Çocuklarda Akut Böbrek Hasarı Sonrası Uzun Dönem Böbrek Fonksiyonları

Abstract

Objective: It is widely accepted that an acute kidney injury (AKI) episode has long-term consequences such as chronic kidney disease. But the risk factors for poor renal outcome after an AKI episode are not well defined in paediatric age group. The aim of this study is to evaluate the first and fifth-year renal functions of the patients who undergo AKI during their hospital admission and to determine the risk factors affecting renal functions.Material and Methods: 219 patients who underwent AKI from 2008 to 2012 were included in this study. 62 patients survived less than 1 year. The first and the fifth-year serum creatinine concentrations of the remaining 157 patients were reviewed retrospectively.Results: Patients who were ≤2 years of age and patients who were in Failure+Loss group at the time of AKI had significantly lower estimated Glomerular Filtration Rate (eGFR) values in the first and fifth year after AKI compared to patients who were>2 years of age and patients who were in Risk+Injury group. 25.7% and 40.3% of the patients had abnormal eGFR in the first and fifth year after AKI respectively. In a logistic regression model, factors associated with having abnormal eGFR in the first and fifth year after AKI included younger age but not an advanced degree of AKI. Conclusion:The previous episode of AKI could cause harmful effects on renal functions of children in the long term. Younger age and advanced stage of AKI are associated with worse renal functions after an episode of AKI.