Epidemiological study of human herpesvirus-6 and human herpesvirus-7 in pityriasis rosea

Abstract

We conclude that HHV-7 and HHV-6 may play a part in some patients with PR, but that other causative agents may exist. Further analyses are needed to determine the causative agents of PR.

Pityriasis rosea Associated with Imatinib (STI571, Gleevec)

“…PR has been associated with human herpesviruses infection, namely, herpes virus 6 and herpes virus 7 are implicated [1, 3, 4]. However, PR occurring as a drug reaction following administration of drugs or exposure to chemicals is also reported: gold salts [5], benflurafine [6], terbinafine [7], omeprazole [8], and metronidazole [9], as well as several vaccines (HBV [10], BCG), are reported as potential causative or contributing factors for PR appearing.…”

“…The eruption tends to occur on the trunk, it is moderately pruritic and lasts 3–8 weeks. As far as the causative agent(s), several factors are discussed, namely viruses [1], chemicals and drugs [2]. …”

Dermatological Skin Diseases Associated with Human Herpes Viruses 6, 7 and 8: Review

“…Yapılan çalış-malarda, lezyonlu deri, periferik kan ve dokuda HHV-6 araştırılmış ve çelişkili sonuçlar alınmış-tır. [15][16][17][18][19] Watanabe ve ark. pitriyazis rosealı hastaların lezyonlu deri, sağlam deri, tükürük ve kan örneklerinde virüsü araştırmış, sistemik aktif HHV-6 enfeksiyonunun pitriyazis rosea etiyolojisinde rol oynayabileceğini öne sürmüşlerdir.…”

“…20 Diğer yayınlarda bu bulgu desteklenmemiştir. [16][17][18][19] Bu veriler nedeni ile de HHV-6'nın pitriazis rozea etiyolojisindeki fonksiyonu net olarak anlaşıla-mamıştır.…”

Human herpesvirus 6: molecular biology and clinical features

“…Other suggested but unproven disease associations for HHV-6 include progressive multifocal leukoencephalopathy, Bells palsy, influenza encephalopathy, drug-induced hypersensitivity syndrome, pityriasis rosea, fetal hydrops, Kikuchi's necrotizing lymphadenitis, lymphoproliferative disorders (including non-Hodgkin's lymphomas, Hodgkin's lymphoma, acute lymphoblastic leukaemia), oral carcinoma, cervical carcinomas and chronic fatigue syndrome (Levy, 1997;Caserta et al, 2001;Reeves et al, 2000;Pitkaranta et al, 2000;Sugaya et al, 2002;Suzuki et al, 1998;Kosuge et al, 2000;Ashshi et al, 2000;Daibata et al, 1999;Bandobashi et al, 1997;Pellett et al, 1992). Of relevance to the discussion of associations with cancer is the observation that HHV-6 can integrate into chromosomes and be passed on to an index case's offspring (Daibata et al, 1999).…”