Epidemiology and prevention of hepatitis B virus infection in China

Lu, Fengmin; Li, Tingting; Liu, S.; Zhang, Hui

doi:10.1111/j.1365-2893.2010.01266.x

Cited by 84 publications

(66 citation statements)

References 18 publications

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“…In our study, the prevalence of anti-HBc (35.7%) and HBsAg (11.1%) among our controls was not lower than the prevalence rate of 30.08 and 9.75% in 1992 in China. 17 Here, we reported an association between chronic infection with HBV and the risk of pancreatic cancer. Furthermore, our results suggested that people who past exposed to HBV (anti-HBc-positive) with evidence of HBV immunity or recovery (anti-HBs-positive) might have a lower risk of pancreatic cancer than those with chronic carrier of HBV (HBsAgpositive/anti-HBc-positive).…”

Section: Discussionmentioning

confidence: 85%

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ABO blood group, hepatitis B viral infection and risk of pancreatic cancer

Wang

Chen

Ren

et al. 2011

Intl Journal of Cancer

116

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Little is known about the role of association between ABO blood type and risk of pancreatic cancer develops through effects on hepatitis B viral (HBV) infection. Our study aimed to determine whether joint ABO blood type and HBV infection could increase the risk for pancreatic cancer. A total of 645 patients with pancreatic adenocarcinoma and 711 age-and sex-matched individuals who had nonmalignant diseases treated at the Sun Yat-sen University Cancer Center in China were retrospectively analyzed. Blood samples were tested for ABO blood type and hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis B e antigen (HBeAg), hepatitis B e antibody (anti-HBe) and hepatitis B core antibody (anti-HBc). Multivariable unconditional logistic regression analysis was used to estimate adjusted odds ratios [AORs] and 95% confidence interval [CI]. Multivariable analysis with adjustment for risk factors showed that A blood type, HBsAg-positive/anti-HBcpositive, anti-HBs-positive/anti-HBc-positive were significantly associated with pancreatic cancer. The estimated AORs (95% CI) were as follows: A blood type, 1.425 (1.071-1.894), HBsAg-positive/anti-HBc-positive, 1.610 (1.125-2.304), anti-HBspositive/anti-HBc-positive, 1.526 (1.159-2.011). The effect of A blood type significantly modified the risk of pancreatic cancer among subjects with anti-HBc-positive (AORs 5 1.882, 95% CI, 1.284-2.760). In our study, we reported an association between A blood type, infection with HBV and pancreatic cancer risk. Moreover, we found a synergism between A blood type and HBV infection in the development of pancreatic cancer.Pancreatic cancer is the fifth most common cancer and the fourth leading cause of cancer-related mortality worldwide.

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Section: Discussionmentioning

confidence: 85%

“…China has now fallen into an intermediate endemic area where HBsAg prevalence rate in the general population is 2-7%. 17 However, infection with HBV is a systemic infectious process. Findings from previous study indicated that HBV DNA sequences were detected in the pancreas, kidney and skin, demonstrating HBV infection of these organs.…”

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confidence: 99%

ABO blood group, hepatitis B viral infection and risk of pancreatic cancer

Wang

Chen

Ren

et al. 2011

Intl Journal of Cancer

116

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“…HBV infection is endemic in some developing countries, including China, affecting nearly 15% of the population (Zhao et al, 2001;Sun et al, 2002;Lu et al, 2010). Meanwhile, Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death among men and women in China, contributing to 0.5 million deaths each year (Xie et al, 2012;She et al, 2013;Deng et al, 214;Liu et al, 2014).…”

Section: )mentioning

confidence: 99%

“…Due to high prevalence of hepatitis B virus (HBV) infection and cancer in some developing countries, especially China, concurrent infection with HBV is not uncommon in cancer patients (Sun et al, 2002;Lu et al,2010;Xie et al, 2012;She et al, 2013;Deng et al, 2014;Liu et al, 2014). Recently, the association of HBV infection and cancer has been extensively investigated.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Virus Infection Is Associated with Poor Prognosis in Patients with Advanced Non Small Cell Lung Cancer

Peng¹,

Li²,

Lin³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…However, a previous study has estimated that 93 million individuals of the Chinese population are infected with chronic HBV, which may eventually result in significant public health problems in the future (29). Patients with HBV infection that is accompanied by cirrhosis are in high risk of hepatocarcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Increased glyceraldehyde-3-phosphate dehydrogenase expression indicates higher survival rates in male patients with hepatitis B virus-accociated hepatocellular carcinoma and cirrhosis

Liu

Zhu

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Elevated expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported in different human malignancies. To understand its role in hepatitis B virus (HBV) infection-associated hepatocellular carcinoma (HCC), the expression of GAPDH was quantitatively measured in a cohort of 72 male HCC patients without preoperative treatment, all with evidence of chronic HBV infection. Using C-terminal banding protein 1 (CTBP1) or hypoxanthine phosphori bosyltransferase 1 (HPRT1) as reference genes, the level of GAPDH mRNA in tumor tissue was found to be significantly higher compared with that in paired non tumor tissues (P=0.0087 for CTBP1; P=0.0116 for HPRT1). Accordingly, compared with the non-tumor tissue, 37.5% (27/72) of patients' tumor tissues had a more than 2-fold increase of GAPDH expression. Furthermore, following knockdown GAPDH expression via siRNA transient transfection, HepG2 cells exhibited enhanced resistance to cytosine arabinoside (IC 50 , 308.28 µM vs. 67.68 µM in the control; P=0.01). Notably, higher GAPDH expression was significantly associated with lower liver fibrosis score (P= 0.0394) and a tendency towards higher survival rates for patients with HCC. To the best of our knowledge, the present study is the first study to report that the elevated expression levels of GAPDH in HCC tumor tissue may be relevant to an improved fibrosis score and survival probability in male patients with HBV infection; however, the underlying mechanism requires further investigation. IntroductionHepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality in males and the sixth leading cause in females worldwide (1). In addition, HCC is ranked as the second leading cause of cancer-related mortality in China (2). Over 50% of the annual HCC cases reported worldwide are diagnosed in the Chinese population (3), while hepatitis B virus (HBV) infection is responsible for 80% of all HCC causes in China (4). While a number of studies have revealed that HBV infection is the key pathogenic factor for the development of HCC, male gender and cirrhosis have also been found to be independent risk factors for the occurrence of HCC (5-7). However, few studies exist on patients presenting all these risk factors.Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was initially considered to be an essential glycolytic enzyme that is expressed in all prokaryotic and eukaryotic organisms. GADPH plays a major role in cellular metabolism, converting glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate (8). In addition, studies have demonstrated that GAPDH is involved in certain important physiological functions, including the transport of transfer RNA (9), translational control (10)

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Epidemiology and prevention of hepatitis B virus infection in China

Cited by 84 publications

References 18 publications

ABO blood group, hepatitis B viral infection and risk of pancreatic cancer

ABO blood group, hepatitis B viral infection and risk of pancreatic cancer

Hepatitis B Virus Infection Is Associated with Poor Prognosis in Patients with Advanced Non Small Cell Lung Cancer

Increased glyceraldehyde-3-phosphate dehydrogenase expression indicates higher survival rates in male patients with hepatitis B virus-accociated hepatocellular carcinoma and cirrhosis

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