Epidemiological Trends of Head and Neck Cancer: A Population-Based Study

Abstract

Background. Over the past decades, lots of advance have occurred in the prevention, diagnosis, and treatment of head and neck cancer (HNC). However, the contemporaneous incidence and survival trends, on the basis of population-based registry, have not been reported. Methods. The HNC cancer cases were accessed from the Surveillance, Epidemiology, and End Results (SEER) database. The incidence trend was analyzed by joinpoint analysis, with the survival trend being analyzed by period analysis of relative survival rate (RSR) and Kaplan-Meier analyses. Cox regression analysis was performed to identify the prognostic factors for overall survival. Results. The general incidence trend of HNC increases slightly, with an average annual percentage change of 0.6%, along with five fluctuating segments. The improvement of net survival over the past decades was showed by increasing 60-month RSR, from 54.1% to 56.0% to 60.9% to 66.8%, which was further confirmed by Kaplan-Meier analyses. Moreover, disparities in incidence and survival patterns can be observed in different subgroups. Conclusion. A fluctuating incidence pattern and an ever-improving survival were observed in HNC over time.

Distribution of the head and neck surgical oncology workforce in the United States

“…Similarly, while Washington D.C. appears to be a high-density area, surgeons practicing there likely serve patients from Maryland and Virginia. Nebraska is the other state with the number of head and neck surgeons (11) in excess of the national average. Nebraska is neighboring two states (Wyoming and South Dakota), one with no head and neck surgeons and the other with a low number of practicing surgeons.…”

“…A recent study of the Surveillance, Epidemiology and End Results (SEER) database demonstrated that the incidence of head and neck cancer (excluding thyroid cancer) in the United States has fluctuated significantly over the past 20 years with a slight average annual percentage increase of 0.6%. 11 It is speculated that although traditional risk factors including tobacco and alcohol abuse have decreased among the population, stagnation in head and neck cancer rates may be attributable to widespread HPV prevalence. 12 Independent studies of thyroid cancer reveal that the incidence of thyroid cancer that was increasing for many years has been more steady in most recent years.…”

VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial

“…Head and neck squamous cell carcinoma (HNSCC) is the 6th most common type of cancer worldwide [1]. Of all head and neck cancers, approximately 30% originate from the larynx, resulting in 52000 newly diagnosed patients annually in Europe [2].…”

A Nomogram for Predicting the Risk of Bone Metastasis in Newly Diagnosed Head and Neck Cancer Patients: A Real-World Data Retrospective Cohort Study From SEER Database

“…There were approximately 932,000 new HNC patients worldwide in 2020, of which 467,000 patients had died ( Sung et al, 2021 ). Although in the past 40 years, with the continuous developments in detection and treatment technologies, the 5-years survival rate of HNC has grown from 54.1% to 66.8%, but it still cannot meet the needs of patients for a more extended survival period ( Guo et al, 2021 ). The incidence of distant metastases from HNC ranges from 8.9–13.8%, and distant metastases is one of the main challenges that restrict the successful treatment of HNC patients ( Lee et al, 2012 ; Duprez et al, 2017 ).…”