Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study

Abstract

The incidence of thrombosis in the purely obstetric form of antiphospholipid syndrome is uncertain. We performed a 10-year observational study of 1592 nonthrombotic women who had experienced 3 consecutive spontaneous abortions before the 10th week of gestation or 1 fetal death at or beyond the 10th week of gestation. We compared the frequencies of thrombotic events among women positive for antiphospholipid Abs (n ‫؍‬ 517), women carrying the F5 6025 or

Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study

“…It received substantial support from the Nîmes Obstetricians and Haematologists (NOHA) administrative region-hospital medical network, 31 which was able to recruit a substantial number of patients. 9 New pregnancies were observed after inclusion, and there was no loss to follow-up, in part because of the relatively short lengths of time between screening/ inclusion and the new pregnancies. Pregnancy outcomes were objectively diagnosed using guidelines and international criteria/ definitions.…”

“…9 Women were classified as hypertensive if they were using hypertensive medication or had either a systolic blood pressure of $140 mm Hg or a diastolic blood pressure of $90 mm Hg, both on 2 readings taken in a supine position 5 minutes apart, and on 2 separate occasions. PE was defined as the diastolic blood pressure increasing to .90 mm Hg, or systolic blood pressure increasing to .140 mm Hg on 2 occasions at least 4 hours apart after 20 WG, accompanied by a significant proteinuria (.0.3 g in a 24-hour urine sample).…”

“…The Nîmes Obstetricians and Hematologists Antiphospholipid Syndrome (NOH-APS) study 9 prospectively recorded the frequencies of pregnancy outcomes among women with no history of thrombosis who had experienced pregnancy loss fulfilling the clinical criteria for APS and who were either positive for aPLAbs (APS group) or negative for aPLAbs (control group).…”

“…infra). 9,10 Women with antithrombin, protein C, or protein S deficiency, and women with an abnormal fibrinogen or the JAK2 V617F mutation were not included. Women with completely negative thrombophilia screening results (N 5 3741) and who agreed to participate in the observational study (n 5 3604) were provisionally assigned to the "negative" group and were numbered according to the order in which they entered the study.…”

Equal-opportunity treatment of EBV-PTLD

“…1 In this issue of Blood, the group updates their experience in treating PTLD from 1991 to 2009, using DLI, donorspecific, and third-party EBV-specific cytotoxic T cell lines (CTLs). 2 T heir comprehensive review of 49 patients provides important information about response rates and kinetics, confirming that even CTLs that are MHC mismatched with the recipient are not alloreactive.…”