Epidemiological profile of mycotic keratitis in a tertiary care center of eastern Odisha

Paty, Bimoch Projna; Dash, Pallabi; Mohapatra, Dharitri; Chayani, Nirupama

doi:10.4103/jdrntruhs.jdrntruhs_62_17

Cited by 13 publications

(16 citation statements)

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“…in South India. 19 Among the Aspergillus species, A. fumigatus was the most prevalent species in our study, as also seen by Sanjeev H et al from Mangalore; at the same time, Punia RS et al and Tilak R et al found A. flavus to be the commonest. 20 These findings suggest that although Aspergillus spp is the most common isolate, some variation may be possible.…”

Section: Discussionsupporting

confidence: 88%

A prospective study to determine epidemiology, predisposing factors and microbiology of keratitis in north India

et al. 2020

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Background: Corneal opacification due to keratitis is a leading cause of blindness, with fungal pathogens being important causative agents. Thus, a prospective study was designed to identify the etiological agents; and assess the epidemiological features and risk factors for infective keratitis in India with particular reference to fungal keratitis.Methods: Corneal scrapings were collected from 151 patients and subjected to direct microscopic examination by gram’s stain, KOH wet mount, followed by fungal culture in sabouraud’s dextrose agar and bacterial culture in MacConkey’s agar and blood agar. Identification of fungal growth was done by colony morphology, slide culture and lacto phenol cotton blue wet mount preparation.Results: Out of the 151 cases of keratitis, 65 (43.0%) showed fungal elements on KOH smear. By culture methods, microbial etiology (fungal/ bacterial) was established in 68 (45.0%) patients. Aspergillus spp. (57.7%) was the most frequently isolated fungus, followed by Fusarium (15.4%), Penicillium (7.7%), Curvularia (9.6%), Alternaria (5.8%) and Candida albicans (1.9%). History of trauma with vegetative and non-vegetative material and prior ophthalmologic intervention were the major identifiable risk factors.Conclusions: Thus, aspergillus spp. is the most common cause for fungal keratitis in India, with A. fumigatus and A. flavus being the most familiar species, followed by Fusarium. Bacterial isolates were responsible for considerably fewer cases of keratitis.

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Section: Discussionsupporting

confidence: 88%

A prospective study to determine epidemiology, predisposing factors and microbiology of keratitis in north India

et al. 2020

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“…showed among bacteria's Staphylococcus was major gram-positive organism isolated followed by Streptococcus, which was the common pattern of growth seen all over India as well in our study. [11][12][13][14] In our study we found 47.7% of organism were gram positive cocci, study conducted by Gopinathan [15][16][17] In the present study majority of the Fungus isolated were like Aspergillus and Fusarium, it was observed that a study conducted by Lin CC et al showed prevalence of Aspergillus and Fusarium were common among southern region of India due to hot and windy climate. 18…”

Section: Discussionsupporting

confidence: 59%

Retrospective view on fungal and bacterial profile in the suspected cases of keratitis

Sumangala¹,

Sharlee²

2021

IJMR

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To study the microbial profile in the cases of keratitis. Materials and Methods: Retrospective cross-sectional study conducted during the period of January 2018 to January 2019. Corneal scrapping from suspected case of keratitis were subjected for microscopy and culture. Growth was examined for wet mount, colony morphology from culture tubes and plates, susceptibility of gram negative and gram-positive organism was done according to standard protocol (CLSI 2018). Result: In our study total of 239 samples, 17(7.1%) samples were only Microscopy positive, 69 (28.8%) samples were bacterial culture positive and 43 (17.9%) were fungal culture positive. Organisms isolated from bacterial culture were Staph, Pseudo, E. coli, Proteus, Enterobacter and Klebsiella species. Aspergillus, Fusarium, Microsporum, Curvalaria & Candida spp were isolated from fungal culture. No mixed growth was observed in our study. Conclusion:In our study we found about 28.8% of cases were positive for bacterial growth. Clinicians usually neglect bacterial cause of keratitis, so a good microbiological investigation play major role in management of corneal infection.

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“…Previous studies have indicated that the most frequently associated dematiaceous species were Curvularia spp., Alternaria spp., Exserohilum spp., and Cladosporium spp. [ 22 , 23 , 24 , 25 ]. Among these species, Curvularia spp.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand

Tangmonkongvoragul

Chokesuwattanaskul

Tananuvat

et al. 2021

JoF

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Dematiaceous fungal keratitis is an important etiology of visual loss, particularly in an agricultural society. From a retrospective review of medical records from 2012 to 2020, 50 keratitis cases of cultured-positive for dematiaceous fungi were presented at a tertiary care hospital in Northern Thailand. The study aimed to identify the isolated causative dematiaceous species using the PCR technique and to explore their related clinical features, including treatment prognoses. Sequencing of the amplified D1/D2 domains and/or ITS region were applied and sequenced. Of the 50 dematiaceous fungal keratitis cases, 41 patients were males (82%). In most cases, the onset happened during the monsoon season (June to September) (48%). The majority of the patients (72%) had a history of ocular trauma from an organic foreign body. The most common species identified were Lasiodiplodia spp. (19.35%), followed by Cladosporium spp. and Curvularia spp. (12.90% each). About half of the patients (52%) were in the medical failure group where surgical intervention was required. In summary, ocular trauma from an organic foreign body was the major risk factor of dematiaceous fungal keratitis in Northern Thailand. The brown pigmentation could be observed in only 26%. Significant prognostic factors for medical failure were visual acuity at presentation, area of infiltrate, depth of the lesions, and hypopyon.

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Epidemiological profile of mycotic keratitis in a tertiary care center of eastern Odisha

Cited by 13 publications

References 0 publications

A prospective study to determine epidemiology, predisposing factors and microbiology of keratitis in north India

A prospective study to determine epidemiology, predisposing factors and microbiology of keratitis in north India

Retrospective view on fungal and bacterial profile in the suspected cases of keratitis

The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand

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