Epidemiology and Risk Factors for Corneal Graft Rejection

Sellami, Dorra; Abid, Syed; Bouaouaja, G.; Amor, S. Ben; Kammoun, B.; Masmoudi, Mohamed; Dabbeche, K.; Boumoud, H.; Zina, Z. Ben; Feki, J.

doi:10.1016/j.transproceed.2007.08.020

Cited by 54 publications

(27 citation statements)

References 8 publications

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“…For those patients in whom the graft was not rejected, visual function markedly improved, supporting the view that PK is a valuable procedure for patients with corneal ulcer in spite of the associated risks. The graft rejection rate (27.2% of the total cohort) is broadly consistent with values in the literature 20–22…”

Section: Discussionsupporting

confidence: 88%

Outcome of penetrating keratoplasty in corneal ulcer: a single-center experience

Sedghipour

Sorkhabi²,

Shenasi³

et al. 2011

OPTH

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BackgroundCorneal ulcers often lead to scarring and astigmatism, and significant loss of vision is a common consequence.ObjectiveTo determine the rate of graft rejection, one of the most serious concerns with this procedure, and to evaluate the recovery of visual function in those patients for whom the operation was successful.MethodsWe describe a retrospective study of 33 corneal ulcer patients undergoing penetrating keratoplasty (PK) at the Tabriz Nikookari Eye Hospital.ResultsMean age of the patients was 44 ± 14 years. Most common risk factors for active keratitis were trauma, dry eye, and malnutrition. Culture-positive results included bacterial keratitis (n = 15) and fungal keratitis (n = 5). Perforation was a significant risk factor for therapeutic failure (P < 0.05). Age or gender had no statistically significant effects on the PK outcome (P > 0.05). Postoperative visual acuity had a significant association with preoperative visual acuity (P < 0.01). Graft rejection rate (27.2%) was similar to that reported in the literature.ConclusionAlthough lamellar keratoplasty has recently been established, there are practical reasons for continuing the use of PK in centers such as ours, with due attention to the requirement for topical immunosuppression to diminish the rate of graft rejection and antimicrobial treatment to prevent postoperative infection.

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Section: Discussionsupporting

confidence: 88%

Outcome of penetrating keratoplasty in corneal ulcer: a single-center experience

Sedghipour

Sorkhabi²,

Shenasi³

et al. 2011

OPTH

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“…28 However, their clinical efficacy is limited or variable, and all have undesirable side effects. Moreover, corneal transplants in such cases are prone to early rejection [29][30][31][32][33] and keratoprosthesis is associated with a high rate of complications and guarded long-term results. 34 Anti-VEGF agents have been extensively investigated in recent years for the prevention and alleviation of neovascularization in many tissues, including the cornea.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Subconjunctival Aflibercept Versus Bevacizumab for Prevention of Corneal Neovascularization in a Rat Model

Gal-Or

Livny

Sella

et al. 2016

Cornea

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“…Additionally, there is a robust association between the presence of corneal neovascularization and corneal graft rejection with the risk increasing as more quadrants are afected by vessels ( Figure 5) [4][5][6][7]. The presence of corneal neovascularization can also cause intraoperative bleeding, which can be associated with hyphema.…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…Corneal neovascularization is part of the natural healing processes, which are triggered by exposure of the cornea to trauma or pathogens, and is not necessarily 'harmful.' In the long-term and under certain circumstances, however, corneal neovascularization can surpass a threshold, invading the cornea, reducing visual acuity, and, in case of lamellar keratoplasty or penetrating keratoplasty, endangering corneal graft survival [4][5][6][7]. These complications have prompted clinicians to devise means to shut vessels.…”

Section: Introductionmentioning

confidence: 99%

Corneal Angiogenesis: Etiologies, Complications, and Management

Feizi¹

2017

Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy

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A large subset of corneal pathologies involves the formation of new blood vessels, leading to compromised visual acuity. Additionally, neovascularization of the cornea worsens the prognosis of subsequent penetrating keratoplasty, keeping the patient in a vicious circle of poor prognosis. Ocular angiogenesis results from the upregulation of proangiogenic and downregulation of antiangiogenic factors. There is a tremendous need for developing efective measures to prevent and/or treat corneal neovascularization. Topical steroid medication, cautery, argon and yellow dye laser, and ine needle diathermy have all been advocated with varying degrees of success. The process of corneal neovascularization is primarily mediated by the vascular endothelial growth factor family of proteins, and current therapies are aimed at disrupting the various steps in this pathway. This article aims to review the clinical causes and presentations of corneal neovascularization caused by diferent etiologies. Moreover, this chapter reviews diferent complications caused by corneal neovascularization and summarizes the most relevant treatments available so far.

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Epidemiology and Risk Factors for Corneal Graft Rejection

Cited by 54 publications

References 8 publications

Outcome of penetrating keratoplasty in corneal ulcer: a single-center experience

Outcome of penetrating keratoplasty in corneal ulcer: a single-center experience

Efficacy of Subconjunctival Aflibercept Versus Bevacizumab for Prevention of Corneal Neovascularization in a Rat Model

Corneal Angiogenesis: Etiologies, Complications, and Management

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