Epidemiology and genetics

Bankier, Alan T.; Brady, Jocelyn; Myers, N. A.

doi:10.1007/978-1-4899-3079-8_2

Cited by 18 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other reports of increased frequency of twins with OA support this association [8,13,27]. There have been 173 reported cases of OA in twins [1,4,8,13,15,26,27,31,34], of which 80% have occurred in same-sex pairs [13,27]. There are reports of 15 sets of twins concordant for the OA anomaly [4,8,15,26,27,34].…”

Section: Discussionmentioning

confidence: 80%

“…Within the New South Wales study population, twins represented 5% of infants with OA and in the Victoria population during a 10-year subperiod 7% of infants with OA were aected twins [1]. This is at least double the expected birth rate of twins, and indicates a likely association between twinning and OA.…”

Section: Discussionmentioning

confidence: 96%

“…The rate of twin births in New South Wales is 2.5% [25] and in Victoria 2.3% [1]. Within the New South Wales study population, twins represented 5% of infants with OA and in the Victoria population during a 10-year subperiod 7% of infants with OA were aected twins [1].…”

Section: Discussionmentioning

confidence: 99%

“…[1,8,13]. Aected infants in conjoined twins [22], with a parasitic twin [24], and in triplet pregnancies [13,27] have also been reported.…”

Section: Introductionmentioning

confidence: 90%

“…The more frequent occurrence of OA in multiple pregnancies is unrelated to the infant's identical or non-identical status. Usually OA aects only one twin, and reports of twins concordant for the oesophageal defect are uncommon [1,4,8,15,26,27,34]. Only 1% of siblings or ospring of OA individuals are aected [33].…”

Section: Introductionmentioning

confidence: 95%

See 4 more Smart Citations

Oesophageal atresia in twins

Orford

Glasson

Beasley

et al. 2000

Pediatric Surgery International

View full text Add to dashboard Cite

The twin incidence is higher in infants with oesophageal atresia (OA) than in the general population. The purpose of this study was to review the twin OA information from five institutions and evaluate possible links between the development of OA and the twinning process. Data were compared, combined, and analysed. There was a total of 1,215 infants with OA, of whom 50 were from a twin pregnancy and 1 from a triplet pregnancy. Two sets of twins were concordant for OA. Mean birth weights and gestational ages were lower in the twin infants (P < 0.0005) and survival was lower in twins (65%, P < 0.005) than singletons. The anatomical variant of pure OA without fistula was seen in proportionally fewer twins (4%) than in singletons (7%). Multiple anomalies were present in 40% of twins compared with 33% of singletons, although this did not reach statistical significance. OA in our multicentre population was more common in twins. Several possible mechanisms are put forward to explain the apparent link between twinning and OA. Further analysis of this aspect of OA may aid in understanding the aetiology of this congenital anomaly.

show abstract