Epidemiology and Etiology of Young Stroke

Griffiths, Dayna; Sturm, Jonathan

doi:10.4061/2011/209370

Cited by 112 publications

(125 citation statements)

References 123 publications

(214 reference statements)

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“…The same was confirmed in our study, where among other causes arterial dissection and APLAS were also recorded. Small artery occlusion in younger stroke patients is usually associated with tobacco smoking 16 , which corresponded to the proportion of small artery occlusion in our patients and the proportion of smokers in our young patient group (almost half of all patients). This may also be the explanation for the slightly more frequent posterior territory affection.…”

Section: Discussionmentioning

confidence: 99%

“…Similar percentages were revealed in our study and further corroborated by our CDFI findings of a higher carotid atherosclerosis incidence in men. On the other hand, in young stroke patients, the etiology differs following this order of significance: cardioembolism, arterial dissection, migraine, drug use, use of oral contraceptives (OC), antiphospholipid syndrome (APLAS), inherited coagulation disorders and rare causes of non-atherosclerotic arteriopathies, which combined comprise about one-third of all cases [16][17][18] . The same was confirmed in our study, where among other causes arterial dissection and APLAS were also recorded.…”

Section: Discussionmentioning

confidence: 99%

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Age and Gender Differences in Acute Stroke Hospital Patients

Kes¹,

Jurašić²,

Zavoreo³

et al. 2016

ACC

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SUMMARY -Stroke is the second leading cause of death and the most important cause of adult disability worldwide and in Croatia. In the past, stroke was almost exclusively considered to be a disease of the elderly; however, today the age limit has considerably lowered towards younger age. The aim of this study was to determine age and gender impact on stroke patients in a Croatian urban area during one-year survey. The study included all acute stroke patients admitted to our Department in 2004. A compiled stroke questionnaire was fulfilled during hospitalization by medical personnel on the following items: stroke risk factors including lifestyle habits (smoking and alcohol), pre-stroke physical ability evaluation, stroke evolution data, laboratory and computed tomography findings, outcome data and post-stroke disability assessment. Appropriate statistical analysis of numerical and categorical data was performed at the level of p<0.05. Analysis was performed on 396 patients, 24 of them from the younger adult stroke group. Older stroke patients had worse disability at hospital discharge and women had worse disabilities at both stroke onset and hospital discharge, probably due to older age at stroke onset. Younger patients recovered better, while older patients had to seek secondary medical facilities more often, as expected. The most important in-hospital laboratory findings in young stroke patients were elevated lipid levels, while older patients had elevated serum glucose and C-reactive protein. Stroke onset in younger patients most often presented with sudden onset headache; additionally, onset seizure was observed more frequently than expected. Stroke risk factor analysis showed that women were more prone to hypertension, chronic heart failure and atrial fibrillation, whereas men had carotid disease more frequently, were more often smokers and had higher alcohol intake. Additionally, age analysis showed that heart conditions and smoking were more prevalent among older stroke patients. In conclusion, considerable differences were established between age and gender stroke patient groups, confirming the need of permanent national stroke registry and subsequent targeted action in secondary care, and prevention with education on risk factors, preferably personally tailored.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Age and Gender Differences in Acute Stroke Hospital Patients

Kes¹,

Jurašić²,

Zavoreo³

et al. 2016

ACC

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“…36 Among other components, the cardiometabolic syndrome can be associated with hypercoagulability and mediated by inflammatory response and interferences in the coagulation process, which may contribute to increased risk for cardiovascular events. 37 Atrial fibrillation, a common cause for cerebral emboli 38 is believed to be under diagnosed in patients with stroke of undetermined cause.…”

Section: Stroke In the Youngmentioning

confidence: 99%

Air Pollution and Ischemic Stroke Among Young Adults

Yitshak‐Sade

Novack

Ifergane

et al. 2015

Stroke

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We have recently presented a new method of assessing spatiotemporal resolved PM 2.5 and PM 10 exposures 18,19 in the Negev (South Israel)-a semi-arid area, located in the global dust belt, which extends from West Africa to the Arabian Desert. 20 Unlike many commonly used exposure models, our model makes use of satellite aerosol optical depth measurements, which allowed us to estimate daily, spatially resolved, PM 10 and PM 2.5 concentration with the inclusion of populations in rural areas not living nearby monitoring stations.Stroke in older patients is mostly related to atherosclerosis. 21 In the young, however, stroke is less common, and the cause is much more diverse and often unexplained. 21 We hypothesize that PM exposure is positively associated with stroke, especially among young adults. Methods Study PopulationWe included all Clalit Health Services members with available geocoded addresses in Southern Israel, admitted to Soroka University Medical Center (SUMC) with hemorrhagic (International Classification of Diseases Ninth Revision [ICD9] 430-432) or ischemic stroke (ICD9 432-435) between the years 2005 and 2012. SUMC is the only medical center providing acute neurological care in the area, serving a population of ≈1 million residents; therefore, all the patients with stroke are referred to SUMC. Clalit Health Service is the largest health care provider in the area, covering ≈70% of the population. To avoid within subject correlation among recurrent events, we used only the first stroke event, within the study period, for each subject. 22Background and Purpose-Studies have demonstrated consistent associations between cardiovascular illness and particulate matter (PM) <10 and <2.5 μm in diameter, but stroke received less attention. We hypothesized that air pollution, an inflammation progenitor, can be associated with stroke incidence in young patients in whom the usual risk factors for stroke are less prevalent. We aimed to evaluate the association between stroke incidence and exposure to PM <10 and <2.5 μm, in a desert area characterized by a wide range of PM. Methods-We included all members of the largest health maintenance organization in Israel, who were admitted to a local hospital with stroke between 2005 and 2012. Exposure assessment was based on a hybrid model incorporating daily satellite remote sensing data at 1-km spatial resolution. We performed case-crossover analysis, stratified by personal characteristics and distance from main roads.

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“…6 The rate of stroke in this group also overlaps the overall incidence rate described for subjects under the age of 45. 30,31 A cohort study showed that women who experience recurrent spontaneous pregnancy loss or stillbirth are not at higher risk of stroke later in life. 32 We were able to rely heavily on the Nîmes Obstetricans and Haematologist (NOHA) administrative region hospital medical network.…”

Section: Thrombosis In Obstetrical Aps 2629mentioning

confidence: 99%

Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study

Gris

Bouvier

Molinari³

et al. 2012

Blood

100

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The incidence of thrombosis in the purely obstetric form of antiphospholipid syndrome is uncertain. We performed a 10-year observational study of 1592 nonthrombotic women who had experienced 3 consecutive spontaneous abortions before the 10th week of gestation or 1 fetal death at or beyond the 10th week of gestation. We compared the frequencies of thrombotic events among women positive for antiphospholipid Abs (n ‫؍‬ 517), women carrying the F5 6025 or

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Epidemiology and Etiology of Young Stroke

Cited by 112 publications

References 123 publications

Age and Gender Differences in Acute Stroke Hospital Patients

Age and Gender Differences in Acute Stroke Hospital Patients

Air Pollution and Ischemic Stroke Among Young Adults

Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study

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