Epidemiologie der Myopie

Hopf, Susanne; Pfeiffer, Norbert

doi:10.1007/s00347-016-0361-2

Cited by 41 publications

(36 citation statements)

References 26 publications

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“…High myopia-associated complications such as retinal detachment, macular lesions, peripapillary deformation and myopia choroidal neovascularization may lead to severe and irreversible visual loss [ 11 ]. Related complications of high myopia will become one of the main causes of visual impairment in the next few decades in the world [ 12 , 13 ]. Jung et al reported that the prevalence of high myopia was 21.6% in 19-year-old males in Seoul in 2010 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The increasing prevalence of myopia and high myopia among high school students in Fenghua city, eastern China: a 15-year population-based survey

Wu²,

et al. 2018

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BackgroundMyopia is the leading cause of preventable blindness in children and young adults. Multiple epidemiological studies have confirmed a high prevalence of myopia in Asian countries. However, fewer longitudinal studies have been performed to evaluate the secular changes in the prevalence of myopia, especially high myopia in China. In the present study, we investigated trends in the prevalence of myopia among high school students in Fenghua city, eastern China, from 2001 to 2015.MethodsThis was a population-based, retrospective study. Data were collected among 43,858 third-year high school students. Noncycloplegic autorefraction was used to determine refractive error, which was defined as low myopia, moderate myopia, high myopia and very high myopia according to the spherical equivalent from the worse eye of each participant. The prevalence of myopia was calculated and the annual percentage change (APC) was used to quantify the time trends. All analyses were conducted using the SPSS, Stata and Graphpad Prism software.ResultsFrom 2001 to 2015, the prevalence of overall myopia increased from 79.5% to 87.7% (APC =0.59%), with a significant increase of moderate myopia (38.8% to 45.7%, APC = 0.78%), high myopia (7.9% to 16.6%, APC = 5.48%) and very high myopia (0.08% to 0.92%, APC = 14.59%), while the prevalence of low myopia decreased from 32.7% to 24.4% (APC = − 1.73%). High myopia and very high myopia contributed the major part of the increasing trend of myopia prevalence (contribution rate 27.00% and 69.07%, respectively).ConclusionsDuring the 15-year period, there was a remarkable increase in the prevalence of high and very high myopia among high school students, which might become a serious public health problem in China for the next few decades.Electronic supplementary materialThe online version of this article (10.1186/s12886-018-0829-8) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The increasing prevalence of myopia and high myopia among high school students in Fenghua city, eastern China: a 15-year population-based survey

Wu²,

et al. 2018

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“…Myopia is a type of refractive error that is mainly determined by corneal curvature, lens adjustment and axial length [1]. Myopia is prevalent worldwide, at approximately 28.3% [2]. Furthermore, the situation is severe in East Asia, especially among students and young adults, with a prevalence of almost 90% [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Myopia is prevalent worldwide, at approximately 28.3% [2]. Furthermore, the situation is severe in East Asia, especially among students and young adults, with a prevalence of almost 90% [2][3][4][5][6][7][8][9]. A recent meta-analysis showed that the number of patients with myopia worldwide has increased from 1406 million in 2000 to 1950 million in 2010; it is predicted that the number of myopia patients will reach 4758 million by 2050 [10].…”

Section: Introductionmentioning

confidence: 99%

Association of 5p15.2 and 15q14 with High Myopia in Tujia and Miao Chinese Populations

Wang

Liu

Song

et al. 2020

Preprint

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Background: The polymorphisms rs6885224 and rs634990 have been reported to be associated with high myopia in many populations. As there is still no report on whether these two SNPs are associated with myopia in the Tujia and Miao minority areas of China, we conducted a replication study to evaluate the association of single-nucleotide polymorphisms in the regions 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese populations.Methods: We performed a comprehensive meta-analysis of 5831 cases and 7055 controls to assess whether rs6885224 in the 5p15.2 region and rs634990 in the 15q14 region are associated with high myopia. Our replication study enrolled 804 individuals. Genomic DNA was extracted from venous leukocytes, and these two SNPs were genotyped by Sanger sequencing. Allele and genotype frequencies were analysed using χ2 tests, and ORs and 95% CIs were calculated.Results: According to the results of the meta-analysis, rs6885224 in the CTNND2 gene showed no association with myopia [p=0.222, OR=1.154, 95% CI (0.917-1.452)]. Conversely, rs634990 in the 15q14 region did exhibit a significant correlation with myopia [p=7.270´10-7, OR=0.817, 95% CI (0.754-0.885)]. In our replication study, no association with high myopia in the Tujia and Miao populations was found for rs634990 or rs6885224. The following were obtained by allele frequency analysis: rs6885224, p=0.175, OR=0.845, and 95% CI=0.662-1.078; rs634990, p=0.087, OR=0.84, and the 95% CI=0.687-1.026. Genotype frequency analysis yielded p=0.376 for rs6885224 and p=0.243 for rs634990.Conclusions: Our meta-analysis results show that rs634990 was significantly associated with myopia but that rs6885224 was not. Nevertheless, in our replication study, these two SNPs showed no association with myopia in the Tujia and Miao Chinese populations. This is the first report involving Tujia and Miao ethnic groups from Enshi minority areas. However, the sample size needs to be expanded and more stringent inclusion and exclusion criteria need to be formulated to verify the findings.

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“…In the year 2000, the prevalence of high myopia was about 2.7% of the world population (163 million people) and it is predicted that by 2050 there will be about 938 million people suffering from high myopia (9.8% of the world population) [1]. High myopia may result in irreversible visual loss due to the retinal detachment, choroidal neovascularization, macular atrophy, glaucoma, cataract and other complications [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Results of pars plana vitrectomy for primary rhegmatogenous retinal detachment with PVR grades A and B in high-myopic eyes

et al. 2019

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Purpose To evaluate the results of pars plana vitrectomy (PPV) without adjuvant buckling procedures for the primary rhegmatogenous retinal detachment (RRD) with PVR grades A and B in high-myopic eyes. Methods A retrospective review included 291 eyes treated for primary RRD from 2008 to 2016. The single surgery success rate (SSSR), the total number of surgeries, outcomes and complications were analysed between group of 67 eyes with high axial myopia (group A) and group of 224 eyes without high myopia (group B). Results The mean follow-up was 30.6 ± 22.8 months. The SSSR in group A was 82.1% and in group B was 86.2% (p [ 0.05). The final reattachment rate and number of required surgeries were in group A 96.3% (3.1 surgeries) and in group B 96.0% (2.8 surgeries). The initial BCVA improved in group A from 1.58 to 0.58 LogMAR at year 3; and in group B from 1.21 to 0.34 LogMAR. In match-pair analysis of macula-off RRD, no significant difference of the CRT between groups A and B was observed within 3 years of follow-up. Conclusion The anatomical success of primary PPV for RRD did not differ between high-myopic and nonhigh-myopic eyes in PVR grades A and B. However, functional results of high-myopic eyes are worse compared to eyes without high axial myopia.

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Epidemiologie der Myopie

Abstract: Myopia is already a ubiquitous phenomenon in some parts of the world. One out of ten persons will be at a relevant risk of becoming blind as a result of myopia in the future. Preventive measures have not shown sweeping success.

Cited by 41 publications

References 26 publications

The increasing prevalence of myopia and high myopia among high school students in Fenghua city, eastern China: a 15-year population-based survey

The increasing prevalence of myopia and high myopia among high school students in Fenghua city, eastern China: a 15-year population-based survey

Association of 5p15.2 and 15q14 with High Myopia in Tujia and Miao Chinese Populations

Results of pars plana vitrectomy for primary rhegmatogenous retinal detachment with PVR grades A and B in high-myopic eyes

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