health agencies seeking to expand their tick testing to include viruses.

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“…Severe fever with thrombocytopenia syndrome (SFTS) caused by a bunyavirus [SFTS virus (SFTSV)] that was recently named Dabie bandavirus in the family Phenuiviridae (formerly Bunyaviridae) is the most notorious VHF disease, primarily because of its wide geographical distribution and high mortality rate (12 to 50%). Since its first identification in China in 2009 (2), SFTS has affected a rapidly growing number of people, with a consistently expanded geographic distribution, mostly in Asian countries, including China, Korea, Japan, Vietnam, Pakistan, Myanmar, and Thailand (3)(4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus

et al. 2023

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Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus causing a high fatality rate of up to 30%. To date, the receptor mediating SFTSV entry remained uncharacterized, hindering the understanding of disease pathogenesis. Here, C-C motif chemokine receptor 2 (CCR2) was identified as a host receptor for SFTSV based on a genome-wide CRISPR-Cas9 screen. Knockout of CCR2 substantially reduced viral binding and infection. CCR2 enhanced SFTSV binding through direct binding to SFTSV glycoprotein N (Gn), which is mediated by its N-terminal extracellular domain. Depletion of CCR2 in C57BL/6J mouse model attenuated SFTSV replication and pathogenesis. The peripheral blood primary monocytes from elderly individuals or subjects with underlying diabetes mellitus showed higher CCR2 surface expression and supported stronger binding and replication of SFTSV. Together, these data indicate that CCR2 is a host entry receptor for SFTSV infection and a novel target for developing anti-SFTSV therapeutics.

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Epidemiology, clinical characteristics, and treatment of severe fever with thrombocytopenia syndrome

Cited by 30 publications

References 95 publications

Investigation of predictors for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome

Investigation of predictors for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome

Lone star ticks (Acari: Ixodidae) infected with Bourbon virus in New Jersey, USA

CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus

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