Epidemiologie und Therapie der behandlungsbedürftigen Frühgeborenenretinopathie. Die Hannoveraner Daten im Retina.net ROP-Register von 2001 bis 2017

Akman, S.; Pfeil, Johanna M.; Stahl, Andreas; Ehlers, Stephanie; Böhne, Carolin; Bohnhorst, Bettina; Framme, Carsten; Brockmann, Dorothee; Bajor, Anna; Jacobsen, Christina; Hufendiek, Karsten; Pielen, Amelie; Behrens, Julia; Luger, Benjamin; Mies, Sophia; Wojtera, Nora; Zirkler, Carina; Register-Studiengruppe, Retina.net Rop

doi:10.1007/s00347-021-01528-9

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…For example, in England, there are Bristol Eye Hospital (individual) [25], NHS operational data (161 medical units), the British Ophthalmic Surveillance Unit, and a national collaborative ROP special interest groups (327 groups) (multiple) [26,27]. In Germany, there are Bonn/Freiburg cohort ROP Registry [28], a single medical center in Hannover (individual) [29], ROP Registry, and the IQTIG database (multiple) [28]. In Poland, there are Adam Mickiewicz Medical University Hospital in Poznan, two large regions of Poland (individual) [30], and the GOCC database (multiple) [31].…”

Section: Resultsmentioning

confidence: 99%

“…Larsen et al [28] German national guideline on ROP screening [34] GA < 32 weeks, or if GA is unknown, birth weight ≤1500 g or GA < 37 weeks and > 3 days of oxygen supplementation Larsen et al [28] Larsen et al [28] Akman et al [29] New German guidelines [35,36] GA < 31 + 0 If there is risk factors, such as over 5 days oxygen administration, ECMO usage, severe NEC, BPD, sepsis, or transfusion-requiring anemia…”

Section: Germanymentioning

confidence: 99%

“…Another study covering a wider range of years (2001-2017) is that of Akman et al [29], from a single medical center in Hannover, which created the aforementioned retina.net ROP Registry database. It showed that ROP was diagnosed during the screening of 864 premature infants in the period of 2001-2017, and the proportion of premature infants requiring treatment was 7.5%.…”

Section: Germanymentioning

confidence: 99%

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Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Modrzejewska

Bosy-Gąsior

2023

JCM

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Introduction: Global predictions indicate that the incidence of retinopathy of prematurity (ROP) is increasing, but the lack of current epidemiological data on the occurrence of ROP in Europe prompted the authors to update these data. Methods: European studies related to the presence of ROP were analyzed, and the reason for the differences in the percentage of ROP and different screening criteria were checked. Results: The study presents results from individual and multiple centers. Current ROP incidence data varies from a low of 9.3% in Switzerland to the highest values of 64.1% in Portugal and 39.5% in Norway. The national screening criteria are used in the Netherlands, Germany, Norway, Poland, Portugal, Switzerland, and Sweden. Uniform criteria—Royal College of Paediatrics and Child Health guidelines are used in England and Greece. American Academy of Pediatrics screening guidelines are used in France and Italy. Conclusions: The epidemiology of ROP in European countries varies significantly. The increase in the diagnosis and treatment rate of ROP in recent years correlates with the narrowing of diagnostic criteria in newly issued guidelines (which include the WINROP and G-ROP algorithms), a higher number of less developed preterm infants, and a lower percentage of live births.

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Section: Resultsmentioning

confidence: 99%

Section: Germanymentioning

confidence: 99%

Section: Germanymentioning

confidence: 99%

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Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Modrzejewska

Bosy-Gąsior

2023

JCM

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“…A p-value of ≤0.05 was considered statistically significant. Some of the data from the Retina.net ROP registry presented here have been published in previous analyses (Akman et al, 2022;Larsen et al, 2021;Retina.net ROP-Register-Studiengruppe et al, 2018;Walz et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Comparability of input parameters in the German Retina.net ROP registry and the EU‐ROP registry – An exemplary comparison between 2011 and 2021

Winter,

Pfeil,

Engmann

et al. 2023

Acta Ophthalmologica

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PurposeThe German Retina.net ROP registry and its Europe‐wide successor, the EU‐ROP registry, collect data from patients treated for ROP. This analysis compares input parameters of these two registries to establish a procedure for joint analyses of different registry data using exemplary datasets from the two registries.MethodsExemplary datasets from the two databases over a 1‐year period each (German Retina.net ROP Registry, 2011, 22 infants; EU‐ROP Registry, 2021, 44 infants) were compared. The parameters documented in the two databases were aligned and analysed regarding demographic parameters, treatment modalities, complications within first 24 h and retreatments.ResultsThe current analysis showed that data can be aligned for joint analyses with some adjustments within the data structure. The registry with more detailed data collection (EU‐ROP) needs to be reduced regarding granularity in order to align the different registries, as the registry with lower granularity determines the level of analyses that can be performed in a comparative approach. In the exemplary datasets, we observed that the overall most common ROP severity in both registries was zone II, 3+ (2011: 70.5%; 2021: 65%), with decreasing numbers of clock hours showing preretinal neovascularisations (2011: 10–12 clock hours in 29% of cases, 2021: 4–6 clock hours in 38%). The most prevalent treatment method was laser coagulation in 2011 (75%) and anti‐VEGF therapy in 2021 (86.1%). Within the anti‐VEGF group, all patients were treated with bevacizumab in 2011 and with ranibizumab in 2021. Retreatment rates were comparable in 2011 and 2021.ConclusionData from two different ROP registries can be aligned and jointly analysed. The analysis reveals a paradigm shift in treatment modalities, from predominantly laser to anti‐VEGF, and within the anti‐VEGF group from bevacizumab to ranibizumab in Germany. In addition, there was a trend towards earlier treatment in 2021.

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Frühgeborenenretinopathie

Stahl,

Pfeil

2023

Springer Reference Medizin

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Epidemiologie und Therapie der behandlungsbedürftigen Frühgeborenenretinopathie. Die Hannoveraner Daten im Retina.net ROP-Register von 2001 bis 2017

Cited by 5 publications

References 17 publications

Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Comparability of input parameters in the German Retina.net ROP registry and the EU‐ROP registry – An exemplary comparison between 2011 and 2021

Frühgeborenenretinopathie

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