Epidemiology and clinical manifestations of children with macrolide-resistant Mycoplasma pneumoniae pneumonia in Southern Taiwan

Abstract

Background: Mycoplasma pneumoniae is a pneumonia-causing pathogen commonly found in pediatric patients in Taiwan. Recently, macrolide-resistant (MR) strains have been emerging globally. The prevalence of pneumonia due to MR-M. pneumoniae (hereafter, MPP) in northern Taiwan before 2017 has been reported to be 12.3e24%. The prevalence of MR-MPP within a specific location can vary. Hence, we investigated the prevalence of MR-MPP in southern Taiwan.Methods: Eighty-one children with PCR-confirmed MPP were enrolled between July 2016 and June 2019. They were assigned to macrolide-sensitive (MS) and MR groups based on their PCR results, and their clinical manifestations and laboratory data were compared. Results: The proportions of patients with MS-MPP and MR-MPP varied with time. The average ratio of the proportion of MR-MPP was 54.3% in this study. Patients with MR-MPP had lower neutrophil counts, higher lymphocyte counts, and higher platelet counts than those with MS-MPP. In contrast with the 40% of the MR-MPP group that still had a fever after three days of azithromycin treatment, only 11.8% of the MS-MPP group still had a fever. Conclusion: Our study provided valuable epidemiological survey information for children with

Predictive value of bronchoscopy combined with CT score for refractory mycoplasma pneumoniae pneumonia in children

“…The mycoplasma pneumoniae sequence numbers showed no statistical significance in the first two groups, while the correlation analysis in the RMPP group also yielded no substantial results. This outcome may be linked to the rising incidence of mycoplasma pneumoniae resistance mutations [ 25 ], although it should be noted that the number of cases in this study was relatively small.…”

Clinical significance of Mycoplasma pneumoniae specific IgM titer in children hospitalized with Mycoplasma pneumoniae pneumonia

“…In terms of responses to stepwise treatment for MP pneumonia, the proportion of poor response, defined as a combination of slow response, no response, and progression, was higher with a significantly increasing trend in children with positive MP-specific IgM titers, compared with those with negative MP-specific IgM titers. There are some debates on whether macrolide resistance of MP may affect the response to the stepwise treatment for MP pneumonia [ 23 – 25 ] and there have been no studies on the effects of macrolide resistance of MP on MP-specific IgM titer in MP pneumonia. In the present study, there was no significant association between response to the stepwise treatment in MP pneumonia and positive MP-specific IgM titers, even when the macrolide resistance of MP was adjusted with age, sex, and duration between symptom onset and performance date of MP-specific IgM test.…”

Recent Trends in the Epidemiology, Diagnosis, and Treatment of Macrolide-Resistant Mycoplasma pneumoniae

“…Mycoplasma pneumoniae (MP) is a major pathogen that causes lower respiratory tract infections, such as pneumonia [ 1 ], which might lead to extra-pulmonary diseases [ 2 ]. Among MPs, there has been an increase in macrolide-resistant Mycoplasma pneumoniae (MRMP), which has become a problem, especially in East Asian countries [ 3 , 4 , 5 ]. There are varying MRMP rates among countries.…”