Epidemiology and seropositivity of dengue fever cases in a rural tertiary care hospital of western Maharashtra, India

Background: Dengue is one of the most important mosquito borne viral disease with wide spectrum of clinical presentation and often with unpredictable clinical evolution and outcome. Approximately 50 million infections occur annually world-wide, but what’s the real size of the problem in India? Nobody truly knows...!! Present study was carried out to determine seropositivity, clinical profile and seasonal variation of dengue infection in central India.Methods: Study was carried out from January 2012 to December 2016. Blood samples were collected from 15,606 patients with dengue like clinical illness and serum was separated. All the samples were subjected to IgM antibody detection by dengue MAC ELISA.Results: Prevalence of dengue in dengue suspected cases was found to be 24.49% (3,822/15,606). Maximum number of positive cases, 1,548 (40.50%) were in the age group of 0-10 years. Males (60.83%) were affected more than females (39.17%). Peak was observed in the months of August, September, October and November. Common presenting features were fever followed by myalgia, arthralgia, headache and bleeding manifestations. Significant drop in platelet count was observed in patients with dengue shock syndrome and dengue haemorrhagic fever.Conclusions: Number of dengue cases in central India are on increase and continued surveillance is essential to determine epidemiological and seasonal trend.

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“…6 Saini S et al reported seropositivity of 30.6% in western Maharashtra. 10 Sood S reported 18.99% seroprevalence of dengue in Rajasthan, India.…”

Section: Seroprevalence Of Dengue Infectionmentioning

confidence: 99%

Dengue infection in central India: a 5 years study at a tertiary care hospital

2017

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“…1.8:1. [24] Anugha G Kinikar's study shows 1.3:1 [25] but in our study male to female ratio is 1.1:1. This difference in ratio may be due to the paediatric age group where other factors like outdoor working, activity and exposure could not be applied.…”

Section: Discussionmentioning

confidence: 39%

Study of Clinical, Laboratory Profile and Outcome of Dengue Fever Admitted in Paediatric Ward of a Tertiary Care Hospital of Western Uttar Pradesh, India

Kashif¹,

Abqari²,

Zaka-ur-Rab³

et al. 2017

jemds

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BACKGROUNDDengue Fever epidemic resurfaced this year after 2005 with more number of cases and with varying presentations and complications. The presentation can vary from a mild febrile illness to severe refractory shock or severe bleeding. Dengue is an important cause of mortality and morbidity in India. Many recent studies have shown varied clinical manifestations from different geographical locations. The present prospective observational study was conducted to find out the clinical features, complications, response to treatment and outcome of patients suffering from dengue in a tertiary care centre of Western Uttar Pradesh, India. Objective-To study the clinical, pathological, laboratory profile and outcome of the confirmed cases of Dengue fever in Paediatric age group admitted in the hospital. MATERIALS AND METHODSThe Prospective observational study was performed at Department of Paediatrics, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh which is a tertiary care hospital of Western Uttar Pradesh. The study period was from June 2013 to November 2013. Patients up to 18 years of age who were admitted in Paediatric ward and were positive for serological test (NS1 Ag, IgM /IgG) for dengue fever were included. The patients were subjected to detailed history and examination and relevant investigations were sent. RESULTSTotal 126 patients were included. Out of these, 66 were male (52.38%) and 20 were female (47.61%). Majority of them presented in critical phase on day 4-6 of illness (57.14%). Most of the cases were admitted in post monsoon period in the month of October and November. The most common presentation was fever 126 (100%) followed by petechial rash 75 (59.52%). Pruritus was present in 60 (47.61%) patients. NS1 antigen was positive in majority of patients (78, 61.9%). Thrombocytopenia was the commonest haematological abnormality. Deranged hepatic, renal and cerebral functions were noted. Total leucocyte counts were less than 4000 in most of the patients (54, 42.8%). Bleeding manifestations in the form of gum bleeding, haematuria, epistaxis, melaena were present mainly in patients having severe thrombocytopenia (<50,000/cu mm). On ECG 39(23.8%) patients were having myocarditis whereas 24 (19%) patients had pleural effusion on chest x-ray. The average duration of stay in the hospital was 6-7 days and majority of the patients were discharged on day 9-10 of illness. Comorbid conditions in the form of malaria 9 (7.1%) and enteric fever 7 (5.5%) were also noted. Blood cultures were positive in only 8 (6.3%). 8 patients expired and mortality rate was 6.3%. Shock, bleeding, encephalitis, ARDS, late presentation and diagnosis were associated with poor outcome and mortality. CONCLUSIONDengue is an important cause of mortality and morbidity in western Uttar Pradesh and adjoining areas. Community awareness, early diagnosis and management and vector control measures need to be strengthened, during peri-monsoon period, in order to curb the increasing number of dengue cases. High index of...

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“…Additionally, male predominancy was seen that has been reported earlier [10,17] and might be due to the gender bias in seeking healthcare. Secondly, proper covering of body and maximum indoor stay in females could be another reason for this low female predominance.…”

Section: Discussionmentioning

confidence: 59%

Epidemiological Profile and Laboratory Characteristics of Dengue Virus Infection during 2011 Outbreak in Rawalpindi, Islamabad Pakistan

Suleman¹

2016

JHVRV

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A total of 215 serum samples of clinically suspected dengue patients who presented to the tertiary care hospitals over a period of July-November 2011 were analyzed for the detection of dengue NS1 antigen, dengue IgM and IgG antibodies and 180 (83.7%) samples were found positive by one or more than one testing parameters. Of the 180 samples, 98 (54.4%) were positive to NS1, 168 (93.3%) were positive to IgM and 93 (51.6%) cases were positive to IgG only. Similarly, 93 (51.6%) were positive to both NS1 and IgM, 48 (26.6%) to NS1 and IgG, and 83 (46.1%) were positive to both IgM and IgG and 48(26%) were positive for NS1, IgM and IgG.A randomly selected subset of 50 serology positive samples were tested by, one step TaqMan real time fourplex RT-PCR assay. A total of 35/50 (70%) samples were found positive by PCR. Positive rates of dengue serotypes were 15/35 (42.8%), 11/35 (31.4%) and 9/35 (25.7%) for DENV-1, DENV-2 and DENV-3 respectively. No DENV-4 serotype was detected.

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Epidemiology and seropositivity of dengue fever cases in a rural tertiary care hospital of western Maharashtra, India

Cited by 16 publications

References 14 publications

Dengue infection in central India: a 5 years study at a tertiary care hospital

Dengue infection in central India: a 5 years study at a tertiary care hospital

Study of Clinical, Laboratory Profile and Outcome of Dengue Fever Admitted in Paediatric Ward of a Tertiary Care Hospital of Western Uttar Pradesh, India

Epidemiological Profile and Laboratory Characteristics of Dengue Virus Infection during 2011 Outbreak in Rawalpindi, Islamabad Pakistan

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