Epidemiology and Outcome of Major Congenital Malformations in a Large German County

Wittekindt, Boris; Schloesser, Rolf; Doberschuetz, Nora; Salzmann‐Manrique, Emilia; Grossmann, J; Misselwitz, B.; Rolle, Udo

doi:10.1055/s-0038-1642630

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…In these countries, the healthcare system is not prepared enough to manage these patients, leading to death in the early years of life in most cases. On the other hand, in high-income countries, 25-30% of the patients will die in infancy, 25-30% will have a chronic physical or mental disability, even with treatment, and 40-50% will have their condition cured or significantly improved by therapeutic interventions, most commonly surgery (Christianson et al, 2006;García, 2018;Sitkin, Ozgediz, Donkor, & Farmer, 2015).…”

Section: Introductionmentioning

confidence: 99%

Description and results of birth defects surveillance and follow‐up programs in Bogotá and Cali, Colombia, 2002–2019

Zarante

Carreño-Martinez

Ibañez

et al. 2021

American J of Med Genetics Pt C

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Birth defects are structural or functional defects present at birth and are caused by different factors that affect intrauterine development. They are the second most common cause of death under five years of age in Latin America and the Caribbean. In Bogotá and Cali, Colombia, there are two surveillance programs established to evaluate the prevalence of them. The purpose of the following article is to describe the experience and results of the surveillance of the Birth Defects Surveillance Programs in Bogotá and Cali, Colombia, 2002-2019. The information was taken from the surveillance programs that have an active hospital system in some institutions of the city (ECLAMC modality), and use data from the passive national system (Sistema Nacional de Vigilancia en Salud Pública -SIVIGILA) to expand their coverage. From 2002 until 2019, 1,289.650 births have been monitored through one of the surveillance programs, including both methodologies. The importance of surveillance programs relies on the amount of data obtained that allows the development of research, the detection of potential changes throughout time, and the guidance of public policies to improve promotion and prevention strategies.

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Section: Introductionmentioning

confidence: 99%

Description and results of birth defects surveillance and follow‐up programs in Bogotá and Cali, Colombia, 2002–2019

Zarante

Carreño-Martinez

Ibañez

et al. 2021

American J of Med Genetics Pt C

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“…In recent years, the attention of many scientists is focused on determination of the patterns of prenatal morphogenesis and the formation of topographic anatomical interrelations of human organs, vessels and nerves, which is important for ascertaining of morphological preconditions of the possible occurrence of anatomical variants and congenital malformations (CM). The CM incompatible with life dominate among the causes of early neonatal mortality: almost 26% of cases of perinatal and neonatal mortality are associated with congenital pathology of the child 1 . According to the US National Statistical Register, aortic diseases are in the top ten among the first 113 causes of death 2 .…”

Section: Introductionmentioning

confidence: 99%

The sources of innervation of the aortic arch and thoracic aorta in human fetuses

Stelmakh¹,

Хмара²,

LUKASHEVYCH³

et al. 2021

Arch Balk Med Union

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Sources d'innervation de l'arc aortique et de l'aorte thoracique dans le foetus humainIntroduction. Le développement de l'angiochirurgie mène les morphologues à clarifier plus en détail les caractéristiques topographiques et anatomiques des vaisseaux artériels, en tenant compte de leur morphogenèse, des caractéristiques d'innervation, de l'âge et de la variabilité anatomique individuelle à différentes périodes de l'ontogenèse humaine. L'objectif de l'étude est d'analyser les sources et les caractéristiques de l'innervation de l'arc aortique et de l'aorte thoracique chez les foetus humains. Matériaux et méthodes. L'étude a été réalisée sur 36 préparations de foetus humains de 81,0 à 375,0 mm de longueur pariétale-coccygienne en utilisant un ensemble de méthodes : la préparation macro-microscopique, l'injection vasculaire, l'application de contraste, la réalisation de modèles de reconstruction 3D, la morphométrie. Résultats. Les sources d'innervation de l'arc aortique chez les foetus humains sont les branches cardiaques cervicales des nerfs vagues, les nerfs cardiaques cervicaux et les branches uniques des trois ou quatre noeuds thoraciques supérieurs des troncs sympathiques. L'innervation de l'aorte thoracique est assurée par les branches du plexus aortique thoracique, le tronc

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“…Gastroschisis is a congenital defect of the anterior abdominal wall characterized by the absence of a membrane covering the herniated viscera. Gastroschisis occurs in 2-5 of every 10,000 live births and is increasing in incidence [1,2]. While the exact etiology of the disease is unknown, a vascular defect is suspected [3].…”

Section: Introductionmentioning

confidence: 99%

Sutureless closure: a versatile treatment for the diverse presentations of gastroschisis

Grabski

Vavolizza

et al. 2019

J Perinatol

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Objective Case series have demonstrated sutureless closures to be safe for the correction of gastroschisis. We hypothesize that sutureless closure is efficacious in patients requiring silo reduction without need for intubation. Study design We conducted a retrospective case control study of infants who underwent gastroschisis repair at our institution (January 2011-August 2018). Patient characteristics and clinical outcomes were compared between sutureless closure and primary fascial repair groups. Results Seventeen patients in the sutureless group and 28 patients in the primary fascial repair group were included. Success of sutureless closure was 94%. Mechanical ventilation was reduced by 2.8 days in the sutureless group (P < 0.0001) and fewer patients required general anesthesia (29.4% vs. 100%, P < 0.0001). Conclusions Sutureless closure is effective for the diverse presentations of gastroschisis. Given the concerns of effects of general anesthesia on the developing brain, sutureless closure should be strongly considered.

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Epidemiology and Outcome of Major Congenital Malformations in a Large German County

Abstract: Epidemiology and outcome of major congenital malformations in Hesse, Germany, are comparable to previously published data. In addition, our data revealed a volume-outcome association with regard to the length of hospital stay.

Cited by 10 publications

References 30 publications

Description and results of birth defects surveillance and follow‐up programs in Bogotá and Cali, Colombia, 2002–2019

Description and results of birth defects surveillance and follow‐up programs in Bogotá and Cali, Colombia, 2002–2019

The sources of innervation of the aortic arch and thoracic aorta in human fetuses

Sutureless closure: a versatile treatment for the diverse presentations of gastroschisis

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