Epidemiological Trends of Histopathologically WHO Classified CNS Tumors in Developing Countries: Systematic Review

Khan, Ishaq N.; Bangash, Mohammed; Baeesa, Saleh; Jamal, Awatif; Carracedo, Ángel; Alghamdi, Fahad; Qashqari, Hanadi; Abuzenadah, Adel M.; Alqahtani, Mohammed Saad; Damanhouri, Ghazi A.; Chaudhary, Adeel; Hussein, Deema

doi:10.7314/apjcp.2015.16.1.205

Cited by 12 publications

(6 citation statements)

References 139 publications

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“…In Japan, Nakamura, et al, 17 reported a comprehensible prevalence of meningiomas of 38.2% [17][18][19][20] . From Latin America the only report was the study by Ramos Clason et al, 21 . This study performed in Colombia, and reviewed a total of 390 cases, meningiomas were the most common 50%.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of CNS Tumors and Histological Recognition in the Operated Patients: 10 Years Experience in Yemen

2021

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Background: Tumors of the central nervous system consist of a heterogeneous grouping of neoplasms of enormous histological variety. In spite of the increasing prevalence of CNS tumors in developing countries, certain places alike Yemen do not have representative studies showing the true impact of these tumors on the population. Aims: Description of the distinctiveness of primary and secondary tumors of the CNS in the past ten years in one Yemeni institute. Subjects and methods: A descriptive-observational study was performed on patients with tumors of the CNS who were selectively treated by surgical excision with subsequent diagnosis through a study of pathological tissues at the Saudi German Hospital SGH- Sana'a, over a period of 10 years from January 1, 2009 to December 31, 2019. The variables of the study were qualitative (histological type, gender, affected anatomical position) and quantitative (age). Both group and histopathological diagnoses were formed in line with the 2006 WHO classification of CNS tumors. Results: There were a total of 359 central nervous system tumors. Of these, 200 were females and 159 were males, with a ratio of 1.3: 1 and a mean age of 49.3 years. The most common tumors were the neuroepithelium (28.4%), meningiomas (26.55%), followed by mesenchymal tumors (13.4%), sellar region tumors (11.14%) and the nerve sheets tumors (11.14%). Meningiomas had the highest prevalence in female patients (20.33%), while it was in male neuroepithelial tumors (15.32%). Single entity repeat point form, Grade I meningioma was the most common (18.11%) followed by pituitary adenomas (9.2%), Glioblastoma multiform (8.6%), Class II meningiomas (7.24%) and Schwannoma (6.7%). Conclusion: This is the firstly study of a sequence of cases in Yemen to be conducted on both benign and malignant tumors of the CNS, with all age groups patients with a extent of 10 years. Whilst this work represents no more than a retrospective analysis of a single institute, it can be a strong indicator of the epidemiology of the CNS tumors in Yemen. Peer Review History: Received 12 March 2021; Revised 26 March; Accepted 22 April, Available online 15 May 2021 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com Dr. Ahmed Mohammed Al-Haddad, Hadhramout University, Al-Mukalla, Yemen, ahmedalhaddad@yahoo.com

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Section: Discussionmentioning

confidence: 99%

Prevalence of CNS Tumors and Histological Recognition in the Operated Patients: 10 Years Experience in Yemen

2021

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“…A systematic review by Khan et al showed that inadequate reporting of CNS tumor subtypes was observed in registries of developing countries [21]. They suggested establishing a unified reporting system to help improve health management for CNS tumors [16].…”

Section: Discussionmentioning

confidence: 99%

The Epidemiology of Primary Central Nervous System Tumors at the National Neurologic Institute in Saudi Arabia: A Ten-Year Single-Institution Study

Al-Mutrafi

Bashawry

Al-Shakweer

et al. 2020

Journal of Cancer Epidemiology

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with a diagnosis of primary CNS tumor (brain and spinal cord) were selected. Data about sex, age, tumor location, and histologic type were collected. The classification was based on the International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3). Results. Nine hundred and ninety-two (992) cases of primary CNS tumors throughout the ten years (2005 to 2014) were reviewed. There were 714 (71.97%) adults and 278 (28.02%) in the pediatric age group. Nonmalignant tumors dominated the adult population (60.08%) while malignant tumors were more frequent in the pediatric population. Gliomas constituted the most common neoplastic category in children and adults. The most common single tumor entity was meningioma (26.99%, ICD-O-3 histology codes 9530/0, 9539/1, and 9530/3). Medulloblastomas (ICD-O-3 histology codes 9470, 9471, and 9474) were the most common single tumor entity in the pediatric age group (26.62%). Conclusions. This is an institution-based, detailed, and descriptive epidemiological study of patients with primary CNS tumors in Saudi Arabia. In contrast to other regional and international studies, the medulloblastomas in our institution are more frequent than pilocytic astrocytomas. Limitations to our study included the referral bias and histology-based methodology.

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“…They account for the most World Health Organization (WHO) classified Central Nervous System (CNS) tumors in the USA [2], and are highly reported worldwide [3]. WHO classifies meningiomas into fifteen variants with grade I–III.…”

Section: Introductionmentioning

confidence: 99%

Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines

et al. 2017

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BackgroundMeningioma tumors arise in arachnoid membranes, and are the most reported central nervous system (CNS) tumors worldwide. Up to 20% of grade I meningioma tumors reoccur and currently predictive cancer stem cells (CSCs) markers for aggressive and drug resistant meningiomas are scarce.MethodsMeningioma tissues and primary cell lines were investigated using whole transcriptome microarray analysis, immunofluorescence staining of CSCs markers (including CD133, Sox2, Nestin, and Frizzled 9), and drug treatment with cisplatin or etoposide.ResultsUnsupervised hierarchical clustering of six meningioma samples separated tissues into two groups. Analysis identified stem cells related pathways to be differential between the two groups and indicated the de-regulation of the stem cell associated genes Reelin (RELN), Calbindin 1 (CALB1) and Anterior Gradient 2 Homolog (AGR2). Immunofluorescence staining for four tissues confirmed stemness variation in situ. Biological characterization of fifteen meningioma primary cell lines concordantly separated cells into two functionally distinct sub-groups. Pleomorphic cell lines (NG type) grew significantly faster than monomorphic cell lines (G type), had a higher number of cells that express Ki67, and were able to migrate aggressively in vitro. In addition, NG type cell lines had a lower expression of nuclear Caspase-3, and had a significantly higher number of CSCs co-positive for CD133+ Sox2+ or AGR2+ BMI1+. Importantly, these cells were more tolerant to cisplatin and etoposide treatment, showed a lower level of nuclear Caspase-3 in treated cells and harbored drug resistant CSCs.ConclusionCollectively, analyses of tissues and primary cell lines revealed stem cell associated genes as potential targets for aggressive and drug resistant meningiomas.Electronic supplementary materialThe online version of this article (doi:10.1186/s12935-017-0441-7) contains supplementary material, which is available to authorized users.

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Epidemiological Trends of Histopathologically WHO Classified CNS Tumors in Developing Countries: Systematic Review

Cited by 12 publications

References 139 publications

Prevalence of CNS Tumors and Histological Recognition in the Operated Patients: 10 Years Experience in Yemen

Prevalence of CNS Tumors and Histological Recognition in the Operated Patients: 10 Years Experience in Yemen

The Epidemiology of Primary Central Nervous System Tumors at the National Neurologic Institute in Saudi Arabia: A Ten-Year Single-Institution Study

Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines

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