Background: Tumors of the central nervous system consist of a heterogeneous grouping of neoplasms of enormous histological variety. In spite of the increasing prevalence of CNS tumors in developing countries, certain places alike Yemen do not have representative studies showing the true impact of these tumors on the population.   Aims: Description of the distinctiveness of primary and secondary tumors of the CNS in the past ten years in one Yemeni institute.  Subjects and methods:  A descriptive-observational study was performed on patients with tumors of the CNS who were selectively treated by surgical excision with subsequent diagnosis through a study of pathological tissues at the Saudi German Hospital SGH- Sana'a, over a period of 10 years from January 1, 2009 to December 31, 2019. The variables of the study were qualitative (histological type, gender, affected anatomical position) and quantitative (age). Both group and histopathological diagnoses were formed in line with the 2006 WHO classification of CNS tumors. Results: There were a total of 359 central nervous system tumors. Of these, 200 were females and 159 were males, with a ratio of 1.3: 1 and a mean age of 49.3 years. The most common tumors were the neuroepithelium (28.4%), meningiomas (26.55%), followed by mesenchymal tumors (13.4%), sellar region tumors (11.14%) and the nerve sheets tumors (11.14%).   Meningiomas had the highest prevalence in female patients (20.33%), while it was in male neuroepithelial tumors (15.32%). Single entity repeat point form, Grade I meningioma was the most common (18.11%) followed by pituitary adenomas (9.2%), Glioblastoma multiform (8.6%), Class II meningiomas (7.24%) and Schwannoma  (6.7%).  Conclusion:  This is the firstly study of a sequence of cases in Yemen  to be conducted on both benign and malignant tumors of the CNS, with all age groups patients  with a extent of 10 years. Whilst this work represents no more than a retrospective analysis of a single institute, it can be a strong indicator of the epidemiology of the CNS tumors in Yemen.                    Peer Review History: Received 12 March 2021; Revised 26 March; Accepted 22 April, Available online 15 May 2021 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. George Zhu,  Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com Dr. Ahmed Mohammed Al-Haddad, Hadhramout University, Al-Mukalla, Yemen, ahmedalhaddad@yahoo.com

Background: Prophylactic extraction of the asymptomatic impacted third molar is routinely practiced in Europe and the United States. The justification for prophylactic extraction includes the need to reduce the risk of pathologic changes such as cysts and tumors.   Objectives: This study aimed to study the histological and radiological changes in the tooth follicles of upper and lower complete impacted 3rd molars -which appeared radiologically normal. Material and method: A prospective study included fifty patients aged 20 years and above who were referred to the Oral Surgery Clinic, Faculty of Dentistry, University of Sana'a. Patients had follicular space between (2.5mm -3mm) as measured by the panoramic X-ray. These teeth were removed surgically and the follicle was sent for histopathological examination. Results: Most histopathological changes were in dental follicles with a size of <2.5 mm (86%), and only 14% with 2.5 mm - 3 mm. There was statistical significance between the smallest size of dental follicles with the incidence of pathological histological changes indicating a high probability of developing neoplasm (p =0.008).  Of the 50 follicular patients, 28% showed HC, nine (64%) had ameloblastoma, four (29%) had a dentigerous cyst, and only one case (7%) had a multicalcified focus with islands of odontogenic epithelium. While 72% of the samples had normal follicles and non-specific chronic inflammatory cells. There is an association between female sex and pathological histological changes (12 females: 2 males, p =0.008), age group 21-25 years (93% HC), with mandibles (65% HC). Regarding angle and histopathological changes, 36% were vertical, 29% mesioangular, 14.2% horizontal and destioangular, and 7.1% buccoangular. Conclusion:  High incidence of HC occurred in patients with DF, and it was associated with smaller dental follicle size, most HC was ameloblastoma, followed by dentigerous cyst, while 72% of samples had normal follicles and non-specific chronic inflammatory cells. There is a correlation between female gender, younger age group, and jaw position with HC. Prophylactic extraction of the asymptomatic impacted third molar should be routinely practiced in Yemen, to reduce the risk of pathological changes, especially in females and younger age groups.                            Peer Review History: Received 11 January 2021; Revised 8 February; Accepted 28 February, Available online 15 March 2021 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com Dr. Alfonso Alexander Aguileral, University of Veracruz,  Mexico, aalexander_2000@yahoo.com   Similar Articles: RADIOGRAPHIC ASSESSMENT OF THE COURSE AND VISIBILITY OF THE MANDIBULAR CANAL BY PANORAMIC RADIOGRAPHY

Objective: To analyze the outcomes of neurosurgical treatment of dorsal spinal tuberculosis (TB) among Yemeni patients. Methods: Forty-three patients with histopathology-confirmed dorsal spinal TB, who had been admitted to Kuwait University Hospital of Sana’a University and the University of Science and Technology Hospital, Sana’a, were followed up for the outcomes of neurosurgical treatment in the period from Ott. 2009 to Oct. 2005. Data about the clinical presentation, radiologic findings and the outcomes of surgical treatment were recorded and analyzed. Results: Of patients undergoing neurosurgical treatment of dorsal spinal TB, 28 were males and 15 were females, with a mean age of 41.3 years (range: 18–70). Nearly a half of patients (50.6%) were farmers and 80% of patients were admitted to hospitals three months after the disease onset. All patients presented with back pain, while paraplegia/paraparesis and sensory impairment were reported in 81.4% and 87.4% of patients at presentation, respectively. Four patients (9.2 %) had cold abscesses and were treated by abscess drainage, while 90.8% of patients were treated by surgical decompression, debridement and posterior transpedicular fixation by screws and rods. Conclusions: The posterior approach for the treatment of spinal TB, with bilateral transpedicular access to anterior decompression together with posterior transpedicular fixation, has satisfactory outcomes regarding the clinical improvement and spinal stabilization among Yemeni patients.

Objective: To analyze the outcomes of neurosurgical treatment of dorsal spinal tuberculosis (TB) among Yemeni patients. Methods: Forty-three patients with histopathology-confirmed dorsal spinal TB, who had been admitted to Kuwait University Hospital of Sana’a University and the University of Science and Technology Hospital, Sana’a, were followed up for the outcomes of neurosurgical treatment in the period from Ott. 2009 to Oct. 2005. Data about the clinical presentation, radiologic findings and the outcomes of surgical treatment were recorded and analyzed. Results: Of patients undergoing neurosurgical treatment of dorsal spinal TB, 28 were males and 15 were females, with a mean age of 41.3 years (range: 18–70). Nearly a half of patients (50.6%) were farmers and 80% of patients were admitted to hospitals three months after the disease onset. All patients presented with back pain, while paraplegia/paraparesis and sensory impairment were reported in 81.4% and 87.4% of patients at presentation, respectively. Four patients (9.2 %) had cold abscesses and were treated by abscess drainage, while 90.8% of patients were treated by surgical decompression, debridement and posterior transpedicular fixation by screws and rods. Conclusions: The posterior approach for the treatment of spinal TB, with bilateral transpedicular access to anterior decompression together with posterior transpedicular fixation, has satisfactory outcomes regarding the clinical improvement and spinal stabilization among Yemeni patients.

Introduction: Leukemia is a heterogeneous group of hematological disorders that is made up of several diverse and biologically distinct subgroups. Leukemia is the 11th and10th most common cause of cancer morbidity and mortality worldwide, respectively. There are insufficient data on the prevalence and associated factors of leukemia in Yemen, particularly in the study area. Aims: This cross-sectional study aims to determine the prevalence of different types of leukemia and associated factors among children with leukemia in the pediatric cancer units of Al-Kuwait Hospital, Sana'a City. Materials and Methods: A cross-sectional study was conducted on children with leukemia who were treated selectively in the pediatric leukemia units of Kuwait University Hospital in Sana'a. Group diagnostics and histopathological diagnoses were formed in line with the French, American and British classifications of leukemia in children in the pediatric leukemia units, over a period of 5 years. Factors associated with become infected with leukemia that were studied included ages, gender, and regarding outcomes. The association of death and recovery with different age groups and leukemia types was also studied through rates and calculation of OR, CI, chi-square test and p values ​​through probability tables. Results: 244 leukemia patients were diagnosed, treated and followed; there was association of leukemia with younger age group; 50% were in the age group 1-5 years and with mean ± SD age= 6.44 ± 3.7 years. There was significant association with male gender (66.7%). There was non-significant association between high mortality and the 6-10 year age group [(8/78; 10.2%), with OR = 2.6, p = 0.060, and with the AML [(4/38; 10.5%), OR = 2.1)]. Considering, the cure rates association with ages, roughly there were similar cure rates occurred in the different age groups. Also, there was high cure rate in the JCM (2/3; 66%), with OR = 2.9. And with the CML (7/11; 63.6%; OR = 2.60. Conclusion: In the current study an association between leukemia and younger age group, with males was found. An association between high mortality and the 6-10 year age group, with AML was found. Also, there was no association between ages and cure rate but a high cure rate occurred with JCM and CML.