Epidemiological features of Turkish patients with sarcoidosis

Müsellim, Benan; Kumbasar, Özlem Özdemir; Öngen, Gül; Çetınkaya, Erdoğan; Türker, Hatice; Uzaslan, Esra; Yentürk, Esin; Uzun, Oğuz; Sağlam, Leyla; Çelik, Gökhan; Okumuş, Gülfer; Annakkaya, Ali Nihat; Altıay, Gündeniz; Tabak, Levent; Şakar, Ayşın; Kıter, Göksel; Erturan, Serdar; Türktaş, Haluk; Yalnız, Enver; Akkoçlu, Atila; Öğüş, Candan; Doǧan, Ömer Tamer; Özkan, Metin; Aktoğu, Serir; Uzel, Işıl

doi:10.1016/j.rmed.2008.12.011

Cited by 49 publications

(46 citation statements)

References 42 publications

(31 reference statements)

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“…Previous studies have shown a protective or "beneficial" effect of smoking on the development and/or severity of different inflammatory and granulomatous diseases such as ulcerative colitis (10), Sjögren's syndrome (11) and sarcoidosis (24,25).…”

Section: Discussionmentioning

confidence: 99%

Association of cigarette smoking with organ damage in primary systemic vasculitis

Mohammad

Segelmark

2010

Scandinavian Journal of Rheumatology

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This is an author produced version of a paper published in Scandinavian Journal of Rheumatology.This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Methods. The pattern and extent of organ damage according to the Vasculitis DamageIndex (VDI) was analyzed for 86 prevalent cases with PSV retrieved from a geographically defined population in southern Sweden (WG: 46, MPA: 27, CSS: 4 and PAN: 9). Data on clinical findings, laboratory results and smoking habits were collected from case records from the time of diagnosis. The patients were stratified into two main groups according to their smoking habits: smokers (subdivided into active and ex-smokers) and non-smokers (patients who had never smoked).Results. Data on smoking habits were available for 77 patients (90%). Thirty-three (38%) patients were categorized as smokers and 44 (51%) were non-smokers. Smoking was more common in men (61.5% vs. 23.6% in women, p=0.001). There were no differences in smoking habits between the main diagnostic groups (WG 40% smokers, MPA 45%). Ear, nose, and throat (ENT) damage was significantly more prevalent in non-smokers (p=0.001).Myocardial infarction and end-stage renal disease (ESRD) were more common in the current smokers (p=0.04) than in the non-smokers. Conclusions.We found ENT damage to be significantly less prevalent in smokers. This is the first report on a possible modifying effect of cigarette smoking on the development of organ damage in PSV, but more studies are needed before any firm conclusions can be made.

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Section: Discussionmentioning

confidence: 99%

Association of cigarette smoking with organ damage in primary systemic vasculitis

Mohammad

Segelmark

2010

Scandinavian Journal of Rheumatology

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“…It has a worldwide distribution with regional variations in frequency because of differences in environmental exposure, genetic factors and surveillance methods (Bell 1991). A 2-year study, completed in 2007, was performed by the Clinical Issues Study Group of the Turkish Thoracic Society, finding that the annual incidence of sarcoidosis in Turkey was 4 in 100,000 (Musellim et al 2009). Sarcoidal granulomas may occur in any organ, and in more than 90 % of the patients, they occur in the lungs, intrathoracic lymph nodes, eyes, and skin.…”

Section: Introductionmentioning

confidence: 99%

Association between I/D polymorphism in the ACE gene and sarcoidosis in Turkish patients

Sarı¹,

Kurt

Saydam

et al. 2014

Cytotechnology

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Sarcoidosis is a chronic inflammatory disease with a complex pathogenesis and unknown etiology characterized by noncaseating granulomas that invade the lungs, eyes, liver and other organs. Insertion (I)/deletion (D) polymorphism in the gene encoding the angiotensin-converting enzyme (ACE) has been studied to examine the genetic predisposition to sarcoidosis in different populations, but the results have been inconsistent and inconclusive. This study aimed to determine the frequencies of the genotypes and alleles of I/D polymorphism in the ACE gene in Turkish patients as a distinct ethnic group and to investigate whether such polymorphism is associated with predisposition to sarcoidosis. Genomic DNA samples obtained from 154 individuals (70 patients with sarcoidosis and 84 healthy controls) were used in the study. The DNA was amplified using polymerase chain reactions using allele-specific primers. The amplified products were analyzed by 2 % agarose gel electrophoresis followed by UV transillumination. The allele frequencies and genotype distribution of the groups were analyzed using the Chi square test. There were no significant differences between the controls and sarcoidosis cases with respect to genotype distribution (v 2 = 4.202, p = 0.122) and allele frequencies (v 2 = 1.358, p = 0.244). Our results suggest that I/D polymorphism in the ACE gene does not cause a genetic predisposition to sarcoidosis in Turkish patients.

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“…13,17,[22][23][24][25][26] Biz bu çalışmada, hastaların TBB tanısallığını %78,3 gibi yüksek bir oranda saptamış olup, tetkikler içe-risinde tanısallığı en yüksek olarak bulduk. Bronkoskopik tetkikler içerisinde TBB komplikasyon riski göreceli olarak daha yüksek bir yöntem olarak görülmekle birlikte, pnömotoraks yaklaşık %5-7, majör kanama ise yaklaşık %1'in altında meydana gelmektedir.…”

Section: Bulgularunclassified

The Relationship Between Diagnostic Efficiency of Bronchoscopy with Clinical and Radiological Findings in Pulmonary Sarcoidosis

Öcal¹,

Bilgiç²,

Tozkoparan³

et al. 2015

Turkiye Klinikleri Arch Lung

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Ö ÖZ ZE ET T A Am ma aç ç: : Sarkoidozun kesin tanısı için histopatolojik incelemede kazeifikasyon göstermeyen epiteloid hücreli granülom yapısının gösterilmesi gereklidir. Bu açıdan; akciğer sarkoidozu kuşkusu olan tüm olgularda bronkoskopi endikasyonu mevcuttur. Seçilecek olan bronkoskopik tekniğin, olgunun klinik ve radyolojik özellikleri ile birlikte değerlendirilmesi önemlidir. Bu çalışmada, olguların radyolojik yaygın-lığı ve ağırlığı, klinik ağırlığı, laboratuvar tetkik sonuçları ile bronkoskopik tetkiklerin tanısal verimlilikleri arasında olası bir ilişkinin ortaya konması hedeflenmiştir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Değerlendirmeye alınan 103 hastanın PA akciğer grafisi, Toraks bilgisayarlı tomografi/yüksek rezolüsyonlu bilgisayarlı tomografileri, spirometri, DLCO, arteriyel kan gazı tahlilleri, biyokimyasal tetkikleri, kötü prognoz kriteri varlığı, bronkoskopik işlemdeki biyopsi tekniği ve sonuçları retrospektif olarak incelenmiştir. B Bu ul lg gu ul la ar r: : Bronkoskopi tanısal verimliliği %91,8 gibi yüksek bir değerde bulunmuştur. Mukoza biyopsisi, transbronşiyal biyopsi ve transbronşiyal iğne aspirasyonunun tek başlarına tanıya katkıları sırasıyla %12,2, %34,4 ve %8,8 olarak bulunmuştur. Transbronşiyal biyopsi tanısal verimliliği Evre 1 hastalarda Evre 2 hastalardaki kadar yüksek olup, tüm evrelerde en yüksek tanısal verimliliğe sahip yöntem olarak izlenmiştir. Radyolojik yaygınlık ile transbronşiyal biyopsi tanısallığı arasında anlamlı bir ilişki bulunmamış-tır. Mukozal lezyonu olan hastalardaki mukoza biyopsisi tanısal verimliliği anlamlı derecede yüksek izlenmiştir (p<0,05). Mukozal lezyon mevcudiyeti ve mukoza biyopsisi tanısallığının, klinik ve total radyolojik ağırlık ile aralarında anlamlı ilişki saptanmamakla birlikte, fissür çevresinde yer alan mikronodüller, mukoza biyopsisi pozitif olan grupta anlamlı derecede yüksek izlenmiştir (p<0,01). S So on nu uç ç: : Her bir tanısal bronkoskopik tetkikin tanıya tek başına katkısının mevcut olduğu göz önünde bulundurularak uygun hastalarda mümkün olduğunca her üç tetkiki de uygulamanın tanısal verimliliği artıracağı söyle-nebilir. Bu konuda daha geniş, çok-merkezli, prospektif çalışmalar ile sonuçlar geliştirilebilir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Biyopsi; bronkoskopi; sarkoidoz A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Diagnosis of sarcoidosis can be made by histopathological confirmation of granulomas without caseification necrosis. Bronchoscopy is indicated in patients with pulmonary sarcoidosis suspicion. In this study, we aimed to identify if there is a relationship between clinical and laboratory findings, radiological extent and weight with diagnostic efficacy of bronchoscopy in pulmonary sarcoidosis. M Ma at te e--r ri ia al l a an nd d M Me et th ho od ds s: : Chest X-ray and thorax computed tomography/high-resolution computed tomography findings, spirometry, DLCO, arterial blood gas, biochemical test results, presence of poor prognosis criteria, bronchoscopic technique res...

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Epidemiological features of Turkish patients with sarcoidosis

Cited by 49 publications

References 42 publications

Association of cigarette smoking with organ damage in primary systemic vasculitis

Association of cigarette smoking with organ damage in primary systemic vasculitis

Association between I/D polymorphism in the ACE gene and sarcoidosis in Turkish patients

The Relationship Between Diagnostic Efficiency of Bronchoscopy with Clinical and Radiological Findings in Pulmonary Sarcoidosis

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