Poisson versus logistic regression in a descriptive epidemiologic analysis of data from a Birth Defects Registry

Langlois, Peter H.; Canfield, Mark A.; Swartz, Michael D.

doi:10.1002/bdra.23167

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…The investigation of the impact of diabetes, including type 1 diabetes mellitus and type 2 diabetes, on in‐hospital events and in‐hospital death among PE patients was carried out using univariate and multivariate logistic regression models given as odds ratio (OR) and 95% CI. Logistic regression analysis is widely used in epidemiological studies concerned with quantifying an association between a study factor (i.e., an exposure variable) and a health outcome (i.e., disease status, binary data) 30 .…”

Section: Methodsmentioning

confidence: 99%

Diabetes mellitus and its impact on mortality rate and outcome in pulmonary embolism

Schmitt

Hobohm

Sivanathan

et al. 2021

J of Diabetes Invest

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Aims/Introduction In patients with pulmonary embolism (PE), the impact of diabetes mellitus on patient profile and outcome is not well investigated. Material and Methods The German nationwide inpatient sample of the years 2005–2018 was analyzed. Hospitalized PE patients were stratified for diabetes, and the impact of diabetes on in‐hospital events was investigated. Results Overall, 1,174,196 PE patients (53.8% aged ≥70 years, 53.5% women) and, among these, 219,550 (18.7%) diabetes patients were included. In‐hospital mortality rate amounted to 15.8%, and was higher in diabetes patients than in non‐diabetes patients (19.8% vs 14.8%, P < 0.001). PE patients with diabetes had a higher prevalence of cardiovascular risk factors, comorbidities, right ventricular dysfunction (31.8% vs 27.7%, P < 0.001), prolonged in‐hospital stay (11.0 vs 9.0 days, P < 0.001) and higher rates of adverse in‐hospital events. Remarkably, diabetes was independently associated with increased in‐hospital mortality (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.20–1.23, P < 0.001) when adjusted for age, sex and comorbidities. Within the observation period of 2005–2018, a relevant decrease of in‐hospital mortality in PE patients with diabetes was observed (25.5% to 16.8%). Systemic thrombolysis was more often administered to diabetes patients (OR 1.18, 95% CI 1.01–3.49, P < 0.001), and diabetes was associated with intracerebral (OR 1.19, 95% CI 1.12–1.26, P < 0.001), as well as gastrointestinal bleeding (OR 1.11, 95% CI 1.07–1.15, P < 0.001). Type 1 diabetes mellitus was shown to be a strong risk factor in PE patients for shock, right ventricular dysfunction, cardiopulmonary resuscitation and in‐hospital death (OR 1.75, 95% CI 1.61–1.90, P < 0.001). Conclusions Despite the progress in diabetes treatments, diabetes is still associated with an unfavorable clinical patient profile and higher risk for adverse events, including substantially increased in‐hospital mortality in acute PE.

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Section: Methodsmentioning

confidence: 99%

Diabetes mellitus and its impact on mortality rate and outcome in pulmonary embolism

Schmitt

Hobohm

Sivanathan

et al. 2021

J of Diabetes Invest

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“…Poisson regression was used to compare the prevalence of each CHD phenotype (outcome) between boys born with hypospadias and boys born without hypospadias (exposure). 34 All models were adjusted for maternal race and ethnicity (Hispanic, non-Hispanic Black, non-Hispanic White, and other or…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clustering of Congenital Heart Defects Among Boys With Hypospadias

et al. 2022

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Key Points Question What is the relative prevalence of congenital heart defects among boys born with hypospadias compared with boys born without hypospadias? Findings In this large multistate birth defects registry cohort study of data from population-based birth defect surveillance programs on all male infants born in 11 US states, boys born with hypospadias were 6 times more likely than boys without hypospadias to have any major congenital heart defect. Meaning This study suggests that screenings for additional birth defects among boys born with hypospadias may be warranted; in addition, molecular studies are needed to uncover the shared etiology of co-occurring defects in different developmental fields.

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“…The controls were matched to the cases by birth year at a ratio of 10:1 controls to cases with a total of 8,981 hypospadias cases and 89,810 control cases in the study group. Ten controls per case was selected based on the assessment by Langlois et al, which demonstrated the effect estimates were similar to using an entire birth cohort in the state of Texas (Langlois, Canfield, & Swartz, 2013). The Texas Department of State Health Services and Baylor College of Medicine Institutional Review Board approved the study protocol.…”

Section: Methodsmentioning

confidence: 99%

Hypospadias risk is increased with maternal residential exposure to hormonally active hazardous air pollutants

Sheth

Kovar

White

et al. 2019

Birth Defects Research

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Background: With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and the Texas Birth Defects Registry (TBDR). Methods: Using the TBDR, we identified 8,981 nonsyndromic isolated hypospadias cases from 1999 to 2008. Birth certificate controls were matched for birth year at a 10:1 ratio to cases. Estimated HAHAP concentrations from the 2005 U.S. EPA National–Scale Air Toxics Assessment were used to assign exposure based on maternal residence at birth. Exposure levels were categorized as quintiles based on the distribution in controls. Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for each increasing exposure category of selected HAHAPs. Results: Of the 10 HAHAPs studied, seven were significantly associated with hypospadias risk. The HAHAP that was most strongly associated with hypospadias was phenol, which was associated with risk in all groups except the high exposure group. Cumulative HAHAP exposure demonstrated a modest increase in hypospadias risk (OR 1.15, 95% CI: 1.07–1.24, p < 0.001) in the medium and medium–high quintiles. Conclusions: While maternal exposure to some HAHAPs was significantly associated with the risk of hypospadias in male offspring, the effects were modest, and no dose–response effects were observed. Future work should employ biomarkers of exposure to better delineate the relationship.

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Poisson versus logistic regression in a descriptive epidemiologic analysis of data from a Birth Defects Registry

Abstract: For these descriptive epidemiologic analyses, PR yielded the most precise estimates. However, LR provided similar estimates, and using 10 controls per case yielded precision almost as good as PR.

Cited by 7 publications

References 14 publications

Diabetes mellitus and its impact on mortality rate and outcome in pulmonary embolism

Diabetes mellitus and its impact on mortality rate and outcome in pulmonary embolism

Prevalence and Clustering of Congenital Heart Defects Among Boys With Hypospadias

Hypospadias risk is increased with maternal residential exposure to hormonally active hazardous air pollutants

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