“…Although these studies have resulted in improved prediction of PD and a decrease in the number of premature births, at present, the accuracy of predicting preterm births is still a puzzle because of many factors that contribute to the outcome of PD. These factors include a previous history of PD, gestational age, pregnancy complications, psychological and genetic factors 7 , maternal obesity 8 , 9 , placenta previa 10 , fat-to-placenta strain ratio value 11 , serum relaxin 12 , insulin-like growth factor-binding protein-1 13 , interleukin-1β (IL-1β) 14 , thioredoxin and interleukin 1 receptor antagonist 15 , and fetal fibronectin levels and cervical length measurements 16 , 17 . However, some of these factors have shortcomings with respect to sensitivity or specificity, which affects the accuracy of PD prediction.…”