Epidemiology and outcome of acute kidney injury in children, a single center study

Keenswijk, Werner; Vanmassenhove, Jill; Raes, Ann; Dhont, Evelyn; Vandewalle, Johan

doi:10.1080/17843286.2017.1302625

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…Mean age of AKI presentation in our examination was 6.28 years. It is similar as in Norway 6.0 years, and Belgium 6.1 years, while in Nigeria was 4.8 years ( 14 , 15 , 16 ). For many years the diagnosis and management of AKI was based on the concept of classification to three main categories: prerenal, intrinsic (renal) and postrenal.…”

Section: Discussionsupporting

confidence: 72%

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The Causes of Acute Kidney Injury in Critically Ill Children Who Needs Renal Replacement Therapy

Pokrajac

Hadžimuratović

Mustajbegović-Pripoljac

et al. 2022

Med Arch

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Background: Acute kidney injury (AKI) is the result of various causes and is associated with significant morbidity and mortality as well as long-term renal sequelae in pediatric patients. Objectives: The aim of the study is to determine the causes of AKI in pediatric patients who needed renal replacement therapy (RRT) and were admitted to the Pediatric and Neonatal Intensive Care Unit (PICU and NICU) at the Pediatric Clinic, University Clinical Center Sarajevo (UCCS). Methods: Our research included 81 children with AKI who needed RRT. We used the Kidney Disease: Improving Global Outcomes (KDIGO) criteria to define AKI. Severe acute kidney injury was defined as stage 2 or 3 of AKI when plasma creatinine level ≥2 times the baseline level or urine output <0.5 ml per kilogram of body weight per hour for ≥12 hours. Other laboratory findings and imaging tests were made depending on their primary disease that led to the AKI and its complications. Results: Our research analyzed 81 children with AKI who needed RRT 38 girls and 43 boys ages from birth to 18 years. Mean age of presentation was 6.28 years. Male female ratio in this study was 1.1:1. Non-olyguric AKI was diagnosed in 12 (14.8%) of children with AKI, while the rest 69 (85.2%) had the olyguric type. Patients with AKI were analyzed after a rough division on prerenal in 57 (70.4%) children, intrarenal in 23 (28.4%) and post-renal in 1 (1.2%) patient. Conclusion: As the AKI plays a key role in the mortality and morbidity in pediatric patients, especially in infants, it is important to recognise and treatment on time different etiologies of this serious condition. Some causes of AKI in our country can be prevented by better organization of primary and secondary health care, which would also reduce mortality and morbidity from AKI.

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Section: Discussionsupporting

confidence: 72%

“…As in our study, in most studies, the incidence of boys with AKI is higher in relation to girls. So, in one multicentric study in United States of America 56.4% ( 13 ), in Norway 53% ( 14 ), in Belgium 50.8% ( 15 ) and in Nigeria 68.6% were males ( 16 ).…”

Section: Discussionmentioning

confidence: 96%

The Causes of Acute Kidney Injury in Critically Ill Children Who Needs Renal Replacement Therapy

Pokrajac

Hadžimuratović

Mustajbegović-Pripoljac

et al. 2022

Med Arch

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“…Al-Qatibi et al (25) found that the severity of renal impairment at baseline did not affect the risk of long-term renal impairment. On the other hand, Keenswijk et al reported that being in the 'Failure' group at the time of AKI was significantly associated with CKD in the sixth month after AKI in children (26).…”

Section: Discussionmentioning

confidence: 99%

Çocuklarda Akut Böbrek Hasarı Sonrası Uzun Dönem Böbrek Fonksiyonları

Çelebi¹,

Yazılıtaş²,

Aydoğ³

et al. 2021

Turkish Journal of Pediatric Disease

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Objective: It is widely accepted that an acute kidney injury (AKI) episode has long-term consequences such as chronic kidney disease. But the risk factors for poor renal outcome after an AKI episode are not well defined in paediatric age group. The aim of this study is to evaluate the first and fifth-year renal functions of the patients who undergo AKI during their hospital admission and to determine the risk factors affecting renal functions.Material and Methods: 219 patients who underwent AKI from 2008 to 2012 were included in this study. 62 patients survived less than 1 year. The first and the fifth-year serum creatinine concentrations of the remaining 157 patients were reviewed retrospectively.Results: Patients who were ≤2 years of age and patients who were in Failure+Loss group at the time of AKI had significantly lower estimated Glomerular Filtration Rate (eGFR) values in the first and fifth year after AKI compared to patients who were>2 years of age and patients who were in Risk+Injury group. 25.7% and 40.3% of the patients had abnormal eGFR in the first and fifth year after AKI respectively. In a logistic regression model, factors associated with having abnormal eGFR in the first and fifth year after AKI included younger age but not an advanced degree of AKI. Conclusion:The previous episode of AKI could cause harmful effects on renal functions of children in the long term. Younger age and advanced stage of AKI are associated with worse renal functions after an episode of AKI.

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“…According to the lesion and cause, acute kidney injury can be divided into 3 categories: prerenal, renal, and postrenal, and each has a different etiology and pathophysiology. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Nitrite-induced acute kidney injury with secondary hyperparathyroidism

Peng

Yang

et al. 2018

Medicine

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Rationale:Acute kidney injury (AKI) with hyperparathyroidism caused by nitrite was rare, and renal function and parathyroid hormone (PTH) decreased to normal range after therapy.Patient concerns:Acute kidney injury was diagnosed in a 40-year-old male with hyperparathyroidism and cyanosis of his hands and both forearms.Diagnoses:The patient ate some recently pickled vegetables, and he experienced nausea, vomiting and diarrhoea without oliguria or anuria; Additionally, his hands and both forearms had a typical blue ash appearance. After admission, the laboratory findings indicated theincreasing serum creatinine (Scr) and parathyroid hormone (PTH). He was diagnosed as acute kidney injury with hyperparathyroidism caused by nitrite.Interventions:The patient stopped eating the pickled vegetables and was given rehydration, added calories and other supportive therapy without any glucocorticoids.Outcomes:According to his clinical manifestations, laboratory findings and imaging results, the patient was diagnosed with acute kidney injury with secondary hyperparathyroidism. He was given symptomatic supportive care therapy. After one week, the serum creatinine, parathyroid hormone (PTH), hypercalcemia, hyperphosphatemia, proteinuria, and urine red blood cell values decreased to normal range.Lessons:Nitrite-induced acute kidney injury with secondary hyperparathyroidism was relatively rare. After therapy, the function of the kidney and parathyroid returned to normal. This case suggests that detailed collection of medical history, physical examination and correct symptomatic treatment is very important.

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Epidemiology and outcome of acute kidney injury in children, a single center study

Cited by 12 publications

References 26 publications

The Causes of Acute Kidney Injury in Critically Ill Children Who Needs Renal Replacement Therapy

The Causes of Acute Kidney Injury in Critically Ill Children Who Needs Renal Replacement Therapy

Çocuklarda Akut Böbrek Hasarı Sonrası Uzun Dönem Böbrek Fonksiyonları

Nitrite-induced acute kidney injury with secondary hyperparathyroidism

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